Biophysical Society 67th Annual Meeting Program Guide

1232-pos Board B361 FURTHER CHARACTERIZATION OF TWO OPPOSITELY-ACTING, EPILEPSY ASSOCIATED MUTATIONS AT POSITION H310 OF K V 1.2 ( KCNA2 ) CHAN NELS. Varsha Prakash , Teresa Minguez Vinas, Kaiqian Wang, Sarah H. Lindström, Cecilia Gunnarsson, Antonios Pantazis 1233-pos Board B362 Travel Award Winner FROM SIMULATION TO APPLICATION: ELUCIDATING PROTOXIN-2 BIND ING MECHANISM IN PAIN CHANNEL NA V 1.7 THROUGH DYNAMICS SIMU LATION AND BIOPHYSICS. Joekeem D. Arizala , Abba Leffler, Sebastien F. Poget 1234-pos Board B363 HOTSPOTS DETECTION AND DISTRIBUTION PATTERN OF DISEASE-ASSOCI ATED MUTATIONS IN VOLTAGE-GATED SODIUM CHANNELS. Amin Akbari Ahangar , Jing Li 1235-pos Board B364 INHERITED DISEASE-LINKED ARGININE76 OR EQUIVALENT RESIDUE MUTANTS IN CX50 AND CX45 SHOWED IMPAIRED HOMOTYPIC AND HETEROTYPIC GAP JUNCTION FUNCTION, BUT NOT CX43. Tianhe Li, Hon ghong Chen, Xiaole Li, Peter B. Stathopulos, Donglin Bai 1236-pos Board B365 LYSOSOMAL CA 2+ -FLUX CONTRIBUTES TO ABNORMAL AUTOMATICITY RELATED ARRHYTHMIA IN VENTRICULAR CARDIOMYOPATHY. An Xie , Gyeoung-Jin Kang, Eun Ji Kim, Feng Feng, Samuel C. Dudley 1237-pos Board B366 PHYSIOLOGICAL ROLE OF SK CHANNELS IN MODULATING CARDIAC RE POLARIZATION: APD AND DISPERSION AT SLOW HEART RATE IN LONG QT SYNDROME. Peter Bronk , Tae Yun Kim, Yi Chun Lu, Nilufer Turan, Zhilin Qu, Radmila Terentyeva, Dmitry A. Terentyev, Gideon Koren, Bum-Rak Choi 1238-pos Board B367 IQM-22110, A NEW SELECTIVE INHIBITOR OF KCHIP3 AND ITS ELECTRO PHYSIOLOGICAL EFFECTS ON K V 4.3, K V 4.3/KCHIP3 AND K V 4.3/KCHIP2 CURRENTS. Paula G. Socuéllamos , Angela de Benito-Bueno, Maria Ropero, Sara Diez, Pablo Elizalde, M Angeles Bonache, Carmen Viedma, Mercedes Martín-Martínez, Marta Gutiérrez-Rodríguez, Carmen Valen zuela 1239-pos Board B368 SUBTYPE-SPECIFIC BLOCK OF GLIOBLASTOMA MOTILITY THROUGH DUAL INHIBITION OF WATER AND ION FLUX. Alanah Varricchio , Andrea J. Yool, Sunita A. Ramesh 1240-pos Board B369 INVESTIGATING THE IMPACT AND THE ACTION MECHANISM OF KCA3.1 BLOCKERS ON A METASTATIC MELANOMA CELL LINE. Paolo Zuccolini , Raffaella Barbieri, Francesca Sbrana, Cristiana Picco, Paola Gavazzo, Michael Pusch 1241-pos Board B370 PHOTOPHARMACOLOGICAL DISSOCIATION OF TRANSCRIPTIONAL ACTI VATION AND DEGRANULATION OF MAST CELLS. Denis Krivic , Bernadett Bacsa, Kathrin S. Maitz, Annarita Graziani, Julia Kargl, Klaus Groschner 1242-pos Board B371 AUGMENTING THE ACTIVITY OF CALCIUM-ACTIVATED POTASSIUM CHANNEL K CA 3.1 REVITALIZES T-CELL FUNCTION IN THE IMMUNOSUP PRESSIVE TUMOR MICROENVIRONMENT. Navin K. Verma , Brandon Han Siang Wong, Seow Theng Ong, Stephanie Shee Min Goay, Ying Swan Ho, Shuwen Chen, Xuezhi Bi, Heesung Shim, Heike Wulff, Richard D. Webster, Vishalkumar G. Shelat, K George Chandy 1243-pos Board B372 IDENTIFICATION OF A NEW FAMILY OF INHIBITORS OF THE HUMAN HV1 PROTON CHANNEL. Adam Feher, Eva Korpos-Pintye-Gyuri, Martina Piga, Tihomir Tomasic, Nace Zidar, Adrienn Gyongyosi, Judit Kallai, Arpad Lanyi, Ferenc Papp, Katinka Gyuris, Zoltan Varga

1220-pos Travel Award Winner TWO GATES MEDIATE NMDAR ACTIVITY AND ARE UNDER SUBUNIT SPECIFIC REGULATION. Miaomiao He , Johansen Amin, Ramesh Prasad, Xiaoling Leng, Huan-Xiang Zhou, Lonnie P. Wollmuth 1221-pos Board B350 FUNCTIONAL ROLE OF CONSERVED AMINO ACID RESIDUES IN THE INTRACELLULAR DOMAIN OF Α7 ACETYLCHOLINE RECEPTORS. Irina Kim Cavdar , Hoa Quynh Do, Nermina Sarayli Belirgen, Lauretta Anne Pierre, Michaela Jansen Ion Channels, Pharmacology, and Disease I (Boards B351 - B380) 1222-pos Board B351 PATCH CLAMP STUDY OF BENZYDAMINE EFFECT OVER NEURONAL EXCIT ABILITY ON INFLAMMATION SENSITIZED RAT NOCICEPTORS. Antonio V. Ferrer-Montiel , Magdalena Nikolaeva-Koleva, Ana Espinosa, Matteo Vergassola, Lorenzo Polenzani, Lorella Ragni, Sara Zucchi, Isabel Devesa 1223-pos Board B352 MAPPING THE BINDING SITE OF NS309, A SUPERAGONISTIC POSITIVE GATING MODULATOR FOR THE CALCIUM-ACTIVATED POTASSIUM CHAN NEL KCA3.1. Joshua A. Nasburg 1224-pos Board B353 STRUCTURE-FUNCTION STUDIES OF LOSS-OF-FUNCTION K CA 2.2 MUTANT CHANNELS. Mohammad Asikur Rahman , Young Woo Nam, Grace Yang, Myles D. Myles, Razan Orfali, Meng Cui, Miao Zhang 1225-pos Board B354 NOVEL MECHANISM OF EAG CHANNEL INHIBITION BY IMIPRAMINE. Ze-Jun Wang , Xi Chen, Tinatin I. Brelidze 1226-pos Board B355 MOLECULAR SIMULATIONS OF STATE-SPECIFIC DRUG INTERACTIONS WITH MULTIPLE CARDIAC ION CHANNELS TO REVEAL MECHANISMS OF ARRHYTHMOGENESIS. Kyle C. Rouen , Khoa Ngo, Abhishek A. Kognole, Himanshu Goel, Asuka Orr, Anmol Kumar, Aiyana Emigh Cortez, Jan Maly, Vladimir Yarov-Yarovoy, Alexander D. MacKerell, Igor Vorobyov 1227-pos Board B356 COMPARISON OF EFFICACY AND FUNCTIONAL CONSEQUENCES OF SIRNA AND CRISPRI GENE MODULATION WITH DIFFERENT EFFECTOR DOMAINS IN POST-DIFFERENTIATED HUMAN IPSC-CMS. Julie Han , Yuli W. Heinson, Emilia Entcheva 1228-pos Board B357 THE ENDOCANNABINOID ARA-S DISPLAYS VARIABLY ACTIVATING EFFECTS ON K V 7.1/KCNE1 CARRYING LONG QT SYNDROME MUTATIONS. Irene Hiniesto Iñigo , Siri A. Lundholm, Sara I. Liin 1229-pos Board B358 VOLTAGE SENSOR TARGETED ACTIVATION OF KV7 CHANNELS BY QO 58. Richard Kanyo 1230-pos Board B359 HUMAN INDUCE PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES TO STUDY PUFA ANALOGUES AS A POTENTIAL TREATMENT OF LONG QT SYNDROME. Alicia de la Cruz , Derek M. Dykxhoorn, Rene Barro-Soria, Ashutosh Agarwal, Peter H. Larsson 1231-pos Board B360 CHRONIC ANGIOTENSIN II SIGNALING DRIVES SUSTAINED PIP 2 DEFICITS AND ALTERED SARCOLEMMAL CA V 1.2 EXPRESSION AND FUNCTION IN CARDIOMYOCYTES. Taylor L. Voelker , Silvia G. del Villar, Maartje F. Westhoff, Eamonn J. Dickson, Rose E. Dixon Board B349

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