Biophysical Society 66th Annual Meeting Program Guide

479-Pos Board B303 FUNCTIONAL EFFECTS OF A LETHAL MUTATION (R1667P) IN THE VOLT - AGE-SENSING S4 Α-HELIX OF REPEAT IV OF CAV2.1. Benjamin J. Grosso , Sidharth Tyagi, Daniel Bennett, Ulises Meza, Michael Wangler, Roger A. Bannister 480-Pos Board B304 COMPUTATIONAL AND EXPERIMENTAL STUDY OF A FIRST-IN-CLASS, POSI - TIVE ALLOSTERIC MODULATOR THAT TARGETS CAV2.1 VOLTAGE-GATED CALCIUM CHANNELS. Rozita Laghaei , Stephanie B. Aldrich, Stephen D. Board B305 THE VOLTAGE DEPENDENT STRUCTURAL REARRANGEMENTS OF THE FOUR VOLTAGE SENSING DOMAINS OF THE HUMAN T-TYPE CA V 3.1 CHANNEL. Moira McVicar, Marina Angelini, Nicoletta Savalli, Scott John, Michela Ottolia, Riccardo Olcese 482-Pos Board B306 DISRUPTED REGULATION OF VOLTAGE-GATED CALCIUM CHANNELS BY PATHOGENIC CALMODULIN VARIANTS. John W. Hussey , Emily DeMarco, Deborah DiSilvestre, Helene H. Jensen, Mette Nyegaard, Michael T. Over - gaard, Ivy E. Dick 483-Pos Board B307 Travel Award Winner LQT8 MUTATIONS INDUCE ACTION POTENTIAL PROLONGATION AND ARRHYTHMIA IN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIO - MYOCYTES. Daiana C.O. Vieira , Josiah O. owoyemi, Deborah DiSilvestre, Moradeke A. Bamgboye, Ivy E. Dick 484-Pos Board B308 Travel Award Winner ANTISENSE OLIGONUCLEOTIDES AS A TREATMENT STRATEGY FOR TIMO - THY SYNDROME. Josiah O. Owoyemi , Maria K. Traficante, Moradeke A. Bamgboye, Deborah DiSilvestre, Daiana C.O. Vieira, Ivy E. Dick 485-Pos Board B309 Travel Award Winner MOLECULAR MECHANISMS RESPONSIBLE FOR THE SEXUAL DIMOR - PHISM IN PANCREATIC Β-CELL INSULIN RELEASE. Noelia Jacobo-Piqueras , Tamara Theiner, Stefanie M. Geisler, Petronel Tuluc 486-Pos Board B310 MISSENSE MUTATIONS IN VOLTAGE-GATED CALCIUM CHANNELS AS - SOCIATED WITH NEURODEVELOpmENTAL AND NEURODEGENERATIVE DISORDERS. Yuliia V. Nikonishyna , Nadja T. Hofer, Nadine J. Ortner, Teresa Kaserer, Jessica Hoffman, Saskia Biskup, Manuel Dafotakis, Jörg B. Schulz, Maike F. Dohrn, Jörg Striessnig TRP Channels (Boards B311 - B327) 487-Pos Board B311 THE DISORDERED C-TERMINAL TAIL OF TRPA1 IS REQUIRED FOR CALMODULIN BINDING AND DESENSITIZATION. Justin H. Sanders , Can - dice E. Paulsen 488-Pos Board B312 Travel Award Winner TRPC6 CHANNEL INTERACTS WITH THE RBD DOMAIN OF RHOTEKIN AND REGULATES RHOA ACTIVITY. Boris J. Lavanderos , Mariela González, Ariela Vergara-Jaque, Oscar Cerda 489-Pos Board B313 MOLECULAR DETAILS OF TRPV5 MODULATION BY PROTEIN KINASE A AND PH. Edwin C. Fluck , Aysenur T. Yazici, Tibor Rohacs, Vera Moiseenko - va-Bell 490-Pos Board B314 DISTINCT OPEN STATES OF TRPV1 INDUCED BY CAPSAICIN AND RTX. Shisheng Li , Simon Vu, Jie Zheng Meriney 481-Pos

466-Pos Board B290 HYDROPHOBIC RESIDUES IN S6 SEGMENTS OF NAV CONTRIBUTE TO THE FAST INACTIVATION GATE. Yichen Liu , Francisco Bezanilla 467-Pos Board B291 STRUCTURE AND FUNCTION OF THE HUMAN NALCN-UNC79-UNC80- FAM155A-CAM COMPLEX. Han Chow Chua , Marc Kschonsak, Claudia Weidling, Nourdine Chakouri, Cameron L. Noland, Katharina Schott, Tim - othy Chang, Christine Tam, Nidhi Patel, Christopher P. Arthur, Alexander Leitner, Manu Ben-Johny, Claudio Ciferri, Stephan A. Pless, Jian Payandeh 468-Pos Board B292 CHARACTERIZING GATING DEFECTS OF SCN2A COUNTERCHARGE MUTA - TIONS IN EPILEPSY SYNDROMES. James R. Groome , Sarah N. Brockway 469-Pos Board B293 BIOPHYSICAL CHARACTERIZATION OF SCN1A AND SCN2A VARIANTS RE - LATED TO EPILEPSY. Xiao-Ru Yang, Hugo Poulin, Valérie Pouliot, Quentin Plumereau, Juan Pablo Appendino, Ping Yee Billie Au, Mohamed Chahine Voltage-Gated Ca Channels (Boards B294 - B310) 470-Pos Board B294 A FUNCTIONAL SCREEN REVEALS STAC2 AS A NOVEL REGULATOR OF THE NALCN CHANNELOSOME. Han Chow Chua , Peilin Tu, Katharina Schott, Stephan A. Pless 471-Pos Board B295 STAC PROTEINS INHIBIT CALCIUM AND VOLTAGE DEPENDENT INACTIVA - TION OF L-TYPE CALCIUM CHANNELS. Wietske E. Tuinte , Petronel Tuluc, Bernhard E. Flucher, Marta Campiglio 472-Pos Board B296 OSCILLATORY TRANSCRIPTIONAL ACTIVITY OF CARDIAC L-TYPE CA 2+ CHANNEL. Estelle Personnic , Romain Perrier, Ana M. Gomez, Jean-Pierre Board B297 UNTETHERING THE CA V CHANNEL ß2A SUBUNIT FROM THE MEMBRANE: THE ROLE OF DEPALMITOYLASES. Srinidhi Jayaraman , Manu Ben-Johny 474-Pos Board B298 NIFEDIPINE BINDING TO HUMAN CA V 1.1 ALLOSTERICALLY SETS 3 OUT OF 4 VOLTAGE SENSORS INTO THEIR "RELAXED STATE". Marina Angelini , Nicoletta Savalli, Federica Steccanella, Riccardo Olcese 475-Pos Board B299 ALTERED CA V 1.2 TRAFFICKING CONTRIBUTES TO Β-ADRENERGIC RE - CEPTOR HYPO-RESPONSIVITY IN THE AGING MYOCARDIUM. Maartje Westhoff , Silvia G. del Villar, Taylor L. Voelker, Eamonn J. Dickson, Rose E. Dixon 476-Pos Board B300 EVALUATING THE IMPACT OF CA V 1.2 MUTATIONS ON NEURONAL FUNC - TION. Kevin G. Herold , Moradeke A. Bamgboye, Daiana C.O. Vieira, Debo - rah DiSilvestre, John W. Hussey, Josiah O. owoyemi, Andrea L. Meredith, Ivy E. Dick 477-Pos Board B301 Travel Award Winner CA V 1.3 L-TYPE CA 2+ CHANNEL MODULATES PANCREATIC Β-CELL ELECTRI - CAL ACTIVITY AND SURVIVAL. Tamara Theiner , Noelia Jacobo-Piqueras, Nadine J. Ortner, Stefanie Geisler, Petronel Tuluc 478-Pos Board B302 THE CA V 2.1 II-III LOOP BINDS TO BOTH JUNCTOPHILIN 3 AND JUNC - TOPHILIN 4. Stefano Perni , Alexander Polster, Kurt G. Beam Benitah 473-Pos

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