BPS2025 Full Program

974-Plat 4:00 pm INFERRING SINGLE-CELL DYNAMICS OF A MOLECULAR REPORTER FROM UNLABELED LIVE-CELL LIGHT MICROSCOPY DATA ANALYZED WITH DELAY EMBEDDING. Jalim Singh, Jeremy T. Copperman, Laura M. Heiser, Daniel M. Zuckerman 975-Plat 4:15 pm Canceled COMPUTATIONAL MODELING OF YAP PHOSPHORYLATION WITHIN IN TEGRIN ADHESIONS. Hamidreza Jafarinia , Lidan Shi, Haguy Wolfenson, Aurélie Carlier 976-Plat 4:30 pm INTUITIVE, THREE-DIMENSIONAL AGENT-BASED SIMULATION OF COM PLEX MOLECULAR MECHANISMS: APPLICATION TO THE DYNEIN WALK CYCLE. Margot Riggi , Janet Iwasa 977-Plat 4:45 pm MODELING CELLULAR HOMEOSTASIS: AUGMENTING THE BASIC PUMP LEAK DONNAN PROCESS TO ENABLE AUTONOMOUS REGULATORY VOLUME DECREASE. Bela Joos , Ziyi E. Liu, Catherine E. Morris 978-Plat 5:00 pm THE FEEDBACK LOOP BETWEEN SHAPE AND PATTERNING DRIVES MORPHOGENESIS: A CELL-BASED MECHANISTIC MODEL. Bivash Kaity , Daniel Lobo 979-Plat 5:15 pm SYSTEMATIC EMBEDDING OF BIOMECHANICS WITHIN DYNAMICAL GRAPH GRAMMARS WITH APPLICATION TO ACTIN NETWORKS IN DEN DRITIC SPINE HEADS. Eric Mjolsness , Matthew Hur, Thomas M. Bartol, Terrence J. Sejnowski 980-Plat 5:30 pm GENERATIVE COMPUTATIONAL MODELING WITH CELLPACK REVEALS INTERPLAY BETWEEN RULES OF INTRACELLULAR ORGANIZATION AND GEOMETRY IN HIPSCS. Saurabh S. Mogre , Ruge Li, Matheus Palhares Viana, . Allen Institute for Cell Science, Julie A. Theriot, Megan M. Riel Mehan, Graham T. Johnson 2954-Pos 5:45 pm Travel Award Winner Replacement Presenter MULTIPLEXED IMAGING IN LIVING CELLS USING LOGIC AND-GATED FLUOROGENIC RNAS. Sima Khajouei , Ru Zheng, Mingxu You 982-FlashTalk 5:50 pm UNLOCKING THE DYNAMICS OF A BACTERIAL PILUS MACHINE THROUGH A FIVE-MILLION-ATOM SIMULATION. Lixinhao Yang , Diane L. Lynch, Stefan Kreida, Stefano Maggi, Grant J. Jensen, James C. Gumbart 983-FlashTalk 5:55 pm MODELING DIFFUSIVE MOTION OF FERREDOXIN AND PLASTOCYANIN ON THE PSI DOMAIN OF PROCHOLOROCOCCUS AND IMPACTS ON GE NOME WIDE ATP METABOLISM. Aaron Chan , Emad Tajkhorshid, Melih Sener, Zaida Luthey-Schulten Platform Muscle: From Contraction to Regulation 4:00 pm - 6:00 pm, Room 511ABC Co-Chairs Jean-Pierre Benitah, LabEx LERMIT, France Danika Hayman, Imperial College London, United Kingdom 984-Plat 4:00 pm LOCALIZED SYNTHESIS OF CARDIAC EXCITATION-CONTRACTION COU PLING PROTEINS: A DUAL ROLE FOR THE SARCOPLASMIC RETICULUM. Juan I.E. Mariangelo , Anastasia Pokrass, Bennett Yunker, Vladimir Bogdanov, Roman Kalinin, Galina Sakuta, Ali Ulker, Jonathan P. Davis, Sandor Gyorke

985-Plat 4:15 pm A COMPUTATIONAL MODEL OF OXIDATIVE STRESS IN A HUMAN VEN TRICULAR MYOCYTE. Hannah Zukowski , Gonzalo Hernandez Hernan dez, Pei-Chi Yang, Timothy J. Lewis, Colleen E. Clancy 986-Plat 4:30 pm RYR2-V2475F MUTATION IN RABBIT ALTERS ON CARDIOMYOCYTE ELEC TROPHYSIOLOGY. Garance E. Gérard , Jingjing Zheng, Hector H. Valdivia, Francisco Alvarado, Ana M. Gomez, Jean-Pierre Benitah, Romain Perrier 987-Plat 4:45 pm UNEXPECTED NANOSTRUCTURAL REMODELING IN HEARTS OF MICE WITH A LOSS-OF-FUNCTION DEFECT IN THE NAV1.5 SODIUM CHAN NEL. Bianca Ioana Moise , Zoja Selimi, Mikhail Tarasov, Przemysław Radwański, Rengasayee Veeraraghavan 988-Plat 5:00 pm CARDIAC GLYCOSIDE-DRIVEN POSITIVE INOTROPY REQUIRES ALLOSTE RIC INACTIVATION OF THE SODIUM-CALCIUM EXCHANGER BY INTRA CELLULAR SODIUM. Kyle Scranton , Scott John, Rui Zhang, Joshua I. Goldhaber, Riccardo Olcese, Michela Ottolia 989-Plat 5:15 pm RESTORATION OF NAD + DEFICIENCY IMPROVES SINOATRIAL NODE FUNCTION IN HFPEF. Thassio Mesquita , Rodrigo Miguel dos Santos, Aleksandr B. Stotland, Mario Fournier, Weixin Liu, Jennifer Van Eyk, Eduardo Marbán, Eugenio Cingolani 990-Plat 5:30 pm DEVELOPING A MODEL TO STUDY IPSC-CM INTEGRATION WITH HUMAN HEART TISSUE. Danika Hayman , Evangelia Psarrou, Andreia Bernardo, Cesare M. Terracciano 991-FlashTalk 5:45 pm A COMPUTATIONAL MODEL OF ANGIOTENSIN II RECEPTOR TYPE 1 DY NAMICS: INSIGHTS INTO VASCULAR REGULATION. Gonzalo Hernandez Hernandez , Mindy Tieu, Pei-Chi Yang, L. F. Santana, Colleen E. Clancy 992-FlashTalk 5:50 pm Travel Award Winner INVESTIGATING THE MECHANISM OF CARDIAC CELL EXCITABILITY MOD ULATION BY A MEMBRANE-TARGETED PHOTOSWITCH. Chiara Florindi , Ludovica Cestariolo, Vito Vurro, Paola Moretti, Chiara Bertarelli, Antonio Zaza, Guglielmo Lanzani, Jose Felix Rodriguez Matas, Francesco Lodola 993-FlashTalk 5:55 pm S-NITROSYLATION OF CX43 IS REQUIRED FOR Β-ADRENERGIC EN HANCED CARDIAC CONDUCTION AND CONTRACTILITY. Jonathan J. Quan , Manuel F. Munoz Camus, Thao T. Nguyen, Jorge E. Contreras Exhibitor Presentation Molecular Devices 4:30 pm - 6:00 pm, Room 406AB New Minis Analysis in Axon™ pCLAMP™ Software: Minis Search Miniature excitatory post-synaptic currents (mEPSCs) or inhibitory post-synaptic currents (mIPSCs)—also known as “Minis”—are important bioelectrical signals used to communicate among neurons. Minis can be recorded by using an electrophysiology tool in experimental environ ments. Motivated by researchers’ pursuit of enhanced analysis for recorded minis, we have developed the Minis Search feature in the lat est version of our Axon pCLAMP 11.4 software. This new feature offers a streamlined workflow for detecting minis events, enhancing accuracy in measurements, and simplifying event addition and deletion. Join Dr. Jeffrey Tang as he demonstrates how to use Minis Search to perform analysis.

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