Biophysical Society 66th Annual Meeting Program Guide

255-Pos Board B79 ANTIVIRAL COMPOUNDS INVESTIGATED BY SOLID-STATE DEUTERIUM NMR SPECTROSCOPY. Ankan Nath , Soohyun Lee, Trivikram R. Molugu, Jun Wang, Andrey V. Struts, Michael F. Brown 256-Pos Board B80 EXAMINING ENZYME ACTIVE SITE DYNAMICS USING LINEAR AND NON - LINEAR INFRARED SPECTROSCOPY: SUBSTRATE ORIENTATION, COFACTOR COMPOSITION, AND SOLVENT EFFECTS. Sunil Basnet , Hannah H. Lepird, Tayler D. Hill, Sean D. Moran 257-Pos Board B81 EXPLORING THE STRUCTURAL DETERMINANTS FOR INHIBITOR SELECTIV - ITY TOWARDS THE BACE PROTEIN FAMILY USING STRUCTURE-BASED MOLECULAR DESIGN. Emma K. Lendy , Yu-Chen Yen, Emilio L. Cardenas, Margherita Brindisi, Arun K. Ghosh, Andrew D. Mesecar 258-Pos Board B82 CHARACTERIZING OXIODOREDUCTASE PYROX-D1. Isaac L. Scott , Roger B. Sutton, Sandra Cooper 259-Pos Board B83 EXPLORING THE KINETICS OF THE WIN-SITE OF WDR5. Ali Imran , Bran - don S. Moyer, Ashley Canning, Dan Kalina, Thomas Duncan, Kelsey J. Moody, Aaron Wolfe, Michael S. Cosgrove, Liviu Movileanu 260-Pos Board B84 BIOCHEMICAL INVESTIGATION OF THE IMPACT OF ZCL278 ON CDC42/ ACK INTERACTION. Emilio Duverna 261-Pos Board B85 INVESTIGATION OF THE CHARACTERISTIC BINDING MODE OF PROSTA - GLANDIN ENDOPEROXIDE H 2 FORMED BY CYCLOOXYGENASE WITH A GROUP OF TERMINAL PROSTANOID SYNTHASES. Inseok Song Intrinsically Disordered Proteins I (Boards B86 - B113) 262-Pos Board B86 SYNERGISTIC INTERACTIONS BETWEEN Α-SYNUCLEIN AND PRION-LIKE C-TERMINAL DOMAIN OF TDP-43. Shailendra Dhakal , Vijay Rangachari 263-Pos Board B87 THE PROTECTIVE ROLE OF THE FLANKING DOMAINS IN Α-SYNUCLEIN MONOMERS. Frank X. Vázquez , Noriyo Onishi 264-Pos Board B88 IDENTIFYING DIFFERENCES IN DYNAMICS AND RESIDUAL STRUCTURE OF THE INTRINSICALLY DISORDERED DOMAINS OF Α-SYNUCLEIN MONOMER AND FIBERS. Sayuri Pacheco 265-Pos Board B89 MOLECULAR DYNAMICAL ANALYSIS OF POTENTIAL DIMERS PRODUCED BY C55 PORTION OF THE AMYLOID PRECURSOR PROTEIN. Ishaan Roy , Joseph Farrell, Esmael J. Haddadian 266-Pos Board B90 MULTISCALE SIMULATIONS REVEAL MOLECULAR DYNAMICS OF TDP-43 ASSEMBLIES. Helgi I. Ingólfsson , Azamat Rizuan, Priyesh Mohanty, Jeetain Mittal, Joel Berry 267-Pos Board B91 STRUCTURAL CHARACTERIZATION OF FIBRILS FORMED BY THE LOW COMPLEXITY DOMAIN OF THE RNA-BINDING PROTEIN TIA-1. Yuuki Wittmer , Dylan T. Murray 268-Pos Board B92 MICROSECOND DYNAMICS DURING THE BINDING-INDUCED FOLDING OF AN INTRINSICALLY DISORDERED PROTEIN. Sreemantee Sen , Harish Kumar, Jayant B. Udgaonkar

269-Pos Board B93 EFFECTS OF VESICULAR MEMBRANE COMPOSITION ON AMYLOID-BETA OLIGOMERIZATION. Jhinuk Saha , Priyankar Bose, Shailendra Dhakal, Preetam Ghosh, Vijay Rangachari 270-Pos Board B94 Travel Award Winner A NEUROHYPOPHYSEAL HORMONE ANALOG MODULATES THE AMYLOID AGGREGATION OF HUMAN PRION PROTEIN. Nikita Admane , Abhinav Grover 271-Pos Board B95 DO AMYLOID OLIGOMERS MAKE A REGULAR STRUCTURE IN THE LIPID MEMBRANE? Vicky Vishvakarma , Arpan Dey, Vinayak Rane, Ravindra Venkatramani, Sudipta Maiti 272-Pos Board B96 MEASURING THE ENERGETIC PENALTY OF FOLDING AND BINDING BE - TWEEN P53 AND MDM2. Pirada S. Higbee 273-Pos Board B97 ELECTROSTATIC AND SPECIFIC INTERACTIONS CONTRIBUTE TO INHIBI - TION OF DNA BINDING VIA AN INTRAMOLECULAR INTERACTION IN P53. Emily Gregory-Lott , Mi Zhou, Jianfeng Cai, Jiandong Chen, Gary W. Daughdrill 274-Pos Board B98 CHARACTERIZING THE SEQUENCE DETERMINANTS OF PROTEIN DISOR - DER & ITS IMPACT ON VIRULENCE PROTEIN SECRETION. Cedrick Mukinay , Micayla Bowman, Michael Baxa, Tobin R. Sosnick, Patricia L. Clark 275-Pos Board B99 PATHOLOGICAL AND PROTECTIVE MUTATIONS IN APOE DIFFER SUBSTAN - TIALLY BETWEEN SPECIES AND RESULT IN CONFORMATIONALLY DISTINCT ENSEMBLES. Greg W. Gomes, Zachary Levine 276-Pos Board B100 PATHOLOGICAL AND PROTECTIVE ISOFORMS OF APOE ADOPT DISTINCT CONFORMATIONS IN THE PRESENCE OF LIPIDS. Greg W. Gomes , Zachary Levine 277-Pos Board B101 THE ROLE OF THE NF-KAPPA B TRANSCRIPTION ACTIVATION DOMAIN IN SPECIFIC AND NONSPECIFIC DNA INTERACTIONS. Hannah E. R. Baughman , Amalia C. Villagran Suarez, Joan Lee, Elizabeth A. Komives 278-Pos Board B102 DOMAIN CAMOFLOUGE OF C-SRC: SEGMENTAL LABELING HIGHLIGHTS ONCOPROTEIN DOMAINS FOR NEUTRON SCATTERING. Viswanathan Gurumoorthy , Utsab Shrestha, Sai Venkatesh Pingali, Jeremy C. Smith, Volker Urban, Loukas Petridis, Hugh M. O'Neill 279-Pos Board B103 THE HIGHLY DISORDERED PROTEIN PROTHYMOSIN ALPHA AS A NOVEL NEUROPROTECTOR OF THE BRAIN. Catarina B. Fernandes , Birthe B. Kragelund 280-Pos Board B104 CHARACTERIZATION OF THE WW-DOMAIN/PPXY MEDIATED ASSEMBLY AND REGULATION OF THE SALVADOR/WARTS/YORKIE MULTIPROTEIN COMPLEX IN HIPPO SIGNALING. Sanjay Ramprasad 281-Pos Board B105 DISTANT ELECTROSTATIC INTERACTIONS DOMINATE THE DYNAMICS OF THE DISORDERED MEASLES VIRUS NTAIL. John Kunkel, Gerdenis Kodis, Gabor Nagy, Christophe Bignon, Lillian Otteson, Sonia Longhi, Andrea C. Vaiana, Helmut Grubmuller, Wenwei Zheng, Sara M. Vaiana 282-Pos Board B106 THE IMPACT OF METALS ON THE STRUCTURE AND DYNAMICS OF THE TAIL DOMAIN OF VIMENTIN. Estely Carranza , Dylan T. Murray

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