Biophysical Society 66th Annual Meeting Program Guide

214-Pos Board B38 ASSESSMENT OF PREDICTION METHODS FOR PROTEIN STRUCTURES DETERMINED BY NMR IN CASP14: IMPACT OF ALPHAFOLD2. Yuanpeng Janet Huang , Ning Zhang, Beate Bersch, Krzysztof Fidelis, Masayori In - ouye, Yojiro Ishida, Andriy Kryshtafovych, Naohiro Kobayashi, Yutaka Ku - roda, Gaohua Liu, Andy LiWang, G.V.T. Swapna, Nan Wu, Toshio Yamazaki, Gaetano T. Montelione 215-Pos Board B39 NOVEL SEQUENCE SPACE EXPLORED BY FUNCTIONAL PROTEINS GENER - ATED THROUGH COMPUTATIONAL EVOLUTION-BASED DESIGN. Sophia Alvarez , Charisse Nartey, Nicholas Mercado, Faruck Morcos 216-Pos Board B40 DE NOVO DESIGN OF A Β-LACTAMASE IN A MODULAR HELICAL BUNDLE PROTEIN SCAFFOLD. Samuel H. Schneider , William DeGrado 217-Pos Board B41 FROM BARNYARD TO BEDSIDE: USING INTERSPECIES VARIANTS TO INFORM THE RATIONAL DESIGN OF NOVEL ANALOGS OF ISLET AMYLOID POLYPEPTIDE. Matthew E.T. Miller , Rehana Akter, Alexander Zhyvoloup, Rebekah L. Bower, Andisheh Abedini, Debbie L. Hay, Daniel P. Raleigh 218-Pos Board B42 EVOLUTIONARY LANDSCAPES DERIVED FROM AMINO ACID SEQUENCE SPACE SERVE AS PREDICTIVE MODELS OF FUNCTIONAL PHENOTYPES IN PROTEIN DESIGN. Faruck Morcos 219-Pos Board B43 INTEGRATION OF PROTEIN ENGINEERING WITH MACHINE LEARNING TO INCREASE THE EFFICIENCY OF DRUG DISCOVERY. Joelle Eaves , Mehrsa Mardikoraem, Daniel R. Woldring 220-Pos Board B44 DESIGNING A PDZ CHELATOR FOR ALZHEIMER’S PEPTIDES BASED ON THE KNOB-SOCKET MODEL. Calvin Vuong, Colby Vuong , Hyun Joo, Jerry Tsai 221-Pos Board B45 DESTABILIZING TROPOMYOSIN-TROPONIN I INTERACTIONS INCREASES CALCIUM SENSITIVITY. Meaghan E. Barry , Michael J. Rynkiewicz, Elumalai Pavadai, William Lehman, Jeffrey R. Moore 222-Pos Board B46 IDENTIFYING THE BINDING DETERMINANTS FOR ANTI-CANCER BH3 MIMETIC. Jennifer Yi 223-Pos Board B47 DEFINING THE DNA BINDING MODE OF DNASE1L3 AND MODIFYING THE ENZYME TO BE USED AS A THERAPEUTIC. Johanna Villarreal , Jon J. Mc - Cord, Minal Engavale, Britney Mapp, Peter Keyel, Roger B. Sutton 224-Pos Board B48 Travel Award Winner REDEFINING THE ARCHITECTURE OF FERLIN PROTEINS. Matthew J. Dominguez , Jon J. McCord, Roger B. Sutton 225-Pos Board B49 Travel Award Winner MOLECULAR ADAPTATIONS OF PSYCHROPHILIC SERINE PROTEASES. Gemma R. Takahashi , Elizabeth M. Diessner, Omar J. Akbari, Jonathan Le, Carter T. Butts, Rachel W. Martin 226-Pos Board B50 DISMANTLING ANTIBIOTIC RESISTANCE ONE VARIANT AT A TIME: IN VITRO AND COMPUTATIONAL ANALYSIS OF VAT D . Alexis M. Kelley , Chris - tian B. Macdonald, James Fraser 227-Pos Board B51 BINDING REACTION INVESTIGATION OF DESIGNED MINIPROTEINS USING METADYNAMICS AND MASSIVELY PARALLEL AB-INITIO SIMULA - TION. Dylan Novack , Paula Garavito, Frank D. Teets, Christopher D. Bahl, Vincent Voelz

201-Pos Board B25 CONFORMATIONAL DYNAMICS OF THE EBOLA VIRUS GLYCOPROTEIN (GP) UNDER CONDITIONS RELEVANT FOR MEMBRANE FUSION. Natasha D. Durham , James B. Munro 202-Pos Board B26 ALTERATION OF AN OBLITERATED INTERFACE IN A CLASSICAL ALLOSTE - RIC PROTEIN CAUSES UNEXPECTED FUNCTIONAL CHANGES. Antonio Tsuneshige 203-Pos Board B27 Travel Award Winner INTEGRATIVE STRUCTURAL DYNAMICS OF CALMODULIN SHOWCASES SEQUENCE-TO-FUNCTION. Narendar Kolimi , Aishwarya Krishnamohan, Rajen Goutam, Faruck Morcos, Hugo Sanabria 204-Pos Board B28 STUDY OF ZN(II) EFFECT ON AMYLIN AGGREGATION. Diana A. Cruzalta , Lina A. Rivillas-Acevedo 205-Pos Board B29 CONFORMATIONAL CHANGES IN SARS-COV-2 SPIKE FROM THE DELTA VARIANT ENHANCES VIRAL TRANSMISSIBILITY. Varun Venkatakrishnan , Sean Braet, Theresa Buckley, Ganesh S. Anand 206-Pos Board B30 STRUCTURAL CHARACTERIZATION OF FOLDING OF GBX WITH FOCUS ON INTRINSIC PARAMETERS INFLUENCE PROTEIN STABILITY. Rifat Farhana , Jaroslava Miksovska, Francisco Fernandez-Lima, Khoa Pham, Sophie Bernad, Vallerie Derrien 207-Pos Board B31 BIOPHYSICAL CHARACTERIZATION OF METAL BINDING IN PPC FAMILY OF CYTOCHROMES. Sophia Gross , Tyler Brittain, Oleksandr Kokhan 208-Pos Board B32 IMPACT OF MUTATIONS NEAR THE SARS-COV-2 FURIN-CLEAVAGE SITE ON VIRAL INFECTIVITY. Kien Nguyen , Srirupa Chakraborty, Pedro D. Manrique, Bette Korber, S. Gnanakaran 209-Pos Board B33 DESIGN AND ENGINEERING OF PHOTO-CONTROLLED REP HELICAS - ES. Sonisilpa Mohapatra , Tunc Kayikcioglu, Chang-Ting Lin, Taekjip Ha 210-Pos Board B34 CHANGES IN THE RECEPTOR-BINDING INTERFACE MAY CAUSE IMMUNE EVASION BY THE SARS-COV-2 DELTA VARIANT B.1.617.2. Prabin Baral , Nisha Bhattarai, Md Lokman Hossen, Vitalii Stebliankin, Bernard S. Gerstman, Giri Narasimhan, Prem P. Chapagain Protein Structure, Prediction, and Design (Boards B35 - B57) 211-Pos Board B35 DETERMINING THE MECHANISM OF A SPECTRAL SHIFT IN CONE VISUAL PIGMENTS USING ATOMISTIC MOLECULAR SIMULATIONS. Peik K. Lund- Andersen , F. Marty Ytreberg, Jagdish S. Patel 212-Pos Board B36 LEARNING COEVOLUTIONARY MODELS FOR PROTEIN DESIGN. Layne B. Frechette , Robert B. Best 213-Pos Board B37 ASSESSING STRUCTURE AND DYNAMICS OF ALPHAFOLD2 PREDICTION OF GEOCAS9. Pablo R. Arantes , Lukasz Nierzwicki, Helen Belato, Alexan - dra M. D'Ordine, Gerwald Jogl, George Lisi, Giulia Palermo

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