Biophysical Society 66th Annual Meeting Program Guide

Symposium Host-Pathogen Interactions 8:15 am - 10:15 am, South, Level Three, Room 303/304 Chair Sergei Sukharev, University of Maryland, USA 29-Symp 8:15 am ONE SMALL STEP TOWARD ALL-ATOMMODELING AND SIMULATION OF THE MYCOBACTERIA CELL ENVELOPE. Wonpil Im 30-Symp 8:45 am A LOOK AT MEMBRANE CURVATURE AND REMODELING WITH SUAVE - SURFACE ASSESSMENT VIA GRID EVALUATION. Denys Santos, Kaline Coutinho, Thereza A. Soares 31-Symp 9:15 am THE BEST DEFENSE IS A CHEAP OFFENSE? HOW GRAM-NEGATIVE BACTE- RIA BUILD THEIR OUTER MEMBRANES AND SECRETE TOXINS WITHOUT TYPICAL SOURCES OF ENERGY. James Gumbart 32-Symp 9:45 am TEASING HALF-BILAYERS: LPS VERSUS PHOSPHOLIPID MONOLAYERS, MECHANICS, ASYMMETRY AND IMPLICATIONS FOR DRUG PERMEATION. Sergei Sukharev , Hannah Cetuk, Jake Rosetto, Joseph Najem, Alison J. Scott, Myriam L. Cotten, Robert K. Ernst Platform Protein-Small Molecule Interactions 8:15 am - 10:15 am, South, Level Two, Room 201/202/203 Co-Chairs THE RETINAL BINDING PROTEIN FAMILY: A POWERFUL TEMPLATE FOR DESIGN AND DISCOVERY. Jim H. Geiger , Alireza Ghanbarpout, Courtney Bingham, Nona Ehyaei, Rahela Estmatpoursalmani, SohamMaity 34-Plat 8:30 am MEASUREMENT OF PROTAC TERNARY COMPLEX FORMATION USING THE SWITCHSENSE® Y-STRUCTURE AND FRET SIGNALS. Aishwarya Mahadevan , Alice Soldá, Irene Ponzo, Thomas Weber, Jonathan Faherty 35-Plat 8:45 am DEVELOPING DRUGS AGAINST ESSENTIAL PROTEINS OF SARS-COV-2 FOR THE TREATMENT OF COVID-19. Teena Bajaj 36-Plat 9:00 am USING NOVEL SMALL MOLECULES TO ALTER CARDIAC THIN FILAMENT FUNCTION. SaiLavanyaa Sundar , Anita Ghosh, Sheema J. Bojan, Michael J. Rynkiewicz, Lauren E. Brown, William Lehman, Jeffrey R. Moore, Elumalai Pavadai 37-Plat 9:15 am ABSOLUTE BINDING FREE ENERGY CALCULATIONS FOR SMALL MOLE- CULES BINDING AT THE MEMBRANE PROTEIN - LIPID BILAYER INTERFACE. Charlie Cook , Ewa Chudyk, Ronald Knegtel, Philip C. Biggin 38-Plat 9:30 am UNVEILING THE REACTION MECHANISM OF BRUTON’S TYROSINE KINASE INHIBITION BY IBRUTINIB. Angela M. Barragan , Benoit Roux 39-Plat 9:45 am LIGAND DISCOVERY FOR LAT1 WITH MOLECULAR DYNAMICS SIMULA- TION AND VIRTUAL SCREENING. Keino K. Hutchinson , Dina Buitrago Silva, Huy Ngo, Avner Schlessinger, Kathleen Giacomini, Allen Thomas Jim Geiger, Michigan State University, USA Angela Barragan, University of Chicago, USA 33-Plat 8:15 am

Sunday, February 20

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Biophysical Journal Editorial Board Boot Camp 7:00 am - 9:00 am, South, Level Three, Room 313/314 Postdoctoral Breakfast 7:30 am - 8:30 am, Esplanade, Room 156 Support contributed by the Burroughs Wellcome Fund. This breakfast presents an opportunity for postdoctoral Annual Meeting attendees to meet and discuss the issues they face in their current career stage. Limited to the first 100 attendees. Hosts Anthony Cammarato, Johns Hopkins University, USA Registration/Exhibitor Registration 7:30 am - 5:00 pm, South Lobby Poster Viewing 8:00 am - 10:00 pm, Exhibit Hall ABC Symposium Nuclear Condensates 8:15 am - 10:15 am, South, Level Three, Room 301/302 Chair Geeta Narlikar, University of California, San Francisco, USA 26-Symp 8:15 am A MODEL FOR CHROMATIN ORGANIZATION THROUGH LIQUID-LIQUID PHASE SEPARATION. Michael K. Rosen No Abstract 8:45 am ENHANCER CROSSTALK: DO TRANSCRIPTIONAL HUBS SHAPE EVOLU- TION? Justin Crocker 27-Symp 9:15 am NEW INSIGHTS INTO FORMATION, ORGANIZATION AND FUNCTION OF HETEROCHROMATIN CONDENSATES. Serafin Colmenares, Srivarsha Rajshekar, Lucy D. Brennan, Collin Hickmann, Nicolas Altemose, Gary H. Karpen 28-Symp 9:45 am A HEXASOME IS THE PREFERRED SUBSTRATE OF THE INO80 CHROMATIN REMODELING COMPLEX. Geeta Narlikar , Laura Hsieh, Muryam Gourdet, Vijay Ramani Harpreet Singh, The Ohio State University, USA Christian Jorgensen, John Hopkins University, USA

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