Biophysical Society 66th Annual Meeting Program Guide

In this presentation, current collaborators and customers from the US and Europe will be featuring our latest products through their own expe - riences, ranging from nanopore and nanopipettes experiments at high bandwidth. Also, you will learn how to measure translocations through nanopores of environmental samples and the application of nanopipettes

time is up, you select the next person to talk to. By the end of the event, each participant will have had meaningful interactions with over half a dozen colleagues and the opportunity to meet many more. It's that simple! Space is limited for this event.We recommend arriving early to secure a seat as space is limited. Exhibitor Presentation Interherence GmbH 4:30 pm - 6:00 pm, Esplanade, Room 158 Reproducibility Through Precision: Chip-Based Technologies For Precise Control of Sample Temperature and Illumination in High- and Superresolution Microscopy Biological systems are complex and many environmental parameters affect their behavior. The chemical conditions of the sample volume, including pH and salt concentration, are often well considered when designing experiments in high and super-resolution microscopy. However, control over the physical conditions such as temperature or the am ount of light deposited in the sample volume are often not well characterized and might differ from setup to setup. The imprecisions mainly arise due to the lack of appropriate sensor that can be placed close to or directly in the sample volume. Integrated systems, which are in direct contact with the sample, can help to improve reproducibility in biophysical studies of living cells, proteins or DNA and make interpretation of the acquired data easier. Measuring and controlling the temperature of small sample volumes, as is often the case in high and super resolution microscopy, is technological challenging. In the first part of this talk, we will review state of the art ap - proaches for temperature management in light microscopy, analyze their strengths and weaknesses and talk about our solution, VAHEAT. We will highlight the importance of controlling the temperature in biophysical studies based on recent research covering the fields of single molecules studies, live cell imaging and colloid chemistry. In the second part of the talk, we will focus on illumination conditions specifically in total internal reflection (TIR) microscopy. After analyzing the limits of current technologies, we take the opportunity to pre-launch QuScite - our device for TIRF microscopy on a chip. This waveguide TIR system relies on photonic integrated circuitry (PIC) and allows to separate the excitation from detection path, which opens up completely new pathways for studying single molecules and processes in cell membranes. QuScite’s unprecedented field of view in the range of square millimeters combined with its ease of use even in complex workflows should allow everyone, on any microscope to perform high sensitivity TIRF measure - ments under reproducible conditions. Note: This presentation will be interactive. You will have the opportunity to see and test demo systems on site. Speakers Jaroslav Icha, CMO, Interherence GmbH Pierre Türschmann, CEO, Interherence GmbH Exhibitor Presentation Elements srl 5:30 pm - 7:00 pm, Esplanade, Room 157 The World’s First Commercial 10 MHz Bandwidth and Low-Noise Ampli- fier For Nanopore Applications Ultra-portable and cost-effective amplifier technology is now a reality, accessible to any research laboratory thanks to Elements miniaturized products based on custom CMOS microchips. Our flagship products are the eNPR, a handheld nanopore kit for nanoparticle detection using dis - posable glass nanopore chips and the new 10 MHz bandwidth amplifier for nanopore applications. The 10 MHz amplifier can boast an excep - tional low-noise on the whole spectrum up to 10 MHz, a stunning time resolution of 25 ns without nanopore chips and excellent EMI shielding thanks to the integrated faraday cage.

M O N D A Y

in analytical science. Presentation agenda: •

Company overview, Federico Thei

• “The NASA project sequel, is there life on other bodies of our solar system? Detecting life in Ocean Worlds with low-capacitance solid- state nanopores”, David Niedzwiecki • 10 MHz Bandwidth amplifier product launch, Federico Thei • “Preliminary results and comparison to previous translocation data at 10 MHz”, David Niedzwiecki, Marija Drndić • “Nanopipettes high bandwidth experiments”, Samuel Confederat About Elements: Elements provides versatile solutions to measure electric currents in the picoampere (10-12 pA) range, with bandwidths up to hundreds of kHz, featuring very low noise recordings, signal digitization thanks to the integrated Analog-to-Digital converter, signal generator, digital data elaboration, and USB powered, all in a tiny form factor, about the size of a point-and-shoot digital camera! Complimentary Italian hors d’oeuvres and drinks will be served! Seating Federico Thei, CEO Elements srl David Niedzwiecki, Goeppert LLC Marija Drndić, Professors of Physics, University of Pennsylvania Samuel Confederat, University of Leeds Dinner Meet-Ups 6:00 pm - 6:30 pm, South Lobby/Society Booth Interested in making new acquaintances and experiencing the cuisine of San Francisco? Meet at the Society Booth each evening Sunday through Tuesday at 6:00 pm, where a BPS member will coordinate dinner at a local restaurant. Awards and 2022 Biophysical Society Lecture 8:00 pm - 9:15 pm, North, Lower Lobby, Room 24/25 PRESENTATION OF AWARDS 8:00 pm 859-BPSL 8:30 pm INNOVATION BY EVOLUTION: BRINGING NEW CHEMISTRY TO LIFE. Frances H. Arnold Reception and Dance 9:30 pm - 12:00 am, South, Exhibition Level, Hall D (CANCELLED FOR 2022) Reception and Quiet Room 9:30 pm - 12:00 am, South, Exhibition Level, Room 1/2 (CANCELLED FOR 2022) is limited! Speakers

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