Biophysical Society 66th Annual Meeting Program Guide

626-Pos Board B450 A GENERALIZED FRAMEWORK FOR THE IMAGE FORMATION MODEL AND DISENTANGLEMENT OF CTF PARAMETERS IN CRYO-ELECTRON MICROS - COPY. Geoffrey Woollard , Khanh Dao Duc 627-Pos Board B451 DEEP LEARNING-BASED LOCAL QUALITY ESTIMATION FOR PROTEIN STRUCTURE MODELS FROM CRYO-EMMAPS. Genki Terashi , Xiao Wang, Sai Raghavendra Maddhuri Venkata Subramaniya, John J. Tesmer, Daisuke Kihara 628-Pos Board B452 STRUCTURAL CHANGES OF PLASMODIUM FALCIPARUM DURING EARLY DEVELOpmENT IN THE HUMAN ERYTHROCYTE REVEALED BY CORRELA - TIVE LIVE-CELL IMAGING AND SERIAL SECTION ELECTRON MICROSCO - PY. Yuto Kegawa , Jennifer D. Petersen, Lila Gordon, Joshua Zimmerberg 629-Pos Board B453 LABORATORY FOR BIOMOLECULAR STRUCTURE (LBMS): A DOE-FUNDED NATIONAL CRYO-EM CENTER. Liguo Wang , Guobin Hu, Jake Kaminsky, Qun Liu, Sean McSweeney 630-Pos Board B454 ENERGY DISPERSIVE X-RAY SPECTROMETRY REVEALS AN UNEXPECTED VARIABILITY IN ELECTRON MICROSCOPY STAIN DISTRIBUTION WITHIN CELLS AND TISSUES. Louise C. Hughes , Errin Johnson 631-Pos Board B455 DEEP-LEARNING IN-SITU CLASSIFICATION OF HIV-1 VIRION MORPHOL - OGY. Juan S. Rey , Wen Li, Alexander J. Bryer, Hagan Beatson, Christian Lantz, Alan Engelman, Juan R. Perilla 632-Pos Board B456 EVALUATION OF HOLLOW-CONE ELECTRON IMAGING ON BIOMOL - ECULES. Po-Lin Chiu 633-Pos Board B457 IMPROVING MEMBRANE PROTEIN STRUCTURAL STUDY IN ELECTRON CRYO-MICROSCOPY: IMPACT OF SURFACTANT EXCESS. Baptiste Michon , Anniina Salonen, Emmanuelle Rio, Améile Leforestier, Jeril Degrouard, Manuela A. Zoonens 634-Pos Board B458 WAFFLE METHOD: AN APPROACH FOR CRYO-FIB/SEM THIN LAMELLAE PREPARATION. Daija Bobe , Mykhailo Kopylov, Alex Noble, Ashleigh M. Raczkowski, Oleg Klykov, Bridget Carragher, Clinton S. Potter 635-Pos Board B459 A LASER-BASED PHASE PLATE FOR CRYO-ELECTRON MICROSCOPY. Jeremy Axelrod , Jeske Dioquino, Petar Petrov, Jonathan Remis, Robert M. Glaeser, Holger Mueller 636-Pos Board B460 ALTERNATIVE PRESERVATION METHODS IN CRYO-EM TO OVERCOME CHALLENGING SPECIMENS. Behrouz Ghazi Esfahani , Scott M. Stagg, Ruizhi Peng, Elizabeth Stroupe 637-Pos Board B461 GENETICALLY ENCODED LABELS FOR CELLULAR CRYO-ELECTRON TO - MOGRAPHY. Herman K.H. Fung , Yuki Hayashi, Veijo T. Salo, Christoph W. Müller, Sara Cuylen, Julia Mahamid 638-Pos Board B462 EVALUATING THE ACCURACY OF CLASSIFYING HETEROGENEOUS SINGLE- PARTICLE CRYO-EM DATASETS. William R. Arnold

639-Pos Board B463 CRYO-EM OF BACTERIAL FLAGELLAR FILAMENTS WITH SCREW-LIKE SURFACES AND OUTER DOMAIN SHEATHS. Mark A. Kreutzberger , Richard Sobe, Amber B. Sauder, Sharanya Chatterjee, Fengbin Wang, Volker Kiessling, Vincent Conticello, Gad Frankel, Melissa Kendall, Birgit Scharf, Edward H. Egelman Computational Methods and Bioinformatics I (Boards B464 - B494) 640-Pos Board B464 A “SHALLOW-LEARNING” MODEL IDENTIFIES TARGET-SEQUENCE PREFER - ENCES FOR DNA FRAGMENTATION AND TAGGING BY NEXTERA™ (TN5) “TAGMENTASE”. Niharika Pandala, Massa Shoura, Andrew Fire, Stephen D. Levene 641-Pos Board B465 A MACHINE LEARNING MODEL TO PREDICT QUANTUM-ACCURATE ELEC - TRON DENSITIES FOR DNA: APPLICATIONS FOR X-RAY CRYSTAL STRUC - TURE REFINEMENT. Alex Lee , Joshua A. Rackers, William Bricker 642-Pos Board B466 PREDICTING PROTEIN-DNA BINDING MODES. Alberto Perez 643-Pos Board B467 THERMODYNAMICS-BASED MODELING REVEALS REGULATORY EFFECTS OF INDIRECT TRANSCRIPTION FACTOR-DNABINDING IN DROSOPHI - LA. Shounak G. Bhogale , Saurabh Sinha 644-Pos Board B468 MOLECULAR DYNAMIC SIMULATIONS AND CALIBRATION OF THE RNA- PPR INTERACTIONS. Zohreh Nowzari 645-Pos Board B469 EXPLORING THE SEQUENCE-STRUCTURE MAP: JOINT EMBEDDING OF PROTEIN SEQUENCE & STRUCTURE. Francisco A. McGee , Vincenzo Carnevale 646-Pos Board B470 QWIKMD 2.0: BRIDGING THE GAP BETWEEN SEQUENCE, STRUCTURE, AND PROTEIN FUNCTION. Diego E. Barreto Gomes , Priscila S. Gomes, Rafael C. Bernardi 647-Pos Board B471 COMPUTED CHEMICAL PROPERTIES FOR PREDICTING PROTEIN FUNC - TION. Suhasini Iyengar, Lakindu Pathira Kankanamge, Penny Beuning, Mary Jo Ondrechen 648-Pos Board B472 AN IMPROVED COMPUTATIONAL APPROACH TO PREDICT HIV PROTEIN FUNCTIONS. Benjamin R. Litterer , Kejue Jia, Robert L. Jernigan 649-Pos Board B473 RELATIVE FEATURE IMPORTANCE FOR PREDICTION OF PHENOTYPICAL DIFFERENCES BETWEEN PROTEIN VARIANTS. Daniel Kool 650-Pos Board B474 TOPOLOGICAL APPROACH FOR SEQUENCE-INDEPENDENT PROTEIN STRUCTURE ALIGNMENT. Wai Shing Tang , Lorin Crawford 651-Pos Board B475 RECONSTRUCTING ATOMISTIC STRUCTURES FROM RESIDUE-LEVEL PROTEIN STRUCTURE NETWORKS USING ARTIFICIAL NEURAL NET - WORKS. Gianmarc Grazioli , Vy Duong, Elizabeth Diessner, Rachel W. Martin, Carter T. Butts 652-Pos Board B476 DEVELOpmENT OF A DEEP-LEARNING MODEL FOR PREDICTING THE HYDRATION STRUCTURES AROUND PROTEINS. Kosuke Kawama , Yusaku Fukushima, Takashi Yoshidome, Mitsunori Ikeguchi, Masateru Ohta

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