Biophysical Society 66th Annual Meeting Program Guide

242-Pos Board B66 A COMPUTATIONAL INSIGHT INTO HOW HUMAN SERUM CARNOSINASE 1 RECOGNISES CARNOSINE AND ANSERINE. Borvornwat Toviwek, Thana - thip Suwanasopee, Skorn Koonawootrittriron, Prapasiri Pongprayoon 243-Pos Board B67 EXPLORING THE RELATIONSHIP BETWEEN LC8 AND VIRAL PHOSPHOPRO - TEINS. Gretchen Fujimura 244-Pos Board B68 MODELING STATE-DEPENDENT AND STEREOSPECIFIC INTERACTIONS OF BETA-BLOCKERS WITH THE BETA-ADRENERGIC RECEPTOR FOR MUL - TISCALE MODELING. John R.D. Dawson , Kyle C. Rouen, Yanxiao Han, Gonzalo Hernandez Hernandez, Pei-Chi Yang, Borislava Bekker, Colleen E. Clancy, Igor Vorobyov 245-Pos Board B69 UNDERSTANDING LIGAND SPECIFICITY THROUGH PROTEIN NETWORK DYNAMICS. Paul Campitelli , S. Banu Ozkan, Liskin Swint-Kruse 246-Pos Board B70 CHARACTERIZATION OF THE INTERACTION BETWEEN TCMN AND PROD - UCT ANALOGS. Veronica S. Valadares , Luan C. Martins, Adolfo H. Moraes, Elio A. Cino 247-Pos Board B71 EXPLORING DRUG ARRYTHMOGENICITY VIA ATOMISTIC SIMULATIONS OF STATE-SPECIFIC HERG-CHANNEL BLOCK. Kyle C. Rouen , Khoa Ngo, Abhishek A. Kognole, John R.D. Dawson, Borislava Bekker, Vladimir Yarov- Yarovoy, Alexander D. MacKerell, Igor Vorobyov 248-Pos Board B72 SUBUNIT CONFORMATION MODULATES THE CONCENTRATION OF CO 2 IN THE ACTIVE SITE OF THE MOST EFFICIENT CARBOXYLASE. Aharon I. Gomez Llanos , Helmut Grubmueller, Esteban Vöhringer-Martinez 249-Pos Board B73 SALT BRIDGE FORMATION BY PHTHALATE METABOLITES IN PPAR-GAM - MA NUCLEAR RECEPTOR REVEALS A POTENTIAL MODE OF TOXICITY. Andres S. Arango , Daryl D. Meling, Jodi A. Flaws, Emad Tajkhorshid 250-Pos Board B74 BIASED METABOLISM VIA SMALL-MOLECULE LIGANDS BINDING TO P450 OXIDOREDUCTASE. Nikos S. Hatzakis , Simon B. Jensen, Sara Thodberg, Shaheena Parween, Matias E. Moses, cecillie C. Hansen, Camilla Knudsen, Rita D. Giudice, Philip M. Lund, Patricia Castano, Yanet G. Bustamante, Flemming S. Jorgennsen, Amit V. Pandey, Tomas Laursen, Birger L. Møller 251-Pos Board B75 CYP P450 MEDIATED METABOLISM OF PHYTOCANNABONOIDS LEADS TO THE PRODUCTION OF BIOACTIVE METABOLITES. Pritam Roy , Hannah C. Huff, Archit K. Vasan, David G. Dennis, Emad Tajkhorshid, David Sarlah, Board B76 BIOMECHANICS AND MOLECULAR MECHANISMS OF AGING IN ELAS - TIN. Chengeng Yang , Anna Tarakanova 253-Pos Board B77 ALLOSTERIC EFFECT OF NANOBODY BINDING ON LIGAND-SPECIFIC ACTIVE STATES OF THE Β2-ADRENERGIC RECEPTOR. Yue Chen , Oliver Fleetwood, Sergio Pérez Conesa, Lucie Delemotte 254-Pos Board B78 UTILIZING A PH-DEPENDENT REACTION TRIGGERING METHOD TO ELU - CIDATE THE MECHANISM OF BACTERIAL HMG-COA REDUCTASE USING TIME-RESOLVED CRYSTALLOGRAPHY. Vatsal Purohit , Calvin Steussy, Tim Schmidt, Chandra J. Duncan, Tony Rosales, Paul Helquist, Olaf Wiest, Cynthia V. Stauffacher Aditi Das 252-Pos

228-Pos Board B52 IN SITU REPLACEMENT OF SLOW SKELETAL MYOSIN BINDING PROTEIN- C. John Sullivan , Rachel Sadler, Joshua Strom, Samantha Harris 229-Pos Board B53 KNOB-SOCKET PACKING INVESTIGATION OF BZIP PROTEIN DIMERIZA - TION. Christopher Argueta 230-Pos Board B54 EVALUATION AND DESIGN OF CONFORMATIONALLY STABLE HALOGEN- SUBSTITUTED BETA-HAIRPINS USING MOLECULAR SIMULATION. Thi Dung Nguyen , Robert Raddi, Mate Erdelyi, Vincent Voelz 231-Pos Board B55 HIGH ACCURACY ACHIEVED PREDICTING STABILIZING SURFACE MUTA - TIONS IN UBA(1). Mike T. Rothfuss , Dustin C. Becht, Baisen Zeng, Levi J. McClelland, Cindee Yates-Hansen, Bruce E. Bowler 232-Pos Board B56 USING PROTEIN STRUCTURE PREDICTION WITH MOLECULAR PHYLO - GENETIC ANALYSIS TO UNDERSTAND MEMBRANE INTERACTIONS IN SYNAPTOTAGMIN-LIKE PROTEINS. Nara L. Chon, Sherleen Tran, Christo - pher S. Miller, Hai Lin, Jefferson Knight 233-Pos Board B57 INSULIN ANALOGS DERIVED FROM VENOMOUS INSULIN-LIKE PEP - TIDES. Biswajit Gorai, Harish Vashisth Protein-Small Molecule Interactions I (Boards B58 - B85) 234-Pos Board B58 STANDARD ERRORS OR ASYMMETRIC CONFIDENCE INTERVALS OF THE PROTEIN-LIGAND BINDING CONSTANT. Vaida Paketuryte-Latve, Vytautas Petrauskas, Asta Zubriene, Daumantas Matulis 235-Pos Board B59 ACCOUNTING FOR CHANGES IN HYDRATION ENERGY: MODEL BINDING REACTIONS SUPPORT NEW APPROACH TO EQUILIBRIUM THERMODY - NAMICS. Daryl K. Eggers 236-Pos Board B60 Travel Award Winner COMPARISON OF DIFFERENT FORCE FIELD COMBINATIONS FOR LIGAND BINDING FREE ENERGY CALCULATIONS WITH AMBER. Han Zhang , Seong - hoon Kim, Wonpil Im 237-Pos Board B61 INDUCED FIT DOCKING WORKFLOW BASED ON CHARMM-GUI MODULES: LBS FINDER & REFINER AND HIGH-THROUGHPUT SIMULATOR. Hugo Guterres , Wonpil Im 238-Pos Board B62 WHEN DOES BELL'S MODEL FOR UNBINDING KINETICS FAIL? Willmor J. Pena 239-Pos Board B63 AMOEBA-IONS: IMPROVED DESCRIPTION OF HIGH FIELD POLARIZATION FOR INTERACTIONS OF PROTEINS WITH MONOVALENT CATIONS. Julian A. Melendez , Vered Wineman-Fisher, Sameer Varma 240-Pos Board B64 COORDINATION OF AGE-RELATED MACULAR DEGENERATION PATHO - GENESIS BY VITRONECTIN. Kyungsoo Shin , James E. Kent, Alexander E. Aleshin, Ye Tian, Lynn M. Fujimoto, Chandan Singh, Francesca M. Marassi 241-Pos Board B65 ELECTROPHILIC STEROL ANALOG INHIBITORS TARGETING AUTOPROCESS - ING DOMAIN OF HEDGEHOG PROTEIN. Zihan Xu , Brian Callahan, John Pezzullo, Jose' Giner

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