Biophysical Society 66th Annual Meeting Program Guide

2200-Pos Board B30 FREE ENERGY SURFACE CALCULATIONS FOR CONFORMATIONAL TRANSI - TIONS IN THE CARDIAC THIN FILAMENT USING METADYNAMICS. Allison B. Mason , Jil C. Tardiff, Steven D. Schwartz 2201-Pos Board B31 DYNAMICAL SHIFTS IN HYDROGEN BOND OCCUPANCIES IDENTIFY MECH - ANISMS RESPONSIBLE FOR RESISTANCE CONFERRING MUTATIONS. Ebru Cetin, Yusuf T. Tamer, Erdal Toprak, Ali Rana Atilgan, Canan Atilgan 2202-Pos Board B32 ENTROPY OF PROTEIN OSCILLATIONS WITH VARIATIONAL DAMP - ING. Hunter Baker , Garrett Baughman, Preet Sharma 2203-Pos Board B33 ALLOSTERIC PROTEIN SPECIFIC FORCE FIELD BASED ON DEEP LEARN - ING. Jun Chen, Xiaoyue Ji, Wen Xiao , Zhiyi Wu, Cheng Jiang, Jian Zhang, Zhengtian Yu, Hai-Feng Chen 2204-Pos Board B34 VIBRATIONAL DENSITY OF STATES CAPTURE THE ROLE OF DYNAMIC ALLOSTERY IN PROTEIN EVOLUTION. Tushar Modi , Matthias Heyden, S. Banu Ozkan 2205-Pos Board B35 PROTEIN DYNAMICS PROVIDE MECHANISTIC INSIGHTS ABOUT THE EPISTATIC RELATIONSHIPS AMONG HIGHLY OBSERVED POTENTIALLY ADAPTIVE MISSENSE VARIANTS. Nicholas J. Ose , Paul Campitelli, Ravi P. Patel, S. Banu Ozkan, Sudhir Kumar 2206-Pos Board B36 THE ROLE OF VIRAL GENOMIC RNA-PROTEIN INTERACTIONS IN ENVI - RONMENTAL SENSING, UNCOATING, AND RNA RELEASE. Sean M. Braet , Varun X. Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh S. Anand 2207-Pos Board B37 COMPARING STRUCTURAL ENSEMBLES WITH DIFFNETS HELPS EXPLAIN THE ACTIVATION MECHANISM OF THE SARS-COV-2 PROTEIN NSP16. Michael D. Ward 2208-Pos Board B38 UNRAVELING SARS-COV-2 SPIKE PROTEIN ACTIVATION PATHWAY REVEAL UNPRECEDENTED CRYPTIC POCKETS. HishamM. Dokainish , Suyong Re, Takaharu Mori, Chigusa Kobayashi, Jaewoon Jung, Yuji Sugita 2209-Pos Board B39 TRANSCRIPTIONAL FACTORS CONTROL THEIR DIFFUSION ON DNA BY MODULATING THEIR DYNAMICS. Rama Reddy Goluguri , Mourad Sadqi, Victor Munoz 2210-Pos Board B40 ACCELERATED CYCLIC PEPTIDE ENSEMBLE GENERATION USING RESER - VOIR REMD. Shawn C.C. Hsueh , Steven S. Plotkin 2211-Pos Board B41 HYDRATION-WATER AND MEMBRANE LIPIDS MODULATE G-PROTEIN- COUPLED RECEPTOR ACTIVATION. Nipuna Weerasinghe , Steven D.E. Fried, Andrey V. Struts, Suchithranga M.D.C. Perera, Michael F. Brown 2212-Pos Board B42 ACTIVATION OF G-PROTEIN-COUPLED RECEPTORS BY HYDRATION DRIVEN SPONGE MECHANISM. Steven D.E. Fried , Kushani S.K. Hewage, Anna R. Eitel, Andrey V. Struts, Nipuna Weerasinghe, Suchithranga M.D.C. Perera, Michael F. Brown 2213-Pos Board B43 KINETIC ENERGY FLOWS IN ACTIVATED DYNAMICS OF BIOMOL - ECULES. Huiyu Li

2214-Pos Board B44 STRUCTURAL DYNAMIC CHANGES IN THE SARS-COV AND SARS-COV-2 S SPIKE ASSEMBLIES UPON ACE2 ACTIVATION. Chengbo Chen , James B. Munro, Kelly K. Lee 2215-Pos Board B45 FRUSTRATION IN THE COUPLED FOLDING-BINDING PROCESS OF COLICIN E3 RRNASE WITH IMMUNITY PROTEIN IM3. Meng Gao, Zhengding Su, Yongqi Huang 2216-Pos Board B46 INVESTIGATION INTO THE EFFECT OF DIMERIZATION ON PKR ACTIVATION ENERGETICS AND DYNAMICS WITH ENHANCED SAMPLING MOLECULAR DYNAMICS. Aaron G. Feinstein , Eric R. May, James L. Cole 2217-Pos Board B47 CONFORMATIONAL DYNAMICS OF THE CLPB AAA+ PROTEIN DISAGGRE - GASE: MOLECULAR DYNAMICS STUDIES. Ashan Dayananda , Ruxandra I. Dima, George Stan 2218-Pos Board B48 UNCOVERING INTER- AND INTRA-RAFT DYNAMICS OF ICOSAHEDRAL FLAVIVIRUS ASSEMBLIES. Theresa S.C. Buckley , Ganesh S. Anand 2219-Pos Board B49 PLASTICIZATION OF PROTEIN DYNAMICS BY WATER, A MOLECULAR DY - NAMICS STUDY. Shiv S. Seshan , Jack Douglas, Esmael J. Haddadian 2220-Pos Board B50 HOST CELL MEMBRANE CAPTURE BY THE SARS-COV-2 SPIKE PROTEIN FU - SION INTERMEDIATE. Rui Su , Jin Zeng, Ben O'Shaughnessy 2221-Pos Board B51 THE ROLES OF GLYCANS IN THE SARS-COV-2 SPIKE PROTEIN. Lorenzo Casalino , Rommie E. Amaro 2222-Pos Board B52 ALLOSTERIC PATHWAYS OF PH-SENSITIVITY IN A PROTON ACTIVATED CHLORIDE CHANNEL. Ekaterina D. Kots , James Osei-Owusu, Zhaozhu Qiu, Harel Weinstein 2223-Pos Board B53 MULTI-CONTACT DESCRIPTION OF PROTEIN-PROTEIN INTERACTIONS. Yue Qiu , Wonmuk Hwang Membrane Protein Structures II (Boards B54 - B69) 2224-Pos Board B54 INVESTIGATION OF THE C-TERMINAL DOMAIN OF CAVEOLIN-1 THROUGH MOLECULAR DYNAMICS SIMULATIONS. Thomas V. Perone , Soohyung Park, Kerney Jebrell Glover, Wonpil Im 2225-Pos Board B55 IDENTIFY THE CONFORMATIONAL STATES OF GLYCINE RECEPTOR ALPHA3 THROUGH UMBRELLA SAMPLING. Xiongwu Wu , Bernard R. Brooks 2226-Pos Board B56 MYR-ARF1 CONFORMATIONAL FLEXIBILITY AT THE MEMBRANE SURFACE: INSIGHTS FOR ITS INTERACTIONS WITH ASAP1. Yue Zhang , Olivier Sou - bias, Shashank Pant, Frank Heinrich, Alexander Vogel, Jess Li, Daniel Hus - ter, Paul Randazzo, Mathias Losche, Emad Tajkhorshid, R. Andrew Byrd 2227-Pos Board B57 COMPARING THE DYNAMICS OF THE BAM COMPLEX BETWEEN TWO SPECIES. Zixing Fan , Zijian Zhang, Evan Billings, Nicholas Noinaj, James C. Gumbart

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