Biophysical Society 67th Annual Meeting Program Guide

1256-pos Board B385 CONFORMATIONAL AND ENERGETIC BASIS OF ACTOMYOSIN FORCE GENERATION. Wen Ma , Shengjun You, Michael Regnier, James A. Mc Cammon 1257-pos Board B386 A POINT MUTATION IN SWITCH 1 ALTERS THE LOAD DEPENDENCE OF PHOSPHATE REBINDING TO ACTOMYOSIN. Christopher Marang , Brent Scott, James Chambers, Laura K. Gunther, Christopher M. Yengo, Edward P. Debold 1258-pos Board B387 MECHANISTIC INSIGHTS INTO THE REGULATION OF HUMAN MYOSIN 7A. Alexandra Hollo , Neil Billington, Yasuharu Takagi, Andras Kengyel, James R. Sellers, Rong Liu 1259-pos Board B388 SOLUTION KINETICS ANALYSIS OF VESICLE TRAFFICKING OF ZYMOGEN GRANULE. Susheel Pangeni , Justin Raupp, Takeshi Sakamoto 1260-pos Board B389 CRYO-EM STRUCTURE OF THE FLIGHT MUSCLE THICK FILAMENT FROM THE BUMBLE BEE, BOMBUS IGNITUS WITH NOVEL NON-MYOSIN DENSI TIES REVEALED. Jiawei Li 1261-pos Board B390 SMALL MOLECULES MODULATING FORCE PRODUCTION: A NEW PERSPECTIVE AGAINST MYOSIN-ASSOCIATED DISEASES. Daniel Auguin, Dihia Moussaoui, James P. Robblee, Carlos Kikuti, Maria Elena Sirkia, Louise Canon, Julien Robert-Paganin, Kathleen M. Trybus, Anne M. Board B391 MOTILE PROPERTIES OF NONMUSCLE MYOSIN 2C. Mohammad Ashikur Rahman , James R. Sellers Cytoskeletal Assemblies and Dynamics (Boards B392 - B407) 1263-pos Board B392 ELUCIDATING THE MOLECULAR DETERMINANTS OF FORCE TRANSMIS SION IN MYOSIN ENSEMBLES USING QCM-D. Emily M. Kerivan , Lydia Robbins, Mallory Moffett, Henry Seiler, Dana N. Reinemann 1264-pos Board B393 DISSECTING ACTIN-MICROTUBULE CROSSTALK WITH A NOVEL MULTI FILAMENT OPTICAL TRAPPING ASSAY. Lyle Tobin , Dana N. Reinemann 1265-pos Board B394 MICROSCALE MECHANICS OF ACTIN-VIMENTIN COMPOSITE NET WORKS. Bekele J. Gurmessa 1266-pos Board B395 CKAP5 ENABLES SEEDING OF ACTIN BUNDLES BY EXPLORATORY MICRO TUBULES. Jan Sabo , Michaela Zdimalova, Marcus Braun, Zdenek Lansky 1267-pos Board B396 CLASP2 FACILITATES DYNAMIC ACTIN FILAMENT ORGANIZATION ALONG THE MICROTUBULE LATTICE. Nicole C. Rodgers , Elizabeth J. Lawrence, Avishkar V. Sawant, Nadia Efimova, Gabriela Gonzalez-Vasquez, Tara T. Hickman, Irina Kaverina, Marija Zanic 1268-pos Board B397 KINESIN DRIVEN ACTIVE CYTOSKELETAL COMPOSITE RESTRUCTUR ING. Maya Hendija , Rae Robertson-Anderson, Daisy H. Achiriloaie, Jennifer L. Ross Houdusse 1262-pos

1244-pos Board B373 ROLE OF H V 1 CHANNEL IN CANCER IMMUNOPROTECTION AND MALIG NANCY. Christian A. Carrillo-Soto , Juan J. Alvear, Antonio Peña-Pichicoi, Miguel Fernandez, Emerson M. Carmona, Jose A. Garate, Carlos L. Board B374 PHARMACOLOGICAL MODULATION OF TREK1 CHANNEL. Edward Francisco Mendez Otalvaro , Wojciech Kopec, Bert L. de Groot 1246-pos Board B375 A NOVEL KIR-SPECIFIC KATP CHANNEL OPENER. Ivan Gando , Manuel Becerra-Flores, I-Shan Chen, Hua-Qian Yang, Show-Ling Shyng, Tomoe Y. Nakamura, Timothy J. Cardozo, William A. Coetzee 1247-pos Board B376 THALLIUM FLUX ASSAY ADAPTATION FOR MULTI-INSTRUMENT COM PATIBILITY. Derek S. Hernandez , C. D. Weaver 1248-pos Board B377 A SELECTIVITY FILTER MUTATION PROVIDES INSIGHTS INTO GATING REGULATION OF A K + CHANNEL. Theres Friesacher , Haritha P. Reddy, Harald Bernsteiner, J Carlo Combista, Boris Shalomov, Amal K. Bera, Eva Maria Plessl, Nathan Dascal, Anna Stary-Weinzinger 1249-pos Board B378 ETHOSUXIMIDE IS AN ALLOSTERIC BLOCKER OF GIRK CHANNELS WITH GΒΓ AND IS SUBUNIT DEPENDENT. Boris Shalomov , J. Carlo Combista, Haritha P. Reddy, Shoham Dabbah, Daniel Yakubovich, Nathan Dascal 1250-pos Board B379 Travel Award Winner MONTELUKAST ACTIVATES BK CHANNELS ASSOCIATED WITH THE Β4 ACCESSORY SUBUNIT AND EMERGES AS A PHARMACOLOGICAL TOOL TO REDUCE HIPPOCAMPAL EXCITABILITY. Federico Orsi, Juliana Monat, Veronica Milesi, Jesica Raingo, Pedro Martín 1251-pos Board B380 CHOLESTEROL BINDING TO BK CHANNEL-FORMING PROTEINS IN VOLVES THE CENTRAL TYROSINE OF A CRAC DOMAIN LOCATED AT THE CHANNEL CORE-CYTOSOLIC TAIL INTERFACE. Elizabeth H. Schneider , Alexandria V. Slayden, Sydney M. Hawks, Steven C. Mysiewicz, Kelsey C. North, Alex M. Dopico, Anna N. Bukiya Poster: Myosins (Boards B381 - B391) 1252-pos Board B381 MOLECULAR CHARACTERIZATION OF A NOVEL MYH7 MUTATION Q222H IN A PATIENT WITH SEVERE DILATED CARDIOMYOPATHY. Masataka Kawana , Rama Reddy Goluguri, Aminah Dawood, James A. Spudich, Kathleen Ruppel 1253-pos Board B382 CRYO-EM STRUCTURE OF THE FOLDED-BACK STATE OF HUMAN Β-CARDIAC MYOSIN. Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, eaazhisai Kandiah, Kathleen Ruppel, James A. Spudich, Anne M. Houdusse, Julien Robert Paganin 1254-pos Board B383 DILATED CARDIOMYOPATHY MUTATION (E525K) IN HUMAN BETA-CAR DIAC MYOSIN ENHANCES ACTIN-ACTIVATED PHOSPHATE RELEASE BUT STABILIZES THE AUTO-INHIBITED SUPER-RELAXED STATE. Skylar M.L. Bodt , David V. Rasicci, Rohini Desetty, Christopher M. Yengo 1255-pos Board B384 EXPLORING THE EFFECT OF MYOSIN MODULATORS ON THE ATP HYDRO LYSIS STEP OF HUMAN CARDIAC BETA MYOSIN USING TRANSITION PATH SAMPLING. Ananya Chakraborti , Jil C. Tardiff, Steven D. Schwartz Gonzalez 1245-pos

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