Biophysical Society 67th Annual Meeting Program Guide

Platform Calcium Handling and Electrophysiology I 4:00 pm - 6:00 pm, Room 5AB Co-Chairs Chen-Wei Tsai, University of Colorado Denver, USA Rengasayee Veeraraghavan, The Ohio State University, USA 165-plat 4:00 pm RECONSTITUTION OF DEPOLARIZATION-INDUCED CA 2+ RELEASE FOR VALIDATION OF SKELETAL MUSCLE DISEASE MUTATIONS AND DRUG DIS COVERY. Takashi Murayama , Nagomi Kurebayashi, Takuro Numaga-To mita, Takuya Kobayashi, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, Mitsuhiko Yamada, Takashi Sakurai 166-plat 4:15 pm ELEVATED CA 2+ AT THE TRIAD JUNCTION UNDERLIES DYSREGULATION OF CA 2+ SIGNALING IN DYSFERLINOPATHY. Valeriy I. Lukyanenko , Joaquin M. Muriel, Robert J. Bloch 167-plat 4:30 pm QUANTITATIVE MALE-TO-FEMALE TRANSLATION OF CARDIAC ELEC TROPHYSIOLOGICAL RESPONSE TO DRUGS. Kim T. Hellgren , Haibo Ni, Stefano Morotti, Eleonora Grandi 168-plat 4:45 pm Travel Award Winner MOLECULAR AND CELLULAR MECHANISMS UNDERLYING TISSUE-SPECIF IC MICU-DIMER ASSEMBLY IN THE MITOCHONDRIAL CALCIUM UNIPORT ER COMPLEX. Chen-Wei Tsai , Madison Rodriguez, Ming-Feng Tsai 5:00 pm Flash Talks 169-plat 5:15 pm EMPAGLIFLOZIN AND ROS-CAMKII-LATE SODIUM CURRENT SIGNALING IN HEART FAILURE WITH PRESERVED EJECTION FRACTION. Bence Hegyi , Juliana Mira Hernandez, Erin Y. Shen, Emily R. Spencer, Daria Smoliarchuk, Tory A. Edwards, Christopher Y. Ko, Julie Bossuyt, Donald M. Bers 170-plat 5:30 pm A SYSTEMATIC INVESTIGATION OF THE CARDIAC INTERCALATED DISK IN HEALTH AND DISEASE. Heather Struckman , Nicolae Moise, Ryan King, AndrewM. Soltisz, Andrew Buxton, Izabella Dunlap, Zhenhui Chen, Prze myslaw Radwanski, Seth H. Weinberg, Rengasayee Veeraraghavan 171-plat 5:45 pm Travel Award Winner ACTION POTENTIAL HETEROGENEITY IN THE MYOSIN BINDING PROTEIN C3 MUTANT, R943X. Mena Abdelsayed , Mark Mercola Platform

174-plat 4:30 pm FROM INTEGRATIVE ATOMIC-RESOLUTION ENSEMBLES OF DISORDERED PROTEINS TO SIMULATIONS OF PHASE-SEPARATED CONDENSATES. Lukas S. Stelzl , Lisa M. Pietrek, Xiaofei Ping, Andrea Holla, Mateusz Sikora, Juer gen Koefinger, Dorothee Dormann, Benjamin Schuler, Markus Zweckstet ter, Gerhard Hummer 175-plat 4:45 pm AN INTEGRATIVE APPROACH TO MOLECULAR DYNAMICS AND SINGLE MOLECULE FRET TECHNIQUES. Mahmoud Moradi , Maolin Lu, Reza Vafabakhsh, Colin D. Heyes 176-plat 5:00 pm IMPROVED POLARIZABLE FORCE FIELD FOR MODELING MG 2+ BINDING TO PROTEINS AND NUCLEOTIDES. Julian A. Melendez , Peter R. Nagy, Sameer Varma 177-plat 5:15 pm PROBING ENDOPHILIN-MEDIATED ENDOCYTOSIS VIA MOLECULAR DYNAMICS SIMULATIONS. Jeriann Beiter , Patricia M. Bassereau, Gregory A. Voth 178-plat 5:30 pm INDUCING CONCENTRATION GRADIENTS ACROSS THE MEMBRANE IN MOLECULAR DYNAMICS SIMULATIONS TO INVESTIGATE MEMBRANE PERMEABILITY. Eric Shinn , Emad Tajkhorshid 179-plat 5:45 pm BINDING FREE ENERGY LANDSCAPE OF C-SRC KINASE TO ITS INHIBITORS SAMPLED BY MOLECULAR DYNAMICS SIMULATIONS: EFFECT OF LIGAND SIZE AND FLEXIBILITY. Ai Shinobu, Suyong Re, Yuji Sugita PI to PI A Wine and Cheese Mixer 4:00 pm - 6:00 pm, Room 2 You finally have a job working in biophysics, in industry or academia, with some funding and a lab, but you’ve realized that the career challenges continue. Come relax and network with your contemporaries and senior biophysicists over a beer or glass of wine. This event is a great chance to compare notes with colleagues and discuss one-on-one your unique solutions to issues that arise in the time between getting your job and getting your next promotion, including management of lab staff, getting your work published, and renewing your funding. Refreshments will be provided, with cash bar. Exhibitor Presentation: Fluidic Analytics 4:30 pm - 6:00 pm, Room 10 Introducing Microfluidic Diffusional Sizing (MDS) Technology; Quantify and Characterize Any Protein Interaction – Even in Complex Backgrounds, Even with Challenging Targets Studying protein interactions is of fundamental importance in a wide variety of research fields, including neurobiology, oncology, immunology, structural biology, and molecular biology. The more scientists understand about protein interactions, the more we will know about the inner workings of a cell, and crucially, the better we will understand what happens when normal cellular function is subverted in human disease. But, with a multitude of different technologies on the market, how do researchers know which technique is right for them? Microfluidic Diffusion Sizing technology (MDS) brings a new tool to the analytical characterization toolbox: a different approach that enables the analysis of protein interactions close to in vivo conditions. Measuring What Matters With MDS, scientists can determine affinity of interaction (KD), concen -

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Molecular Dynamics I 4:00 pm - 6:00 pm, Room 11AB

Co-Chairs Rafael Bernardi, Auburn University, USA Yuji Sugita, RIKEN, Japan

172-plat 4:00 pm MOLECULAR MECHANISMS OF BIOFILM FORMATION IN STAPHYLOCOCCI BACTERIA: HOW ANTIBIOTIC RESISTANT BACTERIA IS EVOLVING TO BECOME MORE RESILIENT TO MECHANICAL FORCE LOADS. Priscila S. Gomes, Marcelo Cardoso dos Reis Melo, Diego E. Barreto Gomes, Rafael C. Bernardi 173-plat 4:15 pm FAST, CONFORMATION-INDEPENDENT CHARGES WITH GRAPH CONVO LUTIONAL NETWORKS. Lily Wang , Simon Boothroyd, Joshua T. Hor ton, MatthewW. Thompson, Michael R. Shirts, Daniel J. Cole, John D. Chodera, David L. Mobley

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