Biophysical Society 67th Annual Meeting Program Guide

Platform Protein Structure and Conformation II 4:00 pm - 6:00 pm, Room 6E

830-plat 5:45 pm AAV9 GENE TRANSFER OF N-TERMINAL TRUNCATED CMYBPC AMELIO RATES CARDIAC FUNCTION IN CMYBPC-DEFICIENT MICE. Katherine L. Dominic , Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer Platform Protein-Nucleic Acid Interactions II 4:00 pm - 6:00 pm, Room 6D Co-Chairs Mohammad Ahsan, University of California, Riverside, USA Utkarsh Kapoor, Texas A&M University, USA Travel Award Winner OCT4 INTERPRETS AND ENHANCES NUCLEOSOME DYNAMICS. Jan Huertas Martin , Caitlin M. MacCarthy, Vlad Cojocaru, Hans Schöler 832-plat 4:15 pm Travel Award Winner PRINCIPLES OF DNA CLEAVAGE IN CRISPR-CAS9. Mohammad Ahsan , Łukasz Nierzwicki, Kyle W. East, Jonas Binz, Rohaine V. Hsu, Pablo R. Arantes, Erin Skeens, Martin Pacesa, Martin Jinek, George P. Lisi, Giulia Travel Award Winner NON-SPECIFIC VS SPECIFIC DNA BINDING FREE ENERGETICS OF A TRAN SCRIPTION FACTOR DOMAIN PROTEIN BETWEEN SEARCH AND RECOGNI TION. Carmen Al Masri , Biao Wan, Jin Yu 834-plat 4:45 pm A SINGLE MOLECULE TIRF-BASED PLATFORM TO STUDY DNA SUPERCOIL ING EFFECT ON DNA PROCESSING ENZYMES. Huijin Lee , Taekjip Ha 835-plat 5:00 pm MECHANISM OF ASSEMBLY OF AN ELONGATION-COMPETENT SARS COV2 REPLICATION TRANSCRIPTION COMPLEX. Misha Klein , Subhas C. Bera, Thomas K. Anderson, Bing Wang, Flavia S. Papini, Jamie J. Arnold, Craig E. Cameron, Martin Depken, Robert N. Kirchdoerfer, Irina Artsimov itch, David Dulin 836-plat 5:15 pm HIGH-THROUGHPUT, QUANTITATIVE MEASUREMENTS REVEAL THE BIO PHYSICAL MECHANISMS BY WHICH TRANSCRIPTION FACTOR MUTATIONS DRIVE DISEASE. Renee Hastings , Arjun Aditham, Polly Fordyce 837-plat 5:30 pm MOLECULAR FEATURES UNDERLYING PHASE SEPARATION OF PROTEIN NUCLEIC ACID CONDENSATES REVEALED BY A NEW COARSE-GRAINED DNA MODEL. Utkarsh Kapoor , Youngchan Kim, Jeetain Mittal 838-plat 5:45 pm MULTIVALENT INTERACTIONS BETWEEN RNA AND RNA BINDING PROTEINS DRIVE DIFFERENTIAL INTRA-SPECKLE POSITIONING OF RNA TRANSCRIPTS. Sneha Paul , Mauricio A. Heranandez, Li Wen, Susan Liao, Jiacheng Zhang, Xiaoshu Wang, Oded Regev, Jingyi Fei 831-plat 4:00 pm Palermo 833-plat 4:30 pm

M O N D A Y

Co-Chairs Pooja Kumari, Amity University Jharkhand, India Dana Westmoreland, MIT, USA

839-plat 4:00 pm STRUCTURAL INVESTIGATION OF 2’-AZIDO-2’-DEOXYRIBONUCLEOSIDE-5’- DIPHOSPHATE INHIBITION OF CLASS IA ESCHERICHIA COLI RIBONUCLEO TIDE REDUCTASE. Dana E. Westmoreland , Patricia Feliciano, Catherine L. Travel Award Winner MECHANISM OF SLIDING CLAMP LOADING DURING DNA REPLICATION AND REPAIR IN ATOMIC DETAIL. Xingchen Liu , Christl Gaubitz, Joshua Pajak, Brian A. Kelch 841-plat 4:30 pm STRUCTURAL BASIS OF DOMAIN DESTABILIZATION BY DILATED-CARDIO MYOPATHY-CAUSING MISSENSE MUTATIONS IN TITIN. Ines Martinez Martin , Audrey Crousilles, Elias Herrero-Galan, Diana Velazquez-Carreras, Simon A. Mortensen, Juan Pablo Ochoa, Pablo Garcia-Pavia, David de Sancho, Matthias Wilmanns, Jorge Alegre-Cebollada 842-plat 4:45 pm WHAT DOES ALPHAFOLD KNOW ABOUT PROTEIN FOLDING AND PEPTIDE BINDING. Liwei Chang , Alberto Perez 843-plat 5:00 pm HUMAN DND1-RRM2 FORMS A NON-CANONICAL DOMAIN-SWAPPED DIMER. Pooja Kumari , Neel S. Bhavesh 844-plat 5:15 pm THE PCDDB PROJECT: TOOLS AND RESOURCES FOR CD ANALYSES, AR CHIVING, DISPLAY, AND SHARING. Bonnie A. Wallace , Robert W. Janes 845-plat 5:30 pm THE ROLE OF FILAMENT ASSEMBLY IN REGULATING RETINAL IMPDH1 SPLICE VARIANTS. Justin M. Kollman 846-plat 5:45 pm Travel Award Winner MUTANT CANCER PROTEIN STAT5B HAS TWO DISTINCT CONFORMATION AL STATES. Liam Haas-Neill , Deniz Meneksedag-Erol, Sarah Rauscher Platform Ion Channel Regulatory Mechanisms 4:00 pm - 6:00 pm, Room 6F Co-Chairs Drennan 840-plat 4:15 pm 847-plat 4:00 pm COMPENSATORY CONTROL OF ASSOCIATED ION CHANNEL MRNAS REGU LATES CARDIAC EXCITABILITY. Erick B. Rios Perez , Fang Liu, Margaret B. Jameson, Gail A. Robertson 848-plat 4:15 pm LIPID-DRIVEN CFTR CLUSTERING IS IMPAIRED IN CYSTIC FIBROSIS AND RESTORED BY CORRECTOR DRUGS. Asmahan AbuArish , Elvis Pandzic, Yishan Luo, Yukiko Sato, Mark J. Turner, Paul W. Wiseman, John W. Hanra han 849-plat 4:30 pm CONFORMATIONAL REARRANGEMENTS ASSOCIATED WITH PANX1 CHAN NEL GATING. Jacqueline J. Ehrlich , Erik K. Henze, Toshimitsu Kawate Isabelle Deschenes, Ohio State University, USA Andrea Saponaro, University of Milan, Italy

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