Biophysical Society 66th Annual Meeting Program Guide

40-Plat 10:00 am IMPACT OF UNSTRUCTURED N-TERMINUS OF 5-HT1B RECEPTOR ON SEROTONIN ACTION. Anthony Yasmann, Michael Nilges , Massimiliano Bonomi Platform Membrane Fusion and Organization 8:15 am - 10:15 am, South, Level Two, Room 204/205/206 Co-Chairs Kelly Lee, University of Washington, USA Sarah Shelby, University of Michigan, USA 41-Plat 8:15 am TRACKING STRUCTURAL INTERMEDIATES DURING CHIKUNGUNYA VIRUS MEMBRANE FUSION USING CRYO ELECTRON TOMOGRAPHY AND SUB-TOMOGRAM AVERAGING. Vidya Mangala Prasad, Jelle S. Blijleven, Jolanda M. Smit, Kelly K. Lee 42-Plat 8:30 am FISB RELIES ON HOMO-OLIGOMERIZATION AND LIPID BINDING TO CATA - LYZE MEMBRANE FISSION IN BACTERIA. Ane Landajuela , Martha Braun, Christopher Daniel Rodrigues, Alejandro Martínez-Calvo, Thierry Doan, Florian A. Horenkamp, Anna Andronicos, Vladimir Shteyn, Nathan D. Wil - liams, Chenxiang Lin, Ned S. Wingreen, David Rudner, Erdem Karatekin 43-Plat 8:45 am PREPARATION OF SARS-COV-2 VLP TO STUDY VIRAL ASSEMBLY, EGRESS, AND ENTRY. Jennifer D. Petersen, Glen Humphrey, Elena Mekhedov, Hang Waters, Joshua Zimmerberg 44-Plat 9:00 am SIMULATING MEMBRANE RESHAPING PROTEINS ON FUSION/FISSION PORES. Andrew H. Beaven , Nara L. Chon, Hai Lin, Jefferson Knight, Alexander J. Sodt 45-Plat 9:15 am HIGH-RESOLUTION MODELING OF NORMAL-TOPOLOGY MEMBRANE CONSTRICTION AND SCISSION DRIVEN BY ESCRT-III. James Lincoff , Frank R. Moss, Maxwell Tucker, Arshad Mohammed, Adam Frost, Michael Grabe 46-Plat 9:30 am MEMBRANE PHASE SEPARATION DRIVES ORGANIZATION AND ACTIVA - TION AT BCR SIGNALING COMPLEXES. Sarah A. Shelby , Ivan Castello Serrano, Kathleen C. Wisser, Ilya Levental, Sarah L. Veatch 47-Plat 9:45 am MOLECULAR MECHANISM OF FORMATION OF GPCR DOMAINS AT THE CELL SURFACE. Gabriele Kockelkoren , Line Lauritsen, Christopher Shuttle, Eleftheria Kazepidou, Artu' Breuer, Rachel Brunetti, Elisa D'Este, Orion Weiner, Mark J. Uline, Dimitrios Stamou 48-Plat 10:00 am MUTUAL REGULATION BETWEEN COUPLED ORDERED DOMAINS AND PROTEIN CONDENSATES. Kandice R. Levental , Hongyin Wang, Jonathon A. Ditlev, Michael K. Rosen, Ilya Levental Platform Cytoskeleton Dynamics and Regulation 8:15 am - 10:15 am, South, Level Two, Room 207/208 Co-Chairs Samantha Barrick, Washington University in St. Louis, USA Mariusz Matyszewski, University of California, San Diego, USA 49-Plat 8:15 am STRUCTURAL DIFFERENCES IN VINCULIN AND METAVINCULIN ACTIN- BINDING DOMAINS EXPLORED BY MOLECULAR DYNAMICS SIMULA - TIONS. Samantha K. Barrick , Michael J. Greenberg

50-Plat 8:30 am MECHANISM OF PARKINSON’S DISEASE-LINKED LRRK2 MICROTUBULE BINDING. Mariusz Matyszewski , David M. Snead, Andrea M. Dickey, Yu X. Lin, Andres E. Leschziner, Samara L. Reck-Peterson 51-Plat 8:45 am BIOCHEMICAL AND MECHANICAL CHARACTERIZATION OF BETA-ACTIN MUTANTS CAUSING NON-MUSCLE ACTINOPATHIES. Irene Pertici , Johannes N. Greve, Vincenzo Lombardi, Dietmar J. Manstein, Pasquale Bianco 52-Plat 9:00 am MICROTUBULES' LOCAL AND GLOBAL ORDER ON MEMBRANE-BOUND MOTOR PROTEINS. Fereshteh Memarian , Linda S. Hirst 53-Plat 9:15 am A MATLAB TOOLBOX FOR ULTRASTRUCTURAL ANALYSIS OF FILAMENT NETWORKS IN CRYO-ET DATA. Behnam am iri , Georgi Dimchev, Florian Fäßler, Martin Falcke, Florian K. Schur 54-Plat 9:30 am MICROTUBULE DETYROSINATION PROPAGATION AND ESTABLISHMENT REVEALED BY SINGLE-MOLECULE TRACKING AND SUPERRESOLUTION MICROSCOPY. Qing Tang , Arian Arab, Charles Bond, Melike Lakadamyali 55-Plat 9:45 am RECONSTITUTED ACTOMYOSIN NETWORKS IN LIPID BILAYER VESICLES SELF-ASSEMBLE INTO EMERGENT PATTERNS THAT DRIVE MEMBRANE DEFORMATION. Yashar Bashirzadeh , Allen Liu 56-Plat 10:00 am MAGNESIUM INCREASES THE CHEMO-MECHANICAL ENERGY RELEASED BY CURLING PROTOFILAMENTS DURING MICROTUBULE DISASSEMBLY. Lucas E. Murray , Haein Kim, Luke Rice, Charles L. Asbury Platform Muscle Electrophysiology I 8:15 am - 10:15 am, South, Level Two, Room 209/210/211 Co-Chairs Travel Award Winner ERO1Α-DEPENDENT ERP44 DISSOCIATION FROM RYR2 CONTRIBUTES TO CARDIAC ARRHYTHMIA. Shanna Hamilton , Radmila Terentyeva, Vladimir Bogdanov, Tae Yun Kim, Fruzsina Perger, Andriy E. Belevych, Christopher H. George, Jonathan P. Davis, Sandor Gyorke, Bum-Rak Choi, Dmitry Terentyev 58-Plat 8:30 am ACUTE PI(4,5)P 2 REGULATION OF CA V 1.2 L-TYPE CA 2+ CHANNELS IN THE HEART. Taylor L. Voelker , silvia Garcia del Villar, Maartje F. Westhoff, Andrea M. Coleman, Mary C. Horne, Johannes Hell, Eamonn J. Dickson, Rose E. Dixon 59-Plat 8:45 am ACTIVATION OF CARDIAC CONNEXIN 43 HEMICHANNELS BY SHEAR STRESS AND SUBSEQUENT CONTRIBUTION OF PANNEXINS IN LEFT-SIDE CARDIAC MYOCYTES. Long NH Do, Joon-Chul Kim, Sun-Hee Woo 60 -Plat 9:00 am AUTOSOMAL DOMINANT CPVT2 IS CAUSED BY IMPAIRED DYNAMIC CALCIUM BUFFERING IN THE SARCOPLASMIC RETICULUM. Matthew Wleklinski , Shan Parikh, Dmytro O. Kryshtal, Bjorn C. Knollmann 61-Plat 9:15 am DECREASED EPHAPTIC COUPLING DEPRESSES CARDIAC EXCITABILITY AND SLOWS CONDUCTION. Katrina Colucci-Chang , William Adams, Xiaobo Wu, Samarthya Bhagia, Arthur J. Ragauskas, Alexandra Hanlin, Gregory Hoeker, James P. Keener, Steven Poelzing Dmitry Terentyev, The Ohio State University, USA Eleonora Grandi, University of California, Davis, USA 57-Plat 8:15 am

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