BPS2025 Full Program

1340-Pos Board B347 DHA DIFFERENTIALLY MODULATES ASIC3 THROUGH INTERACTIONS WITH TRANSMEMBRANE RESIDUES. Rebecca Roth , Ramya Bandarupalli, Robert C. Klipp, Jing Li, John Bankston 1341-Pos Board B348 CRYO-EM STRUCTURES OF THE HUMAN P2X1 RECEPTOR REVEAL SUBTYPE-SPECIFIC ARCHITECTURE AND ANTAGONISM BY SUPRAMO LECULAR LIGAND-BINDING. Ismayn A. Ditter , Tommy Shi, Adam Oken, Nicolas E. Lisi, Steven E. Mansoor 1342-Pos Board B349 STRUCTURAL REARRANGEMENTS DURING OPENING OF P2X2 RECEP TOR CHANNELS. Surbhi Dhingra , Kenton Swartz 1343-Pos Board B350 HEARING LOSS MUTATIONS IN HUMAN P2X2 RECEPTOR CHAN NELS. Paula-Luise Wand, Xenia Brünings, Ralf Mrowka, Thomas Zimmer, Klaus Benndorf, Christian Sattler 1344-Pos Board B351 Travel Award Winner MOLECULAR PHARMACOLOGY OF HUMAN P2X7 RECEPTOR LIGANDS VISUALIZED BY CRYO-EM. Adam C. Oken , Andreea L. Turcu, Kyriakos Georgiou, Eva Tzortzini, Jessica Nagel, Yong-Chul Kim, Antonios Kolo couris, Christa E. Muller, Santiago Vazquez, Steven E. Mansoor 1345-Pos Board B352 SYNTHETIC MODULATOR RESCUES GATING DEFICITS IN GLUN1 Y647 DISEASE-RELATED NMDA RECEPTOR VARIANTS. Samantha R. Schwarz , Jamie A. Abbott, Gabriela K. Popescu 1346-Pos Board B353 HOW A PATIENT MUTATION ALTERS THE AMPA RECEPTOR ION CHAN NEL. Alejandra Montaño Romero , Remy Yovanno, Albert Y. Lau, Edward C. Twomey 1347-Pos Board B354 CALCIUM-PERMEABLE AMPA RECEPTORS ASSOCIATED WITH AUXIL IARY PROTEINS ARE BLOCKED BY MEMANTINE. Elisa Carrillo , Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Andreea L. Turcu, Santiago Vázquez, Edward C. Twomey, Vasanthi Jayaraman 1348-Pos Board B355 CONFORMATIONAL DYNAMICS OF AMPA RECEPTOR MODULATOR SELECTIVE FOR TARP-Γ8. Paola Carrillo Flores , Vladmir Berka, Vasanthi Jayaraman 1349-Pos Board B356 Travel Award Winner EXPLORING EXTRACELLULAR UNSTRUCTURED DOMAINS OF AMPA RECEPTOR AUXILIARY PROTEINS USING FRET. Jonathan J. Stallone , Tyler A. Couch, David M. MacLean 1350-Pos Board B357 MECHANISM OF NATURAL POLYAMINE AND ANALOGS MEDIATED INHIBITION OF KAINATE RECEPTOR. Thomas P. Newton , Shanti P. Gang war, Maria V. Yelshanskaya, Muhammed Aktolun, Laura Yen, Kristian Strømgaard, Maria G. Kurnikova, Alexander I. Sobolevsky 1351-Pos Board B358 DECODING LIGAND PREFERENCES: EXPLORING HUMAN CNG AND HCN CHANNEL BINDING DOMAINS FOR NEXT-GEN DRUG DESIGN. Sean Patrick Scott , Angelina Albelo, Harini Kanamarlapudi, Vijay Maranholkar, Ian Arteaga, Jacob A. Leipold, Alexander Vela, Suman Nandy, Richard Willson, Mehmet Sen 1352-Pos Board B359 MECHANISMS UNDERLYING MODULATION OF HUMAN ALPHA3 GLY CINE RECEPTORS BY ZINC AND PROTONS. Kayla J. Kindig , Eric Gibbs, David Seiferth, Philip C. Biggin, Sudha Chakrapani

1353-Pos Board B360 VISUALIZING SINGLE-MOLECULE NANODYNAMICS OF AMPA-TYPE GLUTAMATE RECEPTORS BY HIGH-SPEED ATOMIC FORCE MICROSCO PY. Mikihiro Shibata , Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Motoyuki Hattori 1354-Pos Board B361 CALCIUM MODULATES NMDA RECEPTOR OPEN CHANNEL BLOCKERS THROUGH TWO DISTINCT ALLOSTERIC PATHWAYS. Mae G. Weaver , Gabriela K. Popescu 1355-Pos Board B362 STRUCTURAL STUDIES OF HETEROMERIC GLYCINE RECEPTOR ACTIVA TION BY ORTHOSTERIC AND ALLOSTERIC AGONISTS. Eric Gibbs , Sudha Chakrapani, Emily Klemm, Philip C. Biggin, David Seiferth, Bjarne Fed dersen 1356-Pos Board B363 THE MECHANISM OF PIP2 INHIBITION OF ROD CYCLIC NUCLEOTIDE GATED CHANNEL. Taehyun Park , Crina M. Nimigean 1357-Pos Board B364 TEMPERATURE-RESOLVED CRYO-EM REVEALS GLUTAMATE GATING OF AMPA RECEPTORS. Anish K. Mondal , Elisa Carrillo, Vasanthi Jayaraman, Edward C. Twomey 1358-Pos Board B365 DIRECT INTERACTIONS WITH THE NANODISC SCAFFOLD ALTER THE STRUCTURE OF A PENTAMERIC LIGAND-GATED ION CHANNEL. Vikram Dalal , Wayland W. Cheng 1359-Pos Board B366 HUMAN P2X4 RECEPTOR GATING IS MODULATED BY A STABLE CYTO PLASMIC CAP AND PUTATIVE LIPID BINDING SITES. Tommy Shi , Ismayn Ditter, Adam Oken, Steven E. Mansoor 1360-Pos Board B367 ASYNCHRONOUS SUBUNIT TRANSITIONS PRECEDE ACETYLCHOLINE RECEPTOR ACTIVATION. Mackenzie J. Thompson, Christian J.G. Tessier, Anna Ananchenko, Francois Dehez, Hugues Nury, Corrie J.B. daCosta, Eleftherios Zarkadas, John E. Baenziger 1361-Pos Board B368 GATING AND REGULATION OF KAINATE RECEPTORS. Shanti Pal Gangwar , Maria V. Yelshanskaya, Kirill D. Nadezhdin, Thomas P. Newton, Laura Yen, Muhammed Aktolun, Maria G. Kurnikova, Alexander I. Sobo levsky 1362-Pos Board B369 CRYO-EM STRUCTURES AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN TMEM16E SCRAMBLASE AND GDD ASSOCIATED MUTA TIONS. Eleonora Di Zanni , Nicole Rychlik, Zhang Feng, Elizabeth Kim, Alessio Accardi Membrane Pumps, Transporters, and Exchangers I (Boards B370 - B398) 1363-Pos Board B370 DE NOVO DESIGN AND CHARACTERIZATION OF NOVEL COPPER-TRANS PORTING P1B-TYPE ATPASES. Fernando Montalvillo, Fariha Hossain, Faruck Morcos, Gabriele Meloni, Hedieh Torabifard 1364-Pos Board B371 SUBSTRATE TURNOVER RATE OF NBCE1 AND AE1 SLC4 TRANSPORTERS: STRUCTURE-FUNCTION CONSIDERATIONS. Hristina R. Zhekova , Alex ander Pushkin, Liyo Kao, Rustam Azimov, Natalia Abuladze, Xuesi Shao, Peter D. Tieleman, Ira Kurtz

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