BPS2025 Full Program

2638-Pos Board B102 COEVOLUTIONARY MOTIFS ENABLE DISCOVERY OF NOVEL LIPID SPECI FICITY IN MULTIPLE PEPTIDE RESISTANCE FACTOR ENZYME. Jonathan Martin , Priya M. Christensen, Aparna Uppuluri, Luke Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli Palmer 2639-Pos Board B103 COMPLEXATION OF CYTOCHROME P450 17A1 WITH ITS REDOX PROTEINS IN A MEMBRANE: INSIGHTS FROM MOLECULAR DYNAMICS SIMULATION. Jonathan Teuffel , Goutam Mukherjee, Sungho Bosco Han, Rebecca C. Wade 2640-Pos Board B104 STRUCTURE AND ENERGETICS OF PET-HYDROLYZING ENZYMES: A SYSTEMATIC COMPARISON FROM MOLECULAR DYNAMICS SIMULA TIONS. Alessandro Berselli 2641-Pos Board B105 MEASURING PETASE ENZYME KINETICS BY SINGLE-MOLECULE MICROS COPY. Yuwei Zhang , William O. Hancock 2642-Pos Board B106 SINGLE-MOLECULE TRACKING REVEALS DUAL FRONT DOOR/BACK DOOR INHIBITION OF CEL7A CELLULASE BY ITS PRODUCT CELLOBI OSE. Daguan Nong , Zachary K. Haviland, Zexer Zexer, Sarah A. Pfaff, Daniel J. Cosgrove, Ming Tien, Charles T. Anderson, William O. Hancock 2643-Pos Board B107 CARTOGRAPHY OF ELECTRIC FIELDS IN ENZYME CATALYSIS. Srijit Mukherjee , Steven D.E. Fried, Yuezhi Mao, Steven G. Boxer 2644-Pos Board B108 NEURODEGENERATIVE ATPASE VCP MUTANT AND WILD TYPE CO ASSEMBLY, STOICHIOMETRY, AND FUNCTIONAL ASSESSMENT BY SINGLE MOLECULE ASSAYS. Jingxuan Tang , Benjamin Dodd, Guoming Gao, Laxmikanta Khamari, Liuhan Dai, Andreas Schmidt, Stephanie L. Moon, Nils G. Walter 2645-Pos Board B109 PROTEOLYTIC PERFORMANCE IS DEPENDENT ON BINDING EFFICIENCY, PROCESSIVITY AND TURNOVER: SINGLE MOLECULE INSIGHTS. Emily W. Sørensen , Freya Reinhold, Andreas Faber, Steen W.B. Bender, Jacob Kæstel-Hansen, Jeannette Lundin, Errika Voutyritsa, Per Hedegård, Sune M. Christensen, Nikos S. Hatzakis 2646-Pos Board B110 THE SYNTHESIS OF NEUROMODULATORY MOLECULES BY A GUT MI CROBIAL GLUTAMATE DECARBOXYLASE. Pavani Dadi , Clint W. Pauling, Abhishek Shrivastava, Dhara Shah 2647-Pos Board B111 CRYO-EM STRUCTURES OF CHLOROPLAST GLUTAMYL ENDOPEPTIDASE DEFINE ITS CATALYTIC MECHANISM. Jacqueline Ehrlich , Toshimitsu Kawate 2648-Pos Board B112 BREAKING FREE FROM “PHOSPHO-MIMETICS”: RECENT ADVANCES IN GENETIC CODE EXPANSION FOR STUDYING AUTHENTICALLY PHOSPHOR YLATED PROTEINS. Richard B. Cooley , Ryan A. Mehl Intrinsically Disordered Proteins III (Boards B113 - B142) 2649-Pos Board B113 Travel Award Winner CONSTRUCTION OF IDR ENSEMBLES DIRECTLY FROM SEQUENCE THROUGH MULTI-SCALE GENERATIVE MODELING. Borna Novak , Jeffrey M. Lotthammer, Alex S. Holehouse

2650-Pos Board B114 REVEAL SEQUENCE-ENSEMBLE RELATIONSHIPS IN INTRINSICALLY DIS ORDERED PROTEINS USING ATOMISTIC SIMULATIONS. Cong Wang , Bin Zhang 2651-Pos Board B115 STRUCTURAL INSIGHTS INTO AMYLOID-Β OLIGOMERS AND THEIR IM PACT ON MEMBRANE INTEGRITY USING ALPHAFOLD AND MOLECULAR DYNAMICS SIMULATIONS. Yiru Qian , Esmael J. Haddadian 2652-Pos Board B116 INVESTIGATION OF CALIBRATED MARTINI 3 FORCE FIELD FOR STUDYING PROTEIN CONDENSATION AND INTERACTION OF CONDENSATE WITH MEMBRANE. Kairong Dong , Shanlong Li, Jianhan Chen 2653-Pos Board B117 CHARGE REGULATION OF INTRINSICALLY DISORDERED PROTEINS. Dylan Tomares , Souradeep Ghosh, Daniel Palomo, Ammon E. Posey, Matthew R. King, Nikita Gupta, Martin J. Fossat, Rohit V. Pappu 2654-Pos Board B118 INFLUENCE OF CHARGE SEGREGATION AND CHAIN LENGTH ON THE MATERIAL PROPERTIES OF BIOMOLECULAR CONDENSATES. Keerthivasan Muthukumar , Dinesh Sundaravadivelu Devarajan, Youngchan Kim, Jeetain Mittal 2655-Pos Board B119 MOLECULAR INTERACTION NETWORK OF FULL-LENGTH FUS IN PHASE SEPARATED CONDENSATES. Shou-Lin Weng , Jeetain Mittal 2656-Pos Board B120 STICKER STRENGTH MODULATES INTRACHAIN VS. INTERCHAIN TUG-OF WAR IN MULTIVALENT DISORDERED REGIONS. David Moses , Garrett M. Ginell, Alex S. Holehouse, Shahar Sukenik 2657-Pos Board B121 EFFECT OF SALT ON A BOUND PEPTIDE SH3 DOMAIN INTERACTION. Ally F. Mujica , Oluebube Onwuzulu, Jorge Cardoso, Elliott J. Stollar, K. Aurelia Ball 2658-Pos Board B122 UTILIZING HOMO-FRET POLARIZATION DETECTION TO CHARACTERIZE LIQUID-LIQUID PHASE SEPARATION OF PROTEINS IN CELL-FREE LYSATE SYSTEMS. Juyeon Ha , Carolyn E. Mills 2659-Pos Board B123 SALT DISRUPTS THE BINDING PATHWAY OF AN ARKA-ABPSH3 PEPTIDE COMPLEX. Jorge I. Cardoso 2660-Pos Board B124 MONITORING CONFORMATIONAL DYNAMICS AND INTERACTIONS OF P53-TAD VIA AN MSPA NANOPORE. David DeCoeur 2661-Pos Board B125 THE EFFECT OF A DOUBLE MUTATION TO KEY NEGATIVELY CHARGED RESIDUES ON THE BINDING PATHWAY OF THE ARKA-SH3 COM PLEX. Jaden Ali , Oluebube Onwuzulu, K. Aurelia Ball, Elliott J. Stollar 2662-Pos Board B126 UNVEILING THE MOLECULAR MECHANISMS OF N6-METHYLADENOSINE (M 6 A) RECOGNITION BY A NOVEL READER PROTEIN USING FRET AND CALORIMETRIC APPROACHES. Aftab Mollah , Sanjaya Abeysirigunawar dena 2663-Pos Board B127 DIFFERENCES IN KINETICS OF TAU FIBER FORMATION REPORTED BY THIOFLAVIN DYES. An Huang , Zachary J. Donhauser

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