Biophysical Society 66th Annual Meeting Program Guide

Platform Ion Channels - Pharmacology and Disease 4:00 pm - 6:00 pm, South, Level Two, Room 215/216 Co-Chairs Steve Cannon, University of California, Los Angeles, USA Navin Verma, Lee Kong Chian School of Medicine, Singapore 851-Plat 4:00 pm MOLECULAR MECHANISMS UNDERLYING ENHANCED HEMICHANNEL FUNCTION OF A CATARACT-ASSOCIATED CX50 MUTANT. Lisa Ebihara , Jun-Jie Tong, Umair Khan, Bassam G. Haddad, Peter J. Minogue, Eric R. Beyerle, Eric C. Beyer, Viviana M. Berthoud, Steve L. Reichow 852-Plat 4:15 pm Travel Award Winner TMEM16A CHANNEL IS A KEY REGULATOR OF CEREBRAL BLOOD FLOW AT THE CAPILLARY LEVEL. Zeki Ilkan , Nils Korte, Claire Pearson, Thomas Pfeiffer, Prabhav Singhal, David Attwell, Paolo Tammaro 853-Plat 4:30 pm THERMODYNAMIC AND STRUCTURAL BASES FOR YODA1-MEDIATED PIEZO1 ACTIVATION. Tharaka D. Wijerathne , Alper D. Ozkan, Jerome J. Lacroix 854-Plat 4:45 pm Travel Award Winner A NEW K CA 3.1 CHANNEL ACTIVATOR SKA-346 BOOSTS T-CELL ANTITUMOR RESPONSE IN THE IMMUNE SUPPRESSIVE MICROENVIRONMENT. Navin K. Verma , Brandon Han Siang Wong, Seow Theng Ong, Stephanie Shee Min Goay, Ying Swan Ho, Shuwen Chen, Xuezhi Bi, Heesung Shim, Heike Wulff, K George Chandy 855-Plat 5:00 pm STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A HUMAN PO - TASSIUM CHANNEL, KIR2.1. Dania Zuniga , Carlos A. Henrique Fernandes, Charline Fagnen, Alexandre Pozza, Tahar Bouceba, Françoise Bonneté, Said Bendahhou, Renaud Wagner, Catherine Vénien-Bryan 856-Plat 5:15 pm MULTI-SCALE MODELING OF STATE-DEPENDENT DRUG BINDING TO THE HERG CHANNEL. Khoa Ngo , Kyle C. Rouen, John R.D. Dawson, Aiyana M. Emigh Cortez, Diego Lopez Mateos, Jan Maly, Kevin DeMarco, Vladimir Yarov-Yarovoy, Igor Vorobyov, Colleen E. Clancy 857-Plat 5:30 pm SUPPRESSOR TRNA-MEDIATED RESCUE OF HERG LQTS2 NONSENSE MUTATIONS. Viggo G. Blomquist, Jacqueline Niu , Henry M. Colecraft, Christopher A. Ahern 858-Plat 5:45 pm FUNCTIONAL RESCUE OF PERIODIC PARALYSIS BY IN VIVO GENE EDITING OF CAV1.1. Fen Fen Wu, Marbella Quinonez, Steve C. Cannon Speed Networking 4:30 pm - 6:00 pm, South, Exhibition Level Career development and networking is important in science, but can be a big time commitment. Here we offer refreshments and the chance to speed network, an exciting way to connect with a large number of biophysicists (including Biophysical Society committee members) in a short amount of time. Mid-career and more experienced scientists could learn how to get more involved in the Society or network for open posi - tions in their labs. Early career scientists could discuss career goals and challenges, get advice on tenure or grant writing, or find out how to gain recognition for their work. Graduate students and postdocs could make contacts to find their next position. After introductions, each person will have short 3 - 5 minute meetings with consecutive new contacts. During this time, you can exchange information and ask questions. When

841-Plat 5:30 pm COLLOIDAL AND ELECTROSTATIC INTERACTIONS IN FREE-STANDING MEMBRANES. Paige Liu, Oscar Zabala-Ferrera, Peter J. Beltramo 842-Plat 5:45 pm EFFECT OF POLYMERIC VISCOELASTIC ENVIRONMENT ON MULTISCALE STRUCTURAL DYNAMICS OF LIPID BILAYERS. Selcan Karaz, Erkan Senses Platform Calcium Signaling 4:00 pm - 6:00 pm, South, Level Two, Room 212/213/214 Co-Chairs Robyn Rebbeck, University of Minnesota, USA Erkan Karakas, Vanderbilt University, USA 843-Plat 4:00 pm NITROSYLATION OF CARDIAC CAMKII AT CYS290 MEDIATES MECHANICAL- AFTERLOAD INDUCED INCREASE IN CA TRANSIENTS. Chidera C. Alim , Christopher Y. Ko, Juliana Mira Hernandez, Erin Y. Shen, Sonya Baidar, Ye Chen-Izu, Julie Bossuyt, Donald M. Bers 844-Plat 4:15 pm CALCIUM SIGNALING AT THE NANOSCALE: DIADIC REMODELING IN HEART FAILURE WITH PRESERVED EJECTION FRACTION. Aaron D. Kaplan , Christopher W. Ward, W. Jonathan Lederer, Maura Greiser 845-Plat 4:30 pm Travel Award Winner FRET ASSAYS FOR RYR-TARGETED DRUG DISCOVERY PLATFORMS. Robyn T. Rebbeck , Kaja Berg, Gabrielle M. Evans, Jacob Schwarz, Jake R. Trask, Lindsey M. McGurran, Courtney C. Aldrich, Donald M. Bers, David D. Thomas, Razvan L. Cornea 846-Plat 4:45 pm MOLECULAR MECHANISMS OF THE MITOCHONDRIAL CALCIUM UNI - PORTER PART II: EVIDENCE AGAINST MICU1 AS A UNIPORTER POTENTIA - TOR. Anna Van Keuren 847-Plat 5:00 pm STRUCTURAL BASIS FOR ACTIVATION AND GATING OF IPRECEPTOR CAL - CIUM CHANNELS. Emily A. Schmitz, Hirohide Takahashi, Erkan Karakas 848-Plat 5:15 pm SK CHANNEL ENHANCEMENT REDUCES ARRHYTHMOGENESIS IN HEREDI - TARY ARRHYTHMIA SYNDROME MODEL WITH RYR2 COMPLEX GAIN-OF- FUNCTION. Roland Veress , Fruzsina Perger, Zuzana Nichtova, Radmila Terentyeva, Benjamin Martin, Shanna Hamilton, Bjorn C. Knollmann, Sandor Gyorke, Gyorgy Csordas, Dmitry A. Terentyev 849-Plat 5:30 pm DIFFERENTIAL IMPACTS OF ARRHYTHMIA-LINKED LOSS-OF-FUNCTION RYR2 MUTATIONS ON CA 2+ SIGNALING IN CARDIAC CELLS. Nagomi Kurebayashi , Takashi Murayama, Naoyuki Tetsuo, Sayako Hirose, Minoru Horie, Seiko Ohno, Takashi Sakurai 850-Plat 5:45 pm CRYO-EM STUDIES OF RYANODINE RECEPTOR DISEASE MUTANT AND MODULATION BY CALMODULIN. Yu S. Chen , Kellie A. Woll, Omid Haji- Ghassemi, Filip Van Petegem

M O N D A Y

68