Biophysical Society 66th Annual Meeting Program Guide

441-Pos Board B265 SIMULTANEOUS RECORDING OF VOLTAGE SENSOR CHARGE MOVEMENT AND CALCIUM TRANSIENT IN RESPONSE TO A VOLTAGE CLAMP-INDUCED ACTION POTENTIAL WAVEFORM IN MOUSE SKELETAL MUSCLE FI - BERS. Hugo Bibollet , Erick O. Hernandez-Ochoa, Martin F. Schneider 442-Pos Board B266 MOLECULAR MECHANISMS OF DISEASE-CAUSING MUTATIONS IN THE FIRST VOLTAGE-SENSING DOMAIN OF CA V 1.1. Martin C. Heiss , Monica L. Fernandez-Quintero, Yousra El Ghaleb, Simone Pelizzari, Petronel Tuluc, Marta Campiglio, Klaus R. Liedl, Bernhard E. Flucher 443-Pos Board B267 MODULATION OF GLOBAL CA 2+ HANDLING BY SR-CA 2+ RELEASE DEPEND - ING ON IP3. Miguel Fernandez-Tenorio, Caroline Egger, Ruben Jose Lopez Dicuru, Joaquim Blanch, Marcel Egger 444-Pos Board B268 ALTERED CA 2+ CYCLING IN CARDIAC MYOCYTES LACKING NA + -DEPENDENT INACTIVATION OF NCX1. Kyle Scranton , Marina Angelini, Scott John, Rui Zhang, Joshua I. Goldhaber, Riccardo Olcese, Michela Ottolia 445-Pos Board B269 CHARACTERIZATION OF THE PLN-R14DEL MUTATION IN HIPSC-DERIVED CARDIOMYOCYTES. Beatrice Badone, Carlotta Ronchi, Francesco Lodola, Claudia Maniezzi, Daniele Martone, Anika E. Knaust, Arne Hansen, Thomas Eschenaghen, Antonio Zaza 446-Pos Board B270 CARDIOPROTECTION IN ISCHEMIA-REPERFUSION INJURY ACHIEVED BY A SINGLE AMINO ACID SUBSTITUTION OF NCX1 (H165A). Rui Zhang , Xiao - kang Wu, Catherine Xie, Devina Gonzalez, Raven Norris, Liang Li, Scott A. John, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber 447-Pos Board B271 STRUCTURAL CHARACTERIZATION OF MH/CCD NTD MUTATIONS IN SKELETAL RYANODINE RECEPTOR BY CRYO-EM. Kavita A. Iyer , Yifan Hu, Thomas Klose, Takashi Murayama, Montserrat Samso 448-Pos Board B272 CARDIAC ADAPTATIONS TO FREQUENT PREMATURE VENTRICULAR CON - TRACTIONS. JML Medina-Contreras, Jaime Balderas-Villalobos, Rafael J. Ramirez, Christopher Lynch, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit Voltage-Gated Na Channels (Boards B273 - B293) 449-Pos Board B273 VOLTAGE SENSITIVE ION CHANNELS: HARDWARE OR SOFT MATTER? CAN WE PARTICIPATE IN A DIALOGUE? H. Richard Leuchtag 450-Pos Board B274 QUANTUMMECHANICS, UNIVERSAL SCALING, AND FERROELECTRIC HYSTERESIS REGIMES IN THE GIANT SQUID AXON PROPAGATING ACTION POTENTIAL: A PHASE SPACE APPROACH. Nikola K. Jurisic , Fred Cooper 451-Pos Board B275 AUTOMATED PATCH-CLAMP WITH AUTOMATED ANALYSIS: EXTRACTING COMPOUND-SPECIFIC, CONCENTRATION-INDEPENDENT BIOPHYSICAL PROPERTIES OF INHIBITION FOR SODIUM CHANNEL INHIBITORS. Arpad Mike , Krisztina Pesti, Mátyás Csaba Földi, Adam Toth, Katalin Zboray, Peter Lukacs 452-Pos Board B276 CANNABIDIOL PROTECTS AGAINST LIPOPOLYSACCHARIDES-INDUCED INFLAMMATION IN CARDIAC SODIUM CHANNELS. Mohamed Fouda , Yasmine Fathy Mohamed, Ravichandra Venkateshappa, TomW. Claydon, Rachel Fernandez, Peter C. Ruben

453-Pos Board B277 CANNABIGEROL INHIBITS SODIUM CONDUCTANCE TO REDUCE NEURO - NAL DORSAL ROOT GANGLION EXCITABILITY. Mohammad-Reza Ghovan- loo , Mark Estacion, Peng Zhao, Sulayman Dib-Hajj, Stephen G. Waxman 454-Pos Board B278 HARNESSING AN ENDOGENOUS NA CHANNEL REGULATOR TO DEVISE POTENT INHIBITORS OF ARRHYTHMOGENIC LATE NA CURRENT. Nourdine Chakouri , Sharen Rivas, Johanna Diaz, Daniel Roybal, Lin Yang, Bi-xing Chen, Josiah O. owoyemi, Ivy E. Dick, Gordon F. Tomaselli, Steven O. Marx, Manu Ben-Johny 455-Pos Board B279 Travel Award Winner VASCULAR ENDOTHELIAL BARRIER PROTECTION PREVENTS NANOSCALE CARDIAC REMODELING: A NOVEL STRATEGY TO PREVENT ATRIAL FIBRIL - LATION. Louisa Mezache , AndrewM. Soltisz, Scott R. Johnstone, Brant Isakson, Rengasayee Veeraraghavan 456-Pos Board B280 ELUCIDATING STRUCTURAL ROLE OF DISEASE-ASSOCIATED MUTATIONS IN CARDIAC SODIUM CHANNEL NA V 1.5. Jing Li , Eslam Elhanafy 457-Pos Board B281 THE NAV1.5 ACCESSORY SUBUNIT FGF12A INHIBITS PRO-ARRHYTHMIC LATE SODIUM CURRENT. Paweorn Angsutararux , Martina Marras, Carlota Abella, Taylor L. Voelker, Catherine Malcolm, Jingyi Shi, Jeanne M. Nerbonne, Jonathan R. Silva 458-Pos Board B282 NA V 1.5 KNOCKOUT IN IPSCS: A NOVEL APPROACH TO STUDY NA V 1.5 VARIANTS IN A HUMAN CARDIOMYOCYTE ENVIRONMENT. Marion Pierre , Mohammed Djemai, Hugo Poulin, Mohamed Chahine 459-Pos Board B283 UNDERSTANDING THE MECHANISMS OF ARRHYTHMIA-LINKED VARIANTS IN THE DISORDERED REGIONS OF NAV1.5. Emily Wagner , Kiersten Ruff, Catherine Gooch, Jennifer Silva, Jonathan R. Silva 460-Pos Board B284 TRUNCATIONS OF NA V 1.5 CARBOXY-TERMINAL DOMAIN DIFFERENTIALLY PERTURB CHANNEL FUNCTION. Ryan W. Mahling , Nourdine Chakouri, Manu Ben-Johny 461-Pos Board B285 HIGH-THROUGHPUT FUNCTIONAL ANALYSIS OF HUMAN NA V 1.6 VARI - ANTS EXPRESSED IN ADULT AND NEONATAL ISOFORMS. Carlos G. Vanoye , Tatiana Abranova, Jean-Marc L. DeKeyser, Nora F. Ghabra, Chris - topher H. Thompson, Alfred L. George 462-Pos Board B286 HIGH-THROUGHPUT ELECTROPHYSIOLOGY REVEALS SUBTYPE SPECIFIC TEMPERATURE DEPENDENCE OF SODIUM CHANNEL ACTIVATION AND INACTIVATION. Sophia Kriegeskorte , Raya Bott, Martin Hampl, Ralf Haus - mann, Angelika Lampert 463-Pos Board B287 NA V 1.1 PLAYS A TEMPERATURE DEPENDENT ROLE IN PROPRIOCEPTOR EXCITABILITY. Cyrrus M. Espino , Cheyanne Lewis, Kaylee Wells, Darik O'Neil, Theanne Griffith 464-Pos Board B288 PROBING NONCANONICAL COUPLING BETWEEN VOLTAGE SENSOR DOMAINS AND PORE DOMAINS IN VOLTAGE-GATED SODIUM CHAN - NELS. Fraol Galan , Carlos Alberto Z. Bassetto Jr, Francisco Bezanilla 465-Pos Board B289 CHARGE IMMOBILIZATION IN TWO DIFFERENT FAST-INACTIVATION- REMOVED NAV1.4 SODIUM CHANNEL MUTANTS. . Yichen Liu , Francisco Bezanilla

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