BPS2025 Full Program

1315-Pos Board B322 DEUBIQUITINATION OF THE DISTAL C-TERMINUS OF HCN4 CHANNELS PROMOTES SURFACE TRAFFICKING. William G. Nichols , Daniel Enders, Lucas M. Blecker, Avery Langley, Matt J. Graham, Danielle M. Heebner, Colin H. Peters, John Bankston, Kurt G. Beam, Cathy Proenza 1316-Pos Board B323 OXIDATION OF HCN CHANNELS CAUSES RUN-DOWN OF CHANNEL AC TIVITY. Alicia de la Cruz , Alessia Golluscio, Peter H. Larsson 1317-Pos Board B324 ENGINEERING SITES TO BLOCK HCN CURRENT FOR HIGH AFFINITY AND ISOFORM SPECIFICITY. Artiom Butuc , Baron Chanda, Jenna L. Lin 1318-Pos Board B325 Travel Award Winner RNASEQ REVEALS KCNH2’ S REGULATORY ROLE IN GENES LINKED TO DEVELOPMENTAL PROCESSES. Eric N. Jiménez-Vázquez , Abhilasha Jain, David K. Jones 1319-Pos Board B326 EVALUATION OF HERG ACTIVATOR-INDUCED ENHANCEMENT OF HERG PROTECTIVE CURRENTS IN VARIANTS WITH DIFFERENT MECHANISMS OF DYSFUNCTION. Diana V. Hunter , Jake Kemp, Michael Clerx, Raj Johal, Zhaokai Pang, Gary R. Mirams, Tom W. Claydon 1320-Pos Board B327 STOICHIOMETRY OF HERG1 HETEROMERIC CHANNELS. Sudharsan Kannan , Liliana R. Ernandez, Gail A. Robertson 1321-Pos Board B328 RNF61 TARGETS HERG1A/1B FOR ER PROTEIN QUALITY CONTROL. Ya Ching Fang, Chung-Jiuan Jeng, Chih-Yung Tang 1322-Pos Board B329 INVESTIGATING THE EFFECT OF TEMPERATURE AND TRAFFICKING MOD ULATORS ON HERG CURRENT USING HIGH THROUGHPUT AUTOMATED PATCH CLAMP. Maria G. Rotordam, Nadine Becker, Timothy Strassmaier, Søren Friis , Alison Obergrussberger, Michael George, Niels Fertig 1323-Pos Board B330 LANTHANIDES AND THEIR MODULATORY EFFECTS ON THE CARDIAC KV11.1 (HERG) ION CHANNEL. Ebba Åkergren, Amaia Jauregi Miguel , Nina E. Ottosson, Urban Karlsson, Fredrik Elinder 1324-Pos Board B331 A COMPREHENSIVE COMPUTATIONAL ANALYSIS OF LIGAND BINDING SITES IN EAG1 CHANNELS. Kyle C. Kihn , Jeffery B. Klauda, Tinatin I. Brelidze 1325-Pos Board B332 CARDIOTOXIC EFFECTS OF SYNTHETIC CANNABINOID RECEPTOR AGO NISTS: INHIBITION OF HERG AND KV7.1/KCNE1 CHANNELS WITH PRO POSED HERG BINDING SITE. Damon J.A. Frampton, Tanadet Pipatpolkai, Akshay Sridhar, Maryke Venter, Amaia Jauregi Miguel, Henrik Green, Nina E. Ottosson , Sara I. Liin 1326-Pos Board B333 CHLORPROMAZINE INHIBITS EAG1 CHANNELS BY ALTERING THE COU PLING BETWEEN THE PAS, CNBH AND PORE DOMAINS. Ze-Jun Wang , Mahdi Ghorbani, Xi Chen, Purushottam Tiwari, Jeffery B. Klauda, Tinatin Board B334 ELECTROPHYSIOLOGICAL AND STRUCTURAL CHARACTERIZATION OF THE BINDING OF THE CARDIAC ION CHANNEL BLOCKER UCL2077 TO KCNQ1 CHANNELS. Daniel Sastre , Efthymios Kyriakis, Julia Schauer, Magnus Chan, Ying Dou, Jodene R. Eldstrom, Filip Van Petegem, David Fedida I. Brelidze 1327-Pos

1328-Pos Board B335 STRUCTURAL BASIS OF SHAKER KV CHANNEL GATING AND 4-AMINO PYRIDINE BINDING REVEALED BY CLOSED-STATE MODEL. Bernardo I. Pinto , Francisco Bezanilla 1329-Pos Board B336 OPTICAL INVESTIGATIONS OF VOLTAGE-SENSOR DOMAIN ACTIVATION IN K V 2.1/K V 6.4 CHANNELS. Sumeyye Suheda Yasarbas , Michelle Nilsson, Debanjan Tewari, Christian Sattler, Klaus Benndorf, Antonios Pantazis 1330-Pos Board B337 PHASOR FLIM-FRET ANALYSIS OF VOLTAGE SENSOR CONFORMATIONAL HETEROGENEITY IN HERG POTASSIUM CHANNELS. Gucan Dai , Lucas J. Handlin, Erin N. Lessie 1331-Pos Board B338 INFLUENCE OF THE S2S3 LOOP AND CALMODULIN ON THE VOLTAGE SENSOR MOVEMENT AND GATE OPENING IN KV7 CHANNELS. Sara Alicante Martinez , Eider Nuñez, Arantza Muguruza Montero, Marta E. Perez, Maykelis Diaz Solares, Rene Barro-Soria, Alvaro Villarroel 1332-Pos Board B339 CASTING AN AI-POWERED NET: INTEGRATING ALPHAFOLD WITH MOLECULAR DYNAMICS TO IDENTIFY THE NATURAL TARGET OF A CONE SNAIL TOXIN. Izhar Karbat , Sapir Nutkewitz, Daria Adam, Maytal Katz, Eitan Reuveny 1333-Pos Board B340 DEVELOPMENTAL ENCEPHALOPATHY-ASSOCIATED MUTATIONS CAUSE CONSTITUTIVE OPENING OF THE KV7.2 CHANNEL INNER PORE GATE. Agnese Roscioni , Mario Nappi, Giulio Alberini, Alessandro Bersel li, Maria Virginia Soldovieri, Vincenzo Barrese, Sarah Weckhuysen, Ingrid Scheffer, Francesco Miceli, Fabio Benfenati, Luca Maragliano, Maurizio Taglialatela 1334-Pos Board B341 CONFORMATIONAL DYNAMICS OF THE BINDING POCKET REVEAL THE STATE-DEPENDENT HERG CHANNEL BLOCKADE BY DIVERSE DRUG COM POUNDS. Ramya Bandarupalli , Jing Li 1335-Pos Board B342 MOLECULAR DETERMINANTS OF PROPOFOL INHIBITION OF HCN1 CHANNEL FUNCTION. Verena Burtscher , Lei Wang, John Cowgill, Yongchang Chang, Zi-Wei Chen, Christopher Edge, Edward Smith, Alex S. Evers, Baron Chanda 1336-Pos Board B343 WHERE POSITIVITY MEETS SPECIFICITY: A DESIGNER PEPTIDE AS A NOVEL PORE BLOCKER OF THE VOLTAGE-GATED POTASSIUM CHANNEL KV1.5. Mahasweta Nayak , Ruiming Zhao, Steven Goldstein 1337-Pos Board B344 THE EFFECTS OF LONG QT SYNDROME ASSOCIATED MUTATION R231C ON THE CARDIAC IKS CHANNEL. Yahnell Judah , Xiaoan Wu, Marta E. Perez, Peter H. Larsson Ligand-Gated Channels I (Boards B345 - B369) 1338-Pos Board B345 STRUCTURAL EFFECT OF PORE-FACING GLYCOSYLATION ON SYNAPTIC GABA A RECEPTOR. Amin Akbari Ahangar , Jing Li 1339-Pos Board B346 PHARMACOLOGICAL AND BIOPHYSICAL CHARACTERIZATION OF WRPRF A, A NOVEL PEPTIDE MODULATOR OF ASIC3 DESENSITIZATION. Chun Chien , Nien-Du Yang, Shanti M. Amagasu, Victoria Jiang, Bryan D. Moyer, John M. Gilchrist

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