Biophysical Society 66th Annual Meeting Program Guide

Platform Ion Channel Regulation and Assembly 8:15 am - 10:15 am, South, Level Two, Room 215/216 Co-Chairs Cathy Proenza, University of Colorado Denver, USA Huong T. Kratochvil, University of California, San Francisco, USA 2116-Plat 8:15 am BIOPHYSICAL PROPERTIES OF A NOVEL MITOCHONDRIAL LARGE UBIQUI- TOUS NON-SELECTIVE AMILORIDE SENSITIVE-LUNA-CURRENT. Enrique Balderas-Angeles , Sandra Lee, Thirupura Shankar, Anthony Balynas, Xue Yin, Dipayan Chaudhuri 2117-Plat 8:30 am STRUCTURAL AND FUNCTIONAL INVESTIGATIONS OF CLCA PROTEINS AS POTENTIATORS OF TMEM16 FAMILY MEMBERS. Monica Sala-Rabanal, Kayla N. Berry, Colin G. Nichols, Thomas J. Brett 2118-Plat 8:45 am DIFFERENTIAL REGULATION OF I KS BY TARGETED RECRUITMENT OF PROTEIN KINASE A TO DISTINCT SITES ON THE KCNQ1/KCNE1 CHANNEL COMPLEX. Xinle Zou, Sri Karthika Shanmugam , Scott A. Kanner, Kevin J. Sampson, Robert S. Kass, Henry M. Colecraft 2119-Plat 9:00 am INTERACTIONS OF HCN4 WITH LRMP AND IRAG. Cathy Proenza , Colin H. Peters, Danielle Jeffrey, John Bankston 2120-Plat 9:15 am ANIONIC LIPIDS UNLOCK THE GATE OF PACEMAKER CHANNELS. Philipp Schmidpeter , Di Wu, Jan Rheinberger, Paul M. Riegelhaupt, Haiping Tang, Carol V. Robinson, Crina M. Nimigean 2121-Plat 9:30 am FXYD6 DIMERIZATION IN HEART FAILURE. John Q. Yap , Jaroslava Seflova, Carson S. Miller, Seth L. Robia 2122-Plat 9:45 am THE DELICATE BALANCE BETWEEN APOLAR PACKING AND HYDROGEN BONDING DETERMINES MEMBRANE PROTEIN ASSEMBLY AND FUNC- TION. Huong T. Kratochvil , William DeGrado 2123-Plat 10:00 am SODIUM BINDING IS NOT REQUIRED FOR FLUORIDE CHANNEL FLUC DIMERIZATION BUT STABILIZES THE ACTIVE STATE. Melanie Ernst , Randy Stockbridge, Janice L. Robertson Poster Presentations and Late Posters 10:30 am - 12:30 pm, Exhibit Hall ABC Symposium Membrane Transporters 1:00 pm - 3:00 pm, South, Level Three, Room 301/302 Chair Da-Neng Wang, New York University, USA 2124-Symp 1:00 pm ASYMMETRIC INTERMEDIATES IN THE TRANSPORT CYCLE OF ABC TRANS- PORTERS. Hassane Mchaourab , Tarjani Thaker, Thomas Tomasiak, Smriti Mishra, Jose Faraldo-Gomez 2125-Symp 1:30 pm MECHANICS OF NRAMP-FAMILY TRANSITION METAL TRANSPORTERS. Rachelle Gaudet No Abstract 2:00 pm LINKING FUNCTION TO LOCAL AND GLOBAL DYNAMICS IN GLUTAMATE TRANSPORTERS. Olga Boudker

2105-Plat Travel Award Winner 2-DEOXY-ATP IMPROVES VENTRICULAR FUNCTION VIA COMBINED EF- FECTS ON MYOSIN RECRUITMENT FROM THE SUPER-RELAXED STATE, CROSSBRIDGE CYCLING AND CALCIUM DYNAMICS IN HEALTHY AND FAIL- ING CONDITIONS. Abigail E. Teitgen , Kimberly J. McCabe, Marcus Hock, Daniel A. Beard, Michael Regnier, Andrew D. McCulloch 2106-Plat 9:45 am CONTRACTION AND ELECTROPHYSIOLOGICAL ABNORMALITIES IN MYO- FILAMENT MUTATION-POSITIVE AND MUTATION-NEGATIVE HUMAN HCM MYOCARDIUM. J. Manuel Pioner , Giulia Vitale, Lorenzo Santini, Chiara Palandri, Alfonso Bueno-Orovio, Francesca Margara, Nicoletta Piroddi, Beatrice Scellini, Chiara Tesi, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi 2107-Plat 10:00 am ALLOSTERIC MODULATORS OF FORCE PRODUCTION : TOWARDS PRECI- SION MEDICINE FOR DIFFERENT CLASSES OF HEART DISEASES. Anne Houdusse , Julien Robert-Paganin, Daniel Auguin, Carlos Kikuti Platform Mechanosensation 8:15 am - 10:15 am, South, Level Two, Room 212/213/214 Co-Chairs Boris Martinac, Victor Chang Cardiac Research Institute, Australia Angela Ballesteros Morcillo, NIH, USA 2108-Plat 8:15 am PROBING PIEZO1 DIFFUSION HETEROGENEITY VIA SINGLE PARTICLE TRACKING AND MACHINE LEARNING. Alan T. Ly , Vivek Tyagi, Gabriella A. Bertaccini, Elizabeth L. Evans, J. Alfredo Freites, Douglas J. Tobias, Medha 8:30 am CYCLODEXTRINS INCREASE MEMBRANE TENSION AND ARE UNIVERSAL ACTIVATORS OF MECHANOSENSITIVE CHANNELS. Charles D. Cox , Yixiao Zhang, Boris Martinac, Thomas Walz 2110-Plat 8:45 am THE FUNCTIONAL ROLE OF CONNECTORS IN OUTER-HAIR-CELL HAIR BUNDLES. Zenghao Zhu , Anthony J. Ricci, Daibhid O Maoileidigh 2111-Plat 9:00 am MAGNETO-MECHANICAL MANIPULATION OF FULL-LENGHT HUMAN TAU40 IN LIVE-CELL NEURON CULTURES. Mackenna K. Landis , Anja Kunze 2112-Plat 9:15 am NUCLEAR ENVELOPE TENSION IMPACTS ON NUCLEAR VOLUME. Paolo Maiuri , Fabrizio Andrea Pennacchio, Alessandro Poli, Francesca M. Pramot- ton, Aldo Ferrari, Stefania Lavore, Ilaria Rancati, Marco Cosentino-Lago - marsino, Orso Maria Romano 2113-Plat 9:30 am PROBING THE BIOPHYSICAL MECHANISMS UNDERLYING AGING-ASSOCI- ATED DECLINE IN VASCULAR CELL MECHANOSENSATION USING A NOVEL ULTRASOUND-TWEEZERS SYSTEM. Apratim Bajpai , Ngoc Luu, Weiyi Qian, Rui Li, Weiqiang Chen 2114-Plat 9:45 am VDAC1: A STRUCTURAL INTERFACE BETWEEN PRIMARY CILIA AND METABOLISM ? Amandine Rovini , Yingbo Guo, Lucilla Fabbri, Monique Meyenberg Cunha-De Padua, Frederic Bost, Nathalie M. Mazure 2115-Plat 10:00 am REGULATION OF MEMBRANE HOMEOSTASIS BY TMC1 MECHANOELEC- TRICAL TRANSDUCTION CHANNELS IS ESSENTIAL FOR HEARING. Angela Ballesteros Morcillo 9:30 am M. Pathak 2109-Plat

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