Biophysical Society 66th Annual Meeting Program Guide

Platform Computational Methods and Bioinformatics II 1:00 pm - 3:00 pm, South, Level Two, Room 207/208 Co-Chairs Mitsugu Araki, Kyoto University, Japan Yaojun Zhang, Princeton University, USA 2147-Plat 1:00 pm NOVEL DEEP LEARNING ENERGY-BASED MODEL TO PREDICT PROTEIN DYNAMICS. Hyun Park , Emad Tajkhorshid 2148-Plat 1:15 pm SIMULATING FREELY-DIFFUSING SINGLE-MOLECULE FRET DATA WITH CONSIDERATION OF PROTEIN CONFORMATIONAL DYNAMICS. James Losey , Michael Jauch, Axel Cortes-Cubero, Haoxuan Wu, Roberto Rivera, David S. Matteson, Mahmoud Moradi 2149-Plat 1:30 pm UNCERTAINTY IN MARKOV STATE MODELS FOR SMALL MACROMOL - ECULES. Nicolai Kozlowski , Helmut Grubmuller 2150-Plat 1:45 pm RESOLVING LARGE CONFORMATIONAL CHANGE PATHWAYS THROUGH MACHINE LEARNING AND ENHANCED SAMPLING SIMULATIONS. Yui Tik Pang , James C. Gumbart 2151-Plat 2:00 pm A MARKOV MODEL FOR ROTARY CATALYSIS OF F 1 -ATPASE. Yixin Chen 2152-Plat 2:15 pm A MULTISCALE MOLECULAR SIMULATION APPROACH FOR ASSESSING THE EFFECTS OF MUTATIONS ON FUNCTIONAL ACTIVITY AND DRUG SENSITIVITY IN KINASES. Mitsugu Araki , Yasushi Okuno 2153-Plat 2:30 pm SEARCHING FOR SEQUENCE FEATURES THAT CONTROL DNA FLEXIBILITY. Yaojun Zhang , Aakash Basu, Taekjip Ha, William Bialek 2154-Plat 2:45 pm DECODING GENE NETWORK MODELS AND RATES FROM SMFISH DATA. Camille Moyer, Zeliha Kilic, Douglas P. Shepherd, Steve Pressé Platform DNA Replication, Recombination, and Repair 1:00 pm - 3:00 pm, South, Level Two, Room 209/210/211 Co-Chairs Monika Makurath, University of Illinois at Urbana-Champaign, USA Jaigeeth Deveryshetty, Saint Louis University, USA 2155-Plat 1:00 pm REGULATION OF REP HELICASE UNWINDING BY PRIC AND SSB. Monika A. Makurath , Binh Nguyen, Timothy M. Lohman, Yann R. Chemla 2156-Plat 1:15 pm RECA FINDS HOMOLOGOUS DNA BY REDUCED DIMENSIONALITY SEARCH. Jakub Wiktor 2157-Plat 1:30 pm Travel Award Winner MYCOBACTERIUM TUBERCULOSIS DNA-REPAIR HELICASE UVRD1 IS ACTIVATED BY REDOX-DEPENDENT DIMERIZATION VIA A CONSERVED 2B DOMAIN CYSTEINE. Ankita Chadda , Drake Jensen, Eric J. Tomko, Ana Ruiz Manzano, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt 2158-Plat 1:45 pm ALLOSTERY OF RAD52 DURING PRE-SYNAPSIS COMPLEX ASSEMBLY IN HOMOLOGOUS RECOMBINATION MEDIATED REPAIR. Jaigeeth Deveryshetty , Michael Rau, James A.J. Fitzpatrick, Edwin Antony

2159-Plat 2:00 pm A DNA REPAIR PATHWAY CAN REGULATE TRANSCRIPTIONAL NOISE TO PROMOTE CELL FATE TRANSITIONS. Leor S. Weinberger 2160-Plat 2:15 pm Travel Award Winner INVESTIGATING THE ROLE OF LOCAL DNA CONFORMATIONAL DYNAM - ICS IN PROCESSIVE DNA POLYMERASE HOLOENZYME-PRIMER-TEMPLATE DNA COMPLEX FORMATION. Patrick J. Herbert , Dylan Heussman, Jack W. Maurer, Steven E. Weitzel, Peter H. von Hippel, Andrew H. Marcus 2161-Plat 2:30 pm KINETICS OF TOPOLOGICAL TRANSITIONS IN DNA MEDIATED BY TOPOI - SOMERASES AND RECOMBINASES. Andreas Hanke , Ryan P. Compton, Riccardo Ziraldo, Stephen D. Levene 2162-Plat 2:45 pm MULTI-TARGET CRISPR FOR HIGH-THROUGHPUT STUDIES OF DOUBLE- STRAND BREAK REPAIR AND GENETIC BARCODING AT ENDOGENOUS SITES. Alberto Marin-Gonzalez , Roger S. Zou, Rachel Dveirin, Yang Liu, Leo Shen, Jay Luo, Reza Kalhor, Taekjip Ha Platform Cytoskeletal Mechanics and Dynamics 1:00 pm - 3:00 pm, South, Level Two, Room 212/213/214 Co-Chairs Marija Zanic, Vanderbilt University, USA Ondrej Kucera, CEA Grenoble Center, France 2163-Plat 1:00 pm HUNTINGTIN S421 PHOSPHORYLATION AND EXPRESSION LEVELS DIF - FERENTIALLY AFFECT SIGNALLING AND DEGRADATIVE INTRACELLULAR CARGOES. Emily N.P. Prowse , Abdullah R. Chaudhary, David Sharon, Adam G. Hendricks 2164-Plat 1:15 pm MICROTUBULE-BASED TRANSPORT IS ESSENTIAL TO DISTRIBUTE RNA AND NASCENT PROTEIN IN SKELETAL MUSCLE. Lance T. Denes , Chase P. Kelley, Eric Wang 2165-Plat 1:30 pm A SINGLE-MOLECULE APPROACH TO DECIPHER ASSEMBLY AND ENTRY OF TRAINS INTO C.ELEGANS SENSORY CILIA. Aniruddha Mitra , Erwin J. 1:45 pm SSNA1 STABILIZES DYNAMIC MICROTUBULES AND DETECTS MICRO - TUBULE DAMAGE. Elizabeth Lawrence, Goker Arpag, Cayetana Arnaiz, Marija Zanic 2167-Plat 2:00 pm CONNECTIONS DISTRIBUTED WITHIN 3 ΜM OF CHROMOSOMES ARE NECESSARY AND SUFFICIENT FOR THE KINETOCHORE-FIBER’S ROBUST ANCHORAGE IN THE MAMMALIAN SPINDLE. Pooja Suresh , Vahe Gal - styan, Rob Phillips, Sophie Dumont 2168-Plat 2:15 pm AUTOREGULATORY CONTROL OF THE STABILITY AND PLASTICITY OF CYTOSKELETAL NETWORKS. Ondrej Kucera , Jérémie Gaillard, Christophe Guérin, Manuel Théry, Laurent Blanchoin 2169-Plat 2:30 pm FORCEFUL RETRACTION OF ARM-LIKE APPENDAGES ALLOWS BACTERIA TO DISTINGUISH THEIR MECHANICAL ENVIRONMENT. Matthias D. Koch , Endao Han, Zemer Gitai, Joshua W. Shaevitz 2170-Plat 2:45 pm LONG-TERM HIGH-RESOLUTION LATTICE LIGHT SHEET IMAGING OF BACTERIAL COMMUNITIES IN PHYSIOLOGICALLY RELEVANT CONDITIONS. Eric D. Donarski, Yibo Wang, Ji Zhang, Jie Wang, Scott T. Acton, Andreas Gahlmann Peterman 2166-Plat

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