Biophysical Society 66th Annual Meeting Program Guide

Protein Structure and Conformation I (Boards B1 - B34) 177-Pos Board B1 Travel Award Winner THE ROLE OF PTM CROSSTALKS IN HTTEX1 STRUCTURE, AGGREGATION AND MEMBRANE INTERACTION. Zhidian Zhang , Anass Chiki, Charlotte Gehin, Rajasekhar Kolla, Luciano A. Abriata, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro, Hilal A. Lashuel 178-Pos Board B2 EFFECT OF SAM68 KEY RESIDUE MUTATIONS ON ITS CONFORMATION AND STRUCTURE THAT MAY AFFECT SAM68-MEDIATED ECE-1B TRAN - SCRIPTION. Rory A. Greer , Gangjian Qin, Yuhua Song 179-Pos Board B3 SARS-COV-2 ANTIBODIES SPECIFIC TO THE MESA AND INNER SIDE OF SPIKE PROTEIN RECEPTOR BINDING DOMAIN MAINTAIN HIGH AF - FINITIES FOR BOTH D614G AND B.1.351 VARIANTS. Kan Li , Richard H.C. Huntwork, Gillian Q. Horn, Elizabeth Feeney, Kathryn M. Hastie, Haoyang Li, Vamseedhar Rayaprolu, Olmedillas Olmedillas, Sharon L. Schendel, Mark Heise, Ralph S. Baric, S. Munir Alam, Erica Ollmann Saphire, Georgia D. Tomaras, S. Moses Dennison 180-Pos Board B4 A YEAR IN THE LIFE OF SARS-COV-2 MPRO: MOLECULAR MODELING AND ANALYSIS OF CLINICALLY OBSERVED MPRO VARIANTS FROM THE FIRST YEAR OF THE COVID-19 PANDEMIC. Elizabeth M. Diessner , Gemma R. Takahashi, Thomas J. Cross, Carter T. Butts, Rachel W. Martin 181-Pos Board B5 AN ADAPTIVE APPROACH TO PREDICTING ANTIBODY-ANTIGEN COM - PLEX STRUCTURES FROM SEQUENCE. Daron Standley 182-Pos Board B6 SARS-COV-2 VARIANTS OF CONCERN DECELERATE THE DYNAMICS OF SPIKE OPEN CONFORMATION AS AN EVOLUTIONARY STRATEGY. Ziwei Yang, Yang Han, Shilei Ding, Andrés Finzi, Walther Mothes, Maolin Lu 183-Pos Board B7 AUTOMATED REFINEMENT PROTOCOL TO IMPROVE THE QUALITY OF PROTEIN STRUCTURES DEPOSITED IN THE PROTEIN DATA BANK, AP - PLIED TO SARS-COV-2. Joseph Farrell , Esmael J. Haddadian 184-Pos Board B8 DECREASED INTERFACIAL DYNAMICS CAUSED BY THE N501Y MUTATION IN THE SARS-COV-2 S1 SPIKE:ACE2 COMPLEX. Wesam S. Ahmed, Angelin M. Philip, Kabir H. Biswas 185-Pos Board B9 MOLECULAR DYNAMICS INVESTIGATION OF THE PH-DEPENDENT IN - FLUENZA HEMAGGLUTININ CONFORMATIONAL CHANGE. Shadi Badiee , Vivek Govid Kumar, Adithya Polasa, Mahmoud Moradi 186-Pos Board B10 STRUCTURAL INSIGHTS INTO RAG GTPASE ACTIVATION BY FLCN:FNIP2. Rachel M. Jansen , Adam Yokom, Simon Fromm, James H. Hurley 187-Pos Board B11 STRUCTURE AND FUZZINESS IN THE WIP-CORTACTIN REGULATORY COMPLEX. Chana G. Sokolik, Jordan H. Chill 188-Pos Board B12 STRUCTURE-FUNCTION RELATIONSHIP OF AN UNSTRUCTURED PRO - TEIN: Α-SYNUCLEIN. Eitan Lerner , Nikolay V. Dokholyan, Paul D. Harris, Khalil Joron, Paz Drori, Joanna Zamel, Jiaxing Chen, Sofia Zaer

189-Pos Board B13 THE VARIABLE DOMAIN FROM THE MITOCHONDRIAL FISSION MECHA - NOENZYME DRP1 PROMOTES LIQUID-LIQUID PHASE SEPARATION. Blake Hill , Ammon E. Posey, MEHRAN BAGHERI, Megan C. Harwig, Nolan W. Kennedy, Vincent J. Hilser, James L. Harden 190-Pos Board B14 Travel Award Winner ELUCIDATING THE STRUCTURAL DETERMINANT OF CELSR1 FUNCTION INVOLVED IN PLANAR CELL POLARITY. Elakkiya Tamilselvan , Marcos Sotomayor 191-Pos Board B15 STRUCTURE AND BINDING OF AN EXOGENOUS SIDEROPHORE BY A RE - CEPTOR PROTEIN IN A GUT COMMENSAL BACTERIUM. Yasiru R. Perera , Brian Ferrer, Wenhan Zhu, Walter J. Chazin 192-Pos Board B16 MICROTITER BINDING ASSAYS AND IN SILICO KINETIC MAPPING REVEAL BINDING OF TDP-43 NUCLEAR LOCALIZATION SIGNAL TO IMPORTIN Α IS MODULATED BY PHOSPHORYLATION. Hamed Meshkin, Alexander J. Bryer , Steven G. Doll, Gino Cingolani, Juan R. Perilla 193-Pos Board B17 UNRAVELING THE STRUCTURAL BASIS OF SELECTIVE INHIBITION OF HU - MAN CYTOCHROME P450 3A5. Jingheng Wang , Cameron D. Buchman, Jayaraman Seetharaman, Darcie J. Miller, Andrew D. Huber, Jing Wu, Sergio C. Chai, Efren Garcia-Maldonado, William C. Wright, Jude Chenge, Taosheng Chen 194-Pos Board B18 HDX-MS GUIDED ENSEMBLE REWEIGHTING APPROACH TO CHARACTER - IZE THE NATIVE STATE ENSEMBLE OF THE CYTOPLASMIC HEME BINDING PROTEIN, PHUS. Kyle C. Kihn , Tyree Wilson, Ally K. Smith, Richard T. Bradshaw, Wenbo Yu, Patrick L. Wintrode, Alexander D. MacKerell, Lucy R. Forrest, Angela Wilks, Daniel Deredge 195-Pos Board B19 INTER-DOMAIN LINKERS MODULATE SUPERTERTIARY STRUCTURAL DYNAMICS IN THE N-TERMINAL PDZ TANDEM OF PSD-95. George L. Hamilton , Nabanita Saikia, Brie Levesque, Rajen K. Goutam, Changcheng Zhang, Hugo Sanabria, Mark E. Bowen, Feng Ding 196-Pos Board B20 A STRUCTURE-FUNCTION APPROACH TO ELUCIDATE THE MOLECULAR MECHANISM OF THE TELOMERE C-STRAND FILL-IN PROCESS. Qixiang He , Andrey Baranovskiy, Xiuhua Lin, Ben Lusk, Victoria Tholkes, Tahir Tahirov, Ci Ji Lim 197-Pos Board B21 DIFFERENTIAL INTERACTIONS BETWEEN HUMAN ACE2 AND SPIKE RBD OF SARS-COV-2 VARIANTS OF CONCERN. Seonghan Kim , Yi Liu, Zewei Lei, Jeffrey Dicker, Yiwei Cao, Xiaohui Zhang, Wonpil Im 198-Pos Board B22 HIGHER-ORDER STRUCTURE ANALYSIS OF HIGH CONCENTRATION MONOCLONAL ANTIBODY BY CIRCULAR DICHROISM (CD) AND IFRARED (IR) SPECTROSCOPY. Ai Yamane , Taiji Oyama, Kohei Tamura, Miyuki Kanno, Shingo Norimoto, Forrest Kohl, Satoko Suzuki, Kenichi Akao 199-Pos Board B23 DETERMINANTS OF E3 LIGASE ADAPTOR SPOP BINDING TO INTRINSI - CALLY DISORDERED SUBSTRATES. Emery T. Usher , Scott A. Showalter 200-Pos Board B24 A C 2 -SYMMETRIC STATE IN THE AAA+ KAIC HEXAMER COORDINATES STRUCTURAL AND FUNCTIONAL MODES WITHIN A MOLECULAR CLOCK. Alfred M. Freeberg , Jeffrey A. Swan, Colby Sandate, Archana G. Chavan, Dustin Ernst, Diana Etwaru, Joseph G. Palacios, Susan Golden, Andy LiWang, Gabriel C. Lander, Carrie L. Partch

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