BPS2025 Full Program

1365-Pos Board B372 MOLECULAR DYNAMICS INSIGHTS INTO LIPID AND NUCLEOTIDE MODU LATION OF P-GLYCOPROTEIN TRANSPORT CYCLE. Ahmed Shubbar , Samuel Mwatha, Matthew Brownd, Mortaza Derakhshani-Molayousefi, Mahmoud Moradi 1366-Pos Board B373 PHOSPHOLAMBAN AND SARCOLIPIN SHARE SIMILAR TRANSMEM BRANE ZIPPER MOTIFS THAT CONTROL SELF-ASSOCIATION AFFINITY AND HOMO-OLIGOMER STOICHIOMETRY. Bengt Svensson , Nicholas R. DesLauriers, John E. Rubin, Joseph M. Autry, Seth L. Robia, Razvan L. Cornea, Robyn T. Rebbeck, David D. Thomas 1367-Pos Board B374 FIRST INSIGHTS INTO BIOPHYSICAL AND BIOCHEMICAL CHARACTER ISTICS OF HUMAN SLC45A1. Alice Giusto , Margherita Festa, Abraham Tettey-Matey, Michael Pusch 1368-Pos Board B375 SERCA2A-TARGETED DRUGS FOR TREATMENT OF HEART FAILURE: ME DICINAL CHEMISTRY DEVELOPMENT OF A COMPOUND IDENTIFIED VIA HIGH-THROUGHPUT SCREENING. Osha Roopnarine , Marzena Brink mann, Samantha L. Yuen, T.Y. (Kent) Wong, Kaja Berg, Razvan L. Cornea, Robyn T. Rebbeck, Courtney C. Aldrich, David D. Thomas 1369-Pos Board B376 PHOSPHOLEMMAN RESIDUES 1-37 CONTAINS LOCALIZATION SE QUENCE FOR ITS TARGETING TO INTERCALATED DISCS (IDS) IN CARDIO MYOCYTES. Kazuhiro Aonuma , Jin Guo, Steven E. Cala, Zhenhui Chen 1370-Pos Board B377 MODULATION OF SEROTONIN TRANSPORT BY CHLORIDE IONS. Annika K. Backer , Bethlehem Bekele, Sarah Uchendu, Jiahui Huang, Eva Hells berg, Gary Rudnick, Lucy R. Forrest 1371-Pos Board B378 PRINCIPLES OF TRANSPORT AND MULTIDRUG RESISTANCE IN PROTO TYPICAL SMR TRANSPORTERS. Fabrizio Marinelli , Esam Orabi, Trevor J. Yeh, Emmanuel Barbosa, Randy Stockbridge 1372-Pos Board B379 EXPLORING LIPID-PROTEIN INTERACTIONS AND NUCLEOTIDE BIND ING IN MULTIDRUG RESISTANCE PROTEIN 1 (MRP1): INSIGHTS FROM MOLECULAR DYNAMICS AND FREE ENERGY PERTURBATION SIMULA TIONS. Samuel Mwatha , Ahmed Shubbar, Mathew Brownd, Mortaza Derakhshani-Molayousefi, Mahmoud Moradi 1373-Pos Board B380 DISCOVERY OF NOVEL SMALL-MOLECULE HITS TARGETING SERCA2A FOR THE TREATMENT OF HEART FAILURE. Carlos Cruz Cortes , Eli Anto nio Alonso Fernandez de Gortari, Adam Ard, Jaroslava Seflova, Justus M. Anumonwo, Martin Clasby, L. Michel Espinoza-Fonseca 1374-Pos Board B381 DETERMINING THE STRUCTURAL BASIS OF METAL SELECTIVITY IN THE EGGERTHELLA LENTA NRAMP-LIKE PROTEINS. Jorge O. Guerra , Shamay eeta Ray, Rachelle Gaudet 1375-Pos Board B382 DE-ORPHANIZATION OF ABCC6 BY METABOLIC CRUDE-EXTRACT SCREENING. Caroline Marcher Holm , Hussam H. Nour-Eldin, Henrik Dimke 1376-Pos Board B383 MOLECULAR BASIS OF THE URATE TRANSPORTER URAT1 INHIBITION BY GOUT DRUGS. Yang Suo , Justin G. Fedor, Seok-Yong Lee

1377-Pos Board B384 LIVE-CELL FRET BIOSENSORS FOR HIGH-THROUGHPUT SCREENING TARGETING THE SERCA2A-DWORF COMPLEX. Rebecca L. Schultz , Ingrid Hayden, Samantha Yuen, Andrew R. Thompson, Bengt Svensson, Osha Roopnarine, Robyn T. Rebbeck, David D. Thomas 1378-Pos Board B385 PROTON-DRIVEN ALTERNATING ACCESS IN AN SPNS DRUG TRANSPORT ER FROM MYCOBACTERIUM SMEGMATIS . Kevin L. Jagessar , Samantha Gies, Ali Rasouli, Joanne L. Parker, Ian Miller, Simon Newstead, Emad Tajkhorshid, Reza Dastvan 1379-Pos Board B386 CONFORMATIONAL FREE ENERGY LANDSCAPES OF A GLUTAMATE TRANSPORTER REVEAL ITS TRANSPORT MECHANISM. Ashkan Fakharzadeh , Sundar Thangapandian, Mahmoud Moradi, Emad Tajkhor shid 1380-Pos Board B387 CROSSTALK BETWEEN PHOSPHOINOSITIDE, CHOLESTEROL, AND MEM BRANE TRANSPORTER ABCA1 IN CARDIOVASCULAR DISEASE. Mariam Khan 1381-Pos Board B388 COMPREHENSIVE ANALYSIS OF HUMAN SOLUTE CARRIER SUPERFAMILY IN ALZHEIMER’S DISEASE USING MULTIMODAL SEQUENCING DATA. Yihan Zhao , Gefei Yu, Abigail Thorpe, Marjan Ilkov, Erming Wang, Ming hui Wang, Avner Schlessinger, Bin Zhang 1382-Pos Board B389 CATION BINDING IN THE HUMAN SEROTONIN TRANSPORTER. Eva Board B390 MECHANISM OF LIPID SCRAMBLING BY THE HUMAN SERINC3 PRO TEIN. Puja Banerjee , Mark J. Yeager, Gregory A. Voth 1384-Pos Board B391 A POTASSIUM ODYSSEY: THE PERMEATION PATHWAY OF KDPFABC. Adel K. Hussein , Xihui Zhang, Audri Wong, David L. Stokes 1385-Pos Board B392 ATOMIC-LEVEL FREE ENERGY LANDSCAPE REVEALS COOPERATIVE SYMPORT MECHANISM OF MELIBIOSE TRANSPORTER. Ruibin Liang , Lan Guan 1386-Pos Board B393 MOLECULAR MECHANISMS OF MFSD2A-MEDIATED LYSOLIPID TRANS PORT ACROSS THE BLOOD-BRAIN BARRIER. Maria Margarida Gil dos Santos Silva Rosa, George Khelashvili 1387-Pos Board B394 STRUCTURAL ELEMENTS OF DWORF REQUIRED FOR ACTIVATION OF THE SARCO-ENDOPLASMIC RETICULUM CALCIUM ATPASE (SER CA). M’Lynn E. Fisher, Justin R. Gregory, Howard S. Young 1388-Pos Board B395 STRUCTURAL INSIGHTS INTO THE POLYSPECIFICITY AND TRANSPORT MECHANISM OF HUMAN OCT1. Alastair Stewart 1389-Pos Board B396 MOLECULAR MECHANISM OF THE FAMILIAL HEMIPLEGIC MIGRAINE TYPE2 MUTATION (G301R) IN THE SODIUM PUMP PATHOPHYSIOL OGY. Jaroslava Seflova , Xuan Fang, Peter Kekenes-Huskey, Pablo Artigas, Julie Bossuyt, Seth L. Robia 1390-Pos Board B397 DEPHOSPHORYLATION AND ION BINDING IN PROKARYOTIC CALCIUM TRANSPORT. Irfan Prabudiansyah, Fredrik Orädd, Konstantinos Magka kis, Kevin Pounot, Matteo Levantino, Magnus Andersson Hellsberg 1383-Pos

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