Biophysical Society 66th Annual Meeting Program Guide

781-Plat 11:00 am COMBATTING MULTIDRUG-RESISTANCE WITH MEMBRANE-ACTIVE PEP - TIDES. Tyler S. Johnson , Charles M. Deber 782-Plat 11:15 am HOW DOES POLYMYXIN B1 ENTER THE OUTER MEMBRANE OF E. COLI? Dhanushka Weerakoon , Kamen Petrov, Syma Khalid 783-Plat 11:30 am REVISITING LIPID II BINDING BY TEIXOBACTIN OLIGOMERS USING MEMBRANE MD SIMULATIONS. Po-Chao Wen , Susan L. Rempe, Emad Tajkhorshid 784-Plat 11:45 am RIVALRY OF CHOLESTEROL AND ANTIMICROBIAL PEPTIDES AS SEEN BY MOLECULAR SIMULATIONS AND NMR SPECTROSCOPY. Fathima T. Doole , Chun Kit Chan, Ellen Streitwieser, Daipayan Sarkar, Andrey V. Struts, Abhishek Singharoy, Michael F. Brown 785-Plat 12:00 pm TOWARDS A MOLECULAR UNDERSTANDING OF THE MEMBRANE ALTER - ING PROPERTIES OF VISCOSIN, A CYCLIC LIPODEPSIPEPTIDE. Vic De Roo , Niels Geudens, Yentl Verleysen, Tzong-Hsien Lee, Annemieke Madder, Mibel Aguilar, José C. Martins 786 -Plat 12:15 pm INVESTIGATING THE EFFICACY OF MITOCHONDRIA-TARGETED THERA - PEUTICS IN BARTH SYNDROME MODELS. Emery L. Ng , Nicholas A. Eddy, Hazel H. Szeto, Nathan N. Alder 787 -Plat 12:30 pm A PH-RESPONSIVE TRANSMEMBRANE PEPTIDE ACTS AS AN INHIBITOR OF T CELL RECEPTOR ACTIVATION. Yujie Ye , Francisco N. Barrera Platform Microtubule Motors 10:45 am - 12:45 pm, South, Level Two, Room 212/213/214 Co-Chairs Shivani Yadav, Indian Institute of Science Education and Research, Pune, India Sozanne R. Solmaz, Binghamton University, USA 788 -Plat 10:45 am POLYMORPHIC INTERRUPTION OF MOLECULAR ALLOSTERIC PATHWAYS IN MITOTIC KINESIN-5: COMPARISON OF EXPERIMENT AND ALGO - RITHMIC PREDICTION. Micquel Downs , Heather E. Soileau, Jessica M. Richard, Rachel Ramos, Victoria Dauphin, Joseph Chaney, Edward Wojcik, Sunyoung Kim 789-Plat 11:00 am LIGHT CHAIN 2 IS A TCTEX-TYPE RELATED AXONEMAL DYNEIN LIGHT CHAIN THAT REGULATES THE UNIQUE FLAGELLAR BEATING IN TRYPANO - SOMA BRUCEI . Subash C. Godar , James Oristian, Valerie Hinsch, Joshua Alper 790-Plat 11:15 am DELINEATING THE ROLE OF THE K-LOOP IN THE KIF1A CHEMOMECHANI - CAL CYCLE. Taylor M. Zaniewski , William O. Hancock 791-Plat 11:30 am COIL-TO-HELIX TRANSITION AT THE NUP358-BICD2 INTERFACE ACTIVATES BICD2 FOR DYNEIN RECRUITMENT. James Gibson, Heying Cui, M. Yusuf Ali, Xiaoxin Zhao, Erik W. Debler, Jing Zhao, Kathleen M. Trybus, Sozanne R. Solmaz , Chunyu Wang 792-Plat 11:45 am SINGLE DEPOLYMERIZING AND TRANSPORT KINESINS STABILIZE MICRO - TUBULE ENDS. Alexandra Ciorîta, Michael Bugiel, swathi sudhakar, Erik Schäffer, Anita Jannasch

793-Plat 12:00 pm SIZING UP THE CHALLENGE: THE NUMBER OF ACTIVE DYNEIN TEAMS SCALES WITH ORGANELLE SIZE. Simon Wieland , Christina Steininger, David E. Gitschier, Marius M. Kaiser, Wolfgang Gross, Adam G. Hendricks, Holger Kress 794-Plat 12:15 pm FLAGELLA-LIKE BEATING OF MICROTUBULES RECONSTITUTED IN VITRO WITH DYNEIN AND PINNED FILAMENTS. Shivani A. Yadav , Chaitanya A. Athale 795-Plat 12:30 pm VESICLES DRIVEN BY KINESIN AND DYNEIN IN VITRO ENGAGE IN A TUG- OF-WAR WHICH CAN BE BIASED BY MAPS. Ashwin I. DSouza , Rahul Grover, Stefan Diez Platform Modeling of Biological Systems 10:45 am - 12:45 pm, South, Level Two, Room 215/216 Co-Chairs Sumaiya Iqbal, Broad Institute of MIT and Harvard, USA Isabella Graf, Yale University, USA 796-Plat 10:45 am PATTERN FORMATION ALONG THE CENTRAL DOGMA BY THE NUMBERS. Yasemin Kiriscioglu , Hernan G. Garcia 797-Plat 11:00 am THE KINETIC LANDSCAPE OF HUMAN TRANSCRIPTION FACTORS. Nicho - las Mamrak, Nader Alerasool, Mikko Taipale, Timothee Lionnet 798-Plat 11:15 am PHASE BEHAVIOR OF MULTICOMPONENT MIXTURES WITH STRUCTURED INTERACTIONS. Isabella R. Graf , Benjamin B. Machta 799-Plat 11:30 am DEEP-LEARNING-BASED ANALYSIS OF COMBINATORIAL SYNTHETIC T-CELL RECEPTOR LIBRARIES. Shangying Wang , Kyle G. Daniels, Sara Capponi, Wendell Lim, Simone Bianco 800 -Plat 11:45 am ACCELERATING SINGLE PARTICLE DISCOVERIES USING MACHINE LEARN - ING. Jacob Kæstel-Hansen , Søren S.-. Bohr, Frank Høgh Schulz, Annette Juma Nielsen, Wouter Krogh Boomsma, Nikos S. Hatzakis 801-Plat 12:00 pm LARGE-SCALE SIMULATION OF TUMOR SPHEROID INVASION DYNAMICS. Eric Behle , Julian Herold, Jakob Rosenbauer, Alexander H. Schug 802-Plat 12:15 pm OPTIMAL CHECKPOINT STRATEGIES BALANCING RISK AND SPEED. Ahmad Sadeghi, Roxane Dervey, Vojislav Gligorovski, Sahand Rahi 803-Plat 12:30 pm GENOMIC ANALYSIS OF ALPHAFOLD2-PREDICTED STRUCTURES IDEN - TIFIES MAPS OF 3D ESSENTIAL SITES IN 243 NEURODEVELOpmENTAL DISORDER-ASSOCIATED PROTEINS. Sumaiya Iqbal , Tobias Brünger, Edu - ardo Pérez-Palma, David Hoksza, Arthur J. Campbell, Mark J. Daly, Patrick May, Dennis Lal

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