Biophysical Society 66th Annual Meeting Program Guide

2126-Symp 2:30 pm STRUCTURAL CHARACTERIZATION OF THE REACTION CYCLE OF BACTE- RIAL DASS DICARBOXYLATE TRANSPORTERS. Da-Neng Wang , Ruben L. Gonzalez, Joseph A. Mindell, Christopher Mulligan, Emad Tajkhorshid Symposium The Dynamic Nature of Viruses 1:00 pm - 3:00 pm, South, Level Three, Room 303/304 Chair Ganesh Anand, Pennsylvania State University, USA 2127-Symp 1:00 pm CONFORMATIONAL DYNAMICS OF NUCLEAR PORE COMPLEXES. Martin Beck 2128-Symp 1:30 pm ENTER THE GOLIATHS: INFECTION BY GIANT VIRUSES. Kristin Parent , Jason R. Schrad, Anastasiya A. Lavell, Juliana R. Cortines, Jonatas Abrahao 2129-Symp 2:00 pm MACHINES FOR VIRAL GENOME DELIVERY. Nicholas Swanson, Fenglin Li, Ravi Lokareddy, Chun-Feng D. Hou, Gino Cingolani 2130-Symp 2:30 pm VIRUS BREATHING, METASTABILITY AND EPITOPE DYNAMICS. Ganesh S. Anand Platform Enzyme Function, Cofactors, and Post-translational Modifications 1:00 pm - 3:00 pm, South, Level Two, Room 201/202/203 Co-Chairs Jon McCord, Texas Tech University Health Sciences Center, USA Satarupa Bhaduri, University of California San Diego, USA 2131-Plat 1:00 pm A TWO-DIRECTIONAL VIBRATIONAL PROBE REVEALS THE DISTINCT ELECTRIC FIELD ORIENTATION AT THE ACTIVE SITE OF LIVER ALCOHOL DEHYDROGENASE. Chu Zheng , Yuezhi Mao, Jacek A. Kozuch, Austin O. Atsango, Zhe Ji, Thomas E. Markland, Steven G. Boxer 2132-Plat 1:15 pm PROTEIN ELECTRIC FIELDS REGULATE COVALENT INHIBITION OF BETA- LACTAMASES. Zhe Ji , Steven G. Boxer 2133-Plat 1:30 pm ENSEMBLE-FUNCTION RELATIONSHIPS TO CONNECT STRUCTURE TO MECHANISM: APPLICATION OF ENSEMBLEPDB TO THE SERINE PROTEASE REACTION COORDINATE AND ITS CATALYTIC FEATURES. Siyuan Du , Ra- chael C. Kretsch, Jacob Parres-Gold, Daniel A. Peñaherrera, Filip Yabukar- ski, Margaux M. Pinney, Dan Herschlag 2134-Plat 1:45 pm AN IN VITRO PLATFORM ENABLES CATALYTIC CHARACTERIZATION OF AN INTRAMEMBRANE RHOMBOID PROTEASEAN IN-VITRO PLATFORM ENABLES CATALYTIC CHARACTERIZATION OF AN INTRAMEMBRANE RHOMBOID PROTEASE. Satarupa Bhaduri , Anahita Nejatfard, Lawrence Liu, Gentry Patrick, Kvido Strisovsky, Anthony O'Donoghue, Sonya E. Neal 2135-Plat 2:00 pm STRUCTURAL FEATURES OF DNASE1L3 RESPONSIBLE FOR DIVERSE ANTI- GENIC SERUM DNA CLEARANCE. Jon J. McCord , Minal Engavale, Elahe Masoumzadeh, Johanna Villarreal, Britney Mapp, Michael Latham, Peter Keyel, Roger B. Sutton

2136-Plat 2:15 pm METFORMIN SUPPRESSES HEPATIC GLUCONEOGENESIS VIA H3R17 DIMETHYLATION BY INHIBITING CARM1. Sinjini Dhang 2137-Plat 2:30 pm UNDERLYING MECHANISM FOR LOWER GMP FORMATION IN HGBP2 AND ROLE OF ITS INDIVIDUAL DOMAINS IN GTP HYDROLYSIS. Monika Mittal , Sudeepa Rajan, Apurba K. Sau 2138-Plat 2:45 pm IMPROVEMENT OF THE ACTIVITY AND THERMOSTABILITY OF THE L-GLU- TAMATEOXIDASE BY DIRECTED EVOLUTION AND STRUCTURE ANALYSIS. Yiying Lin , Yujie Zhang, Fang Wang, Huiyong Lian, Qingdai Liu Platform Protein Aggregates 1:00 pm - 3:00 pm, South, Level Two, Room 204/205/206 Co-Chairs Matthias Wilmanns, EMBL Hamburg, Germany VANESA Ramirez Bello, Universidad Autónoma del Estado de Morelos - UAEM, Mexico 2139-Plat 1:00 pm MECHANISM OF SECONDARY NUCLEATION FROM THE DIRECT OBSERVA- TION OF AB42 AGGREGATION AT THE SINGLE FIBRIL LEVEL. Manuela R. Zimmermann , Subhas C. Bera, Georg Meisl, Sourav Dasadhikari, Shamas- ree Ghosh, Sara Linse, Kanchan Garai, Tuomas P.J. Knowles 2140-Plat 1:15 pm FLUORESCENCE CORRELATION SPECTROSCOPY AS A TOOL TO DISTIN- GUISH SOLUBLE P53 AGGREGATES. Matthew Steinsaltz , Zachary Levine 2141-Plat 1:30 pm IS TOXIC AMYLOID FORMATION TRIGGERED BY PROTEIN LIPIDATION. John M. Sanderson 2142-Plat 1:45 pm MECHANISM OF POLYMERIZATION-INDUCED DEACTIVATION OF THE ONCOGENE CTBP BY THE ONCOGENE SUPPRESSOR RAI2. Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Klaus Pantel, Matthias Wilmanns 2143-Plat 2:00 pm COARSE-GRAINED MOLECULAR DYNAMICS STUDY OF FIBRIL FORMATION OCCURRING IN THE LOW COMPLEXITY DOMAIN OF FUSED IN SARCOMA WITHIN A LIQUID DROPLET ENVIRONMENT. Thomas P. Dannenhoffer- Lafage , Robert B. Best 2144-Plat 2:15 pm SPECTROSCOPIC TECHNIQUES TO EVALUATE THE UNFOLDING AND AGGREGATION OF THE HΒB2 CRYSTALLIN DUE TO THE EFFECT OF UV-B RADIATION. IMPLICATIONS FOR CATARACT FORMATION. Vanesa Ramirez Bello , Carlos Amero-Tello 2145-Plat 2:30 pm ASPERGILLUS FUMIGATUS HYDROPHOBIN FUNCTIONAL AMYLOIDS. Borja Rodriguez de Francisco, Isabel Valsecchi, Ariane Pillé, Chi L. Pham, Vincent Duprès, Frank Lafont, Jagadesh Bayry, Vishukumar Aimanianda, Margaret Sunde, Inaki Guijarro 2146-Plat 2:45 pm Travel Award Winner SHIKONIN INHIBITS TAU AGGREGATION AND PHASE SEPARATION AND IMPROVES THE VIABILITY OF SH-SY5Y CELLS AFTER EXPOSURE TO TAU OLIGOMERS. Anuradha Venkatramani , Sandipan Mukherjee, Anuradha Kumari, Dulal Panda

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