Biophysical Society 66th Annual Meeting Program Guide

2415-Pos Board B245 QUANTUM CALCULATIONS ON PROTON’S ROLE IN GATING THE KV1.2 CHANNEL; THE ROLE OF AN ARGININE/GLUTAMATE/TYROSINE TRIAD OF AMINO ACIDS. Alisher M. Kariev, Michael E. Green 2416-Pos Board B246 THE RECOVERY FROM THE C-TYPE INACTIVATED STATE DIFFERS BETWEEN SHAKER AND SHAKER-W434F K + CHANNELS. Laura Coonen , Evelyn Martinez-Morales, Luis G. Cuello, Dirk J. Snyders, Alain J. Labro 2417-Pos Board B247 MUTATIONS IN THE OUTER PORE AFFECTING C-TYPE INACTIVATION IN SHAKER AND KV1.2 CHANNELS. Xiaosa Wu , Kenton Swartz 2418-Pos Board B248 STRUCTURAL DETERMINANTS OF SHIFTED KV6.4 INACTIVATION KINET - ICS. Gabriel Lacroix , Alain J. Labro, Rikard Blunck 2419-Pos Board B249 SELECTIVITY FILTER DYNAMICS IN A POTASSIUM SELECTIVE AND NON- SELECTIVE CHANNELS. Marcos Matamoros , Xue Wen Ng, David W. Piston, Colin G. Nichols 2420-Pos Board B250 CONKUNITZIN-C2 FROM CONUS CONSORS INDUCES AN INCOMPLETE BLOCK OF THE SHAKER K + CHANNEL USING A UNIQUE MODE OF AC - TION. Chandamita Saikia , Hagit Altman-Gueta, Orly Dym, Izhar Karbat, Eitan Reuveny 2421-Pos Board B251 A MUTANT KCSA CHANNEL THAT CAUSES THE SAME RUBIDIUM AND POTASSIUM IONS OCCUPANCY WITHIN THE CHANNEL’S SELECTIVITY FILTER. Doris M. Cortes, Luis G. Cuello 2422-Pos Board B252 FREE ENERGY OF HYDROPHOBIC DEWETTING IN GATING OF BK CHAN - NELS. Erik B. Nordquist , ZhiGuang Jia, Jianhan Chen 2423-Pos Board B253 INTRINSIC OPENING OF BK CHANNELS DERIVES FROM THE LEAKAGE OF HYDROPHOBIC GATING. ZhiGuang Jia, Guohui Zhang, Jingyi Shi, Jianmin Cui, Jianhan Chen 2424-Pos Board B254 Travel Award Winner THE VRAC BLOCKER DCPIB DIRECTLY GATES BK CHANNELS AND IN - CREASES INTRACELLULAR CA 2+ IN MELANOMA AND PANCREATIC DUCT ADENOCARCINOMA CELL LINES. Paolo Zuccolini , Loretta Ferrera, Alessia Remigante, Cristiana Picco, Raffaella Barbieri, Sara Bertelli, Oscar Moran, Paola Gavazzo, Michael Pusch 2425-Pos Board B255 TISSUE-SPECIFIC REGULATION OF BK CHANNEL BETA1 AND BETA4 SUB - UNIT MEMBRANE FRACTIONS BY CHOLESTEROL. Steven C. Mysiewicz , Alexandria V. Slayden, Jerusalem Alleyne, Alex M. Dopico, Anna N. Bukiya 2426-Pos Board B256 CD 2+ INHIBITION OF BK CHANNELS AFTER DTT TREATMENT SEEMS NOT TO INVOLVE CYSTEINES. Guohui Zhang , Huanghe Yang, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Jonathan R. Silva, Jianmin Cui 2427-Pos Board B257 Travel Award Winner PROGESTERONE ACTIVATES BK CHANNELS BY BINDING TO TRANS - MEMBRANE AMINO ACIDS OF THE CHANNEL Β1 REGULATORY SUB - UNIT. Kelsey C. North , Anna N. Bukiya, Alex M. Dopico 2428-Pos Board B258 NOVEL CONCATENATED TANDEM CONSTRUCTS REVEAL 3 DISTINCT TYPES OF SUBUNIT STOICHIOMETRY IN BK CHANNEL MODULA - TION. Guanxing Chen , Qin Li, Jiusheng Yan

2429-Pos Board B259 K V 3.1 CHANNEL EXPRESSION DETERMINES THE SPIKE WAVEFORM IN VOCAL-MOTOR NEURONS. Benjamin Zemel , Alexander A. Nevue, Peter V. Lovell, Claudio V. Mello, Henrique von Gersdorff 2430-Pos Board B260 MANIPULATING SHAKER POTASSIUM CHANNEL GATING KINETICS WITH TEMPERATURE STEPS. Bernardo I. Pinto , Carlos Alberto Z. Bassetto Jr, Ramon Latorre, Francisco Bezanilla 2431-Pos Board B261 CA 2+ -DEPENDENT PHOTOCROSSLINKING IN THE BK CHANNEL INTRACEL - LULAR INTERSUBUNIT INTERFACES. Alberto Jesus Gonzalez Hernandez , Belinda Rivero-Perez, David Bartolome-Martin, Diego Alvarez de la Rosa, Andrew J.R. Plested, Teresa Giraldez 2432-Pos Board B262 PLASTICITY OF GATING IN PORE-ONLY POTASSIUM CHANNELS. Oliver Rauh , Indra Schroeder, Gerhard Thiel 2433-Pos Board B263 STRUCTURAL BASIS AND STOICHIOMETRY FOR THE GATING OF A SHAL - TYPE POTASSIUM CHANNEL. Wenlei Ye , Lily Y. Jan, Chia-Hsueh Lee Ion Channels, Pharmacology, and Disease II (Boards B264 - B278) 2434-Pos Board B264 IDENTIFICATION OF CARDIAC LIABILITY IN DRUG DISCOVERY USING AUTOMATED PATCH CLAMP: EXPERIMENTAL AND TECHNICAL CON - SIDERATIONS FOR HIGH THROUGHPUT RECORDINGS OF NAV1.5 AND HERG. Maria Giustina Rotordam, Alison Obergrussberger, Nina Brink - wirth, Kiyoshi Takasuna, Nadine Becker, András Horváth, Hatsue Furu - kawa, Yuka Hasegawa, Takayuki Oka, Niels Fertig , Sonja Stoelzle-Feix 2435-Pos Board B265 MODELING OF PEPTIDE TOXIN - ION CHANNEL INTERACTIONS USING ROSETTADOCK. Diego Lopez Mateos , Vladimir Yarov-Yarovoy 2436-Pos Board B266 FUNCTIONAL EVIDENCE OF A NOVEL MECHANISM OF ALLOSTERIC MODULATION OF THE VOLTAGE GATED SODIUM CHANNEL. Nolan M. Dvorak , Paul Wadsworth, Aditya K. Singh, Cynthia Tapia, Pingyuan Wang, Haiying Chen, Jia Zhou, Fernanda Laezza 2437-Pos Board B267 Travel Award Winner PATHOLOGICALLY INCREASED RYR2-NA V 1.6 COLOCALIZATION IN DB/DB MOUSE MODEL OF DIABETIC CARDIOMYOPATHY. AndrewM. Soltisz , Heather Struckman, Przemysław Radwanski, Rengasayee Veeraraghavan 2438-Pos Board B268 ARRHYTHMOGENIC CALMODULIN MUTANT D96V INDUCES UNEXPECT - ED REMODELING OF CARDIAC NANOSTRUCTURE. Heather L. Struck- man , Mikhail Tarasov, Yusuf Olgar, Alec Miller, Jonathan P. Davis, Sandor Gyorke, Rengasayee Veeraraghavan, Przemyslaw Radwanski 2439-Pos Board B269 DISCOVERY OF HUMAN HV1 CHANNEL PEPTIDE INHIBITORS. Ádám Fehér , Jes s Borrego, Samuel Cardoso-Arenas, Iván Arenas, Herlinda Clement, Gerardo Corzo, Gyorgy Panyi, Zoltan Varga, Ferenc Papp 2440-Pos Board B270 NEW CACNA1D MISSENSE VARIANTS CAUSING A NEURODEVELOpmEN - TAL DISORDER SHOW INCREASED DIHYDROPYRIDINE SENSITIVITY. Ferenc Török , Ludovica Filippini, Melissa Mairböck, Anna S. Ladstätter, Raphaela S. Drexel, Joerg Striessnig, Nadine J. Ortner

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