BPS2025 Full Program

1391-Pos Board B398 NOVEL MECHANISM REGULATING ASYMMETRIC DISTRIBUTION OF SIGNALING PHOSPHOLIPID PIP2 ACROSS PLASMA MEMBRANE BI LAYER. Ashutosh Prince , Nilam Bhandari, Kailash Gulshan Ion Channels, Pharmacology, and Disease I (Boards B399 - B422) 1392-Pos Board B399 CC2 SPECIFICALLY ENHANCES KCNQ1 CHANNEL ACTIVATION WITH KCNE1 ASSOCIATION. Lu Zhao , Xianjin Xu, Jingyi Shi, Lu Han, Borui Zhang, Xiaoqin Zou, Jianmin Cui 1393-Pos Board B400 STRUCTURAL BASIS FOR THE PHARMACOLOGICAL MODULATION OF K CA 3.1CHANNELS REVEALED BY THE CRYO-EM STRUCTURES. Alena Ramanishka , Young Woo Nam, Seow Theng Ong, Joshua Nasburg, Xuan Rui Ng, Zhong Zhuang, Yang Xu, Heike Wulff, K George Chandy, Miao Zhang 1394-Pos Board B401 PISIFERIC ACID LIGAND-GATES THE K V 1.1 POTASSIUM CHANNEL TO COR RECT EPISODIC ATAXIA TYPE 1. Rían W. Manville , Lorenzo Foglia, Ryan F. Yoshimura, Amy Nguyen, Alvin Yu, Geoffrey W. Abbott 1395-Pos Board B402 FUNCTIONAL CHARACTERIZATION OF LYSOSOMAL CHANNELS TMEM175 AND TPC2 USING SOLID SUPPORTED MEMBRANE-BASED ELECTROPHYSIOLOGY. Rocco Zerlotti , Andre Bazzone, Maria Barthmes, Niels Fertig 1396-Pos Board B403 EXOGENOUS OLIGOMERIC ALPHA-SYNUCLEIN AFFECTS THE COUPLING BETWEEN DOPAMINE RELEASE AND SPONTANEOUS FIRING DISCHARGE IN MIDBRAIN DOPAMINERGIC NEURONS. Valentina Carabelli , Giulia Tomagra, Anthony Battaglia, Antonio de Iure, Federico Picollo, Emilio Carbone, Barbara Picconi, Paolo Calabresi, Andrea Marcantoni 1397-Pos Board B404 CHLORIDE INTRACELLULAR CHANNELS (CLICS) COMPENSATES CFTR ACTIVITY IN MACROPHAGES. Veronica Loyo-Celis , Alejandra Montañez, Santiago Partida-Sanchez, Murugesan Rajaram, Harpreet Singh 1398-Pos Board B405 ADPKD TAIWAN FOUNDER VARIANT CAUSES LOSS OF PKD2 CHANNEL TRAFFICKING TO THE PRIMARY CILIA. Louise F. Kimura, Orhi Esarte Palomero, Thuy N. Vien, Paul G. DeCaen 1399-Pos Board B406 INVESTIGATING THE ROLE OF ELECTROSTATIC INTERACTIONS BETWEEN CALMODULIN AND CALCIUM ACTIVATED POTASSIUM SK CHANNELS. Lucie Parent , Marlena Broszczak, Juan Zhao 1400-Pos Board B407 ROLE OF THE H V 1 PROTON CHANNEL IN VASCULAR SMOOTH MUSCLE CELLS. Katinka Gyuris , Geraldo J. Domingos, Éva Korpos, Beáta Arnódi - -Mészáros, Martina Piga, Nace Zidar, Zoltan Varga 1401-Pos Board B408 EFFICACY OF COMPOUND 18 IN INHIBITING THE LRRC8 CHANNEL IN MEG01 CELLS. Chloe M. Meyer , Tarek Mohamed, Rajan Sah 1402-Pos Board B409 STRUCTURAL BASIS FOR SAXITOXIN CONGENER BINDING AND NEU TRALIZATION BY ANURAN SAXIPHILINS. Sandra Zakrzewska , Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, Justin Du Bois, Daniel L. Minor

1403-Pos Board B410 TMEM175 CHRONICLES: A JOURNEY FROM HIGH THROUGHPUT SCREENING TO LYSOSOME. Manuel Paina, Katja Blasi, Stella Donato, Fernanda Ricci, Chiara Galimberti, Angela Molteni, Anna Mondini, Jean Francois Rolland 1404-Pos Board B411 ACTION POTENTIAL GENERATION IN NEUROENDOCRINE SMALL CELL LUNG CANCER CELLS. Jodie Collingridge , Hugh P.C. Robinson 1405-Pos Board B412 TARGETING THE PHARMACORESISTANT CAV2.3: FROM VALIDATION TO PRE-CLINICAL THERAPEUTIC CANDIDATES. Federica Gasparri, Anna Mondini, Manuel Paina, Elena Sirtori, Cinzia Nucci, Angela Molteni, Maria Pia Catalani, Daniel Gill, Tom Otis, Paolo Pevarello, Jean-Francois Rolland , Henning Steinhagen 1406-Pos Board B413 Travel Award Winner SYSTEMATIC STRUCTURAL EVALUATION OF POLYCYSTIN VARIANTS BY CRYO-EM. Orhi Esarte Palomero , Paul G. DeCaen 1407-Pos Board B414 PRECISION MODULATION OF AMPA RECEPTORS BY BENZODIOXOLE DERIVATIVES FOR MOTOR RECOVERY IN PARKINSON’S DISEASE. Mohammad Bdair , Mohammad Qneibi 1408-Pos Board B415 DIFFUSING PROTEIN BINDERS TO PLUG THE SODIUM LEAK. Samuel Usher , Fabian Hink, Janina Sörmann, Joseph Rogers, Stephan A. Pless 1409-Pos Board B416 AUTOMATED PATCH CLAMP UNRAVELING THE FUNCTIONAL DYNAMICS OF PATHOGENIC PIEZO1 VARIANTS AND FUNCTIONAL INSIGHTS INTO KCA3.1 CHANNELS ON ERYTHROCYTES. Kian Haseli , Andreas Glenthøj, Jesper B. Petersen, Bo Hjorth Bentzen, Kim Boddum 1410-Pos Board B417 NON-SELECTIVE EFFECTS OF CA V 3 T-TYPE CHANNEL BLOCKERS ML218 & Z944 ON CA V 1 L-TYPE CHANNELS. Jinglang Sun , Juan A. de la Rosa, Adriana H. González, Vladimir Yarov-Yarovoy, Amy Lee 1411-Pos Board B418 TIME-RESOLVED FLUOROMETRY REVEALS NOVEL INSIGHTS INTO SMALL MOLECULE DRUG INTERACTIONS WITH THE HCN CHANNEL VOLTAGE SENSOR. Ian C. Forster , Chaseley E. McKenzie, Magdalena N. Wojciechowski, Andrew Hung, Ming S. Soh, Christopher A. Reid 1412-Pos Board B419 RAPID AND ACCURATE TRANSEPITHELIAL RESISTANCE MEASUREMENT OF BRONCHIOLAR EPITHELIUM USING IMPEDANCE SPECTROSCOPY AND RCRC MODEL. Athena Chien , Colby Lewallen, Guiying Cui, Analia Vazquez Cegla, Erica Lull, Hanna Khor, Nael A. McCarty, Craig Forest 1413-Pos Board B420 CRYO-EM INVESTIGATION OF RYANODINE RECEPTOR TYPE 3. Yu S. Chen , Maricela Garcia-Castañeda, Maria Charalambous, Daniela Rossi, Vincenzo Sorrentino, Filip Van Petegem 1414-Pos Board B421 DEVELOPING AN ADAPTABLE TOOLBOX FOR MEASURING ION CHANNEL STOICHIOMETRY USING STEPWISE PHOTOBLEACHING. Tristan C. Paul , Megan M. Cullinan, John R. Bankston 1415-Pos Board B422 NATURAL PEPTIDE MODULATORS OF RYANODINE RECEPTORS PRO DUCED BY A HIGH-THROUGHPUT EXPRESSION SYSTEM. Li Xiao , Carmen R. Valdivia, Wenxuan Cai, Filip Van Petegem, Hector H. Valdivia

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