BPS2025 Full Program

169-Plat 4:30 pm OPTICAL TWEEZERS MEASURE MULTIPLE BINDING MODES OF DIVERSE SINGLE-STRANDED NUCLEIC ACID BINDING PROTEINS CORRELATED WITH MULTIPLE BIOLOGICAL PROTEIN FUNCTIONS. Michael Morse , Benjamin Cashen, Ioulia F. Rouzina, Mark C. Williams 170-Plat 4:45 pm CONCERTED DANCE OF PROTEIN ON DNA; CHOREOGRAPHY BY BIND ING AFFINITY AND DNA MOTION. Johan R. van der Maarel , Indresh Yadav, Rajib Basak, Jijo George 171-Plat 5:00 pm MECHANISTIC MODEL FOR EPIGENETIC MAINTENANCE BY METHYL CPG-BINDING DOMAIN PROTEINS. Liuhan Dai , Alexander Johnson Buck, Nils G. Walter 172-Plat 5:15 pm STRUCTURAL BASIS FOR DIMERIZATION AND ACTIVATION OF UVRD FAMILY HELICASES. Ankita Chadda, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt 173-Plat 5:30 pm MECHANISM OF COMEA-DRIVEN DNA UPTAKE DURING NATURAL TRANSFORMATION. Joshua I. Santiago, Ishtiyaq Ahmed, David Dubnau, Matthew B. Neiditch, Keith J. Mickolajczyk 174-FlashTalk 5:45 pm BRIDGING DNA CONTACT ALLOWS E.COLI DPS TO CONDENSE THE NUCLEOID. Sneha Shahu , Natalia Vtyurina, Moumita Das, Anne S. Meyer, Mahipal Ganji, Elio A. Abbondanzieri 175-FlashTalk 5:50 pm Travel Award Winner SMFRET INVESTIGATION OF STRUCTURAL DYNAMICS DURING T-LOOP FORMATION. Arianna Lacen , Hui-Ting Lee 176-FlashTalk 5:55 pm LEDGF PREFERENTIALLY REMODELS HISTONE-DNA INTERACTIONS IN METHYLATED NUCLEOSOMES. Joha Joshi , Micah J. McCauley, Michael Morse, Zelin Shan, Tao Jing, Nicole A. Becker, Ioulia F. Rouzina, Louis J. Maher, Dmitry Lyumkis, Mark C. Williams Platform Protein Structure, Prediction, and Design 4:00 pm - 6:00 pm, Room 502A Co-Chairs Ronald Koder, City College of New York, USA Ruth Pachter, Caltech, USA 177-Plat 4:00 pm HIGH PRECISION DESIGN OF DE NOVO BIOENERGETIC PROTEINS. J. L. Ross Anderson , Ethan Bungay, Cam Mellor, Holly Ford, Ben Hardy, Cath erine Back, Alexia Taylor, Paul Curnow 178-Plat 4:15 pm EXCEPTIONAL NITRIC OXIDE DIOXYGENASE ACTIVITY IN A DYNAMIC ARTIFICIAL HEME PROTEIN. Mia C. Brown, James J. McCann, Paul Mo linaro, Ronald Koder 179-Plat 4:30 pm SEQUENCE-BASED PREDICTION OF PROTEIN DYNAMIC CONTACT MAPS THROUGH FINE-TUNED STRUCTURE PREDICTION MODELS. Diego E. Kleiman , Diwakar Shukla 180-Plat 4:45 pm NOVEL TRANSMEMBRANE TRANSPORTERS DERIVED FROM LATENT GENERATIVE LANDSCAPES. Fariha Hossain, Fernando Montalvillo, Hedieh Torabifard, Gabriele Meloni, Faruck Morcos

181-Plat 5:00 pm HAS ALPHAFOLD LEARNED PHYSICS? Siyuan Du , Ningyi Lyu, Jianpeng Ma, Dan Herschlag 182-Plat 5:15 pm G PROTEIN-BOUND BITTER TASTE RECEPTORS: COMPARISON OF ALPHA FOLD, CRYO-EM, AND MOLECULAR DYNAMICS SIMULATED STRUC TURES. Ruth Pachter , Soo-Kyung Kim, Gaoyuan Liu, William A. Goddard 183-Plat 5:30 pm ESTIMATING ANTIBODY FREQUENCIES IN HUMANS USING A STRUC TURE-BASED APPROACH. Shahlo Solieva , Rumi Habib, Daniel W. Kulp, Gregory R. Bowman 184-FlashTalk 5:45 pm DESIGNING A UNIVERSAL FAB-BINDING MEDITOPE TO USE ANTIBODY FABS AS STRUCTURAL CHAPERONES. Carla Cabal Fernandez , Massimil iano Bonomi, Chiara Rapisarda 185-FlashTalk 5:50 pm COMPUTATIONAL MODEL FOR PREDICTING CA 2+ BINDING AFFINITY OF CALCIUM-BINDING PROTEIN MUTANTS: FREE ENERGY CALCULATION, COEVOLUTION MODELING AND MACHINE LEARNING. Pooja . , Pradipta 5:55 pm MAPPING THE TOPOGRAPHY OF FUNCTIONAL PATHWAYS IN BIOMO LECULAR SYSTEMS. Federica Maschietto , Lucas Lee, Victor S. Batista Platform Spectroscopy: From Forces to Photons I 4:00 pm - 6:00 pm, Room 502B Co-Chairs Emmanuel Margeat, CNRS - Montpellier, France Brenda Wekesa, University of Missouri, USA 187-Plat 4:00 pm INVESTIGATION OF RIBOSOMAL CONFORMATIONAL DYNAMICS DUR ING CO-TRANSLATIONAL TRANSLOCATION. Brenda Wekesa 188-Plat 4:15 pm APPLYING BAYES TO PET-FCS DATA OF COTRANSLATIONAL FOLDING. Annke de Maeyer , Helmut Grubmuller, Lars V. Bock 189-Plat 4:30 pm SITE SPECIFIC TRIPLE LABELING AND 3-COLOR SINGLE MOLECULE FRET RESOLVE A CONFORMATIONAL INTERMEDIATE DURING THE ACTIVA TION OF A G-PROTEIN COUPLED RECEPTOR. Emmanuel Margeat , Leo Bonhomme, Ecenaz Bilgen, Caroline L. Clerte, Philippe RONDARD, Jean-Philippe PIN, Don C. Lamb, Robert Quast 190-Plat 4:45 pm THE INTERPLAY BETWEEN DNA SENSORS AIM2 AND IFI16Β IN INFLAM MASOME INHIBITION BY SINGLE-MOLECULE STUDIES. Sneha Bhat , Eva de Alba 191-Plat 5:00 pm LIBRARY-SCALE SINGLE-MOLECULE FORCE SPECTROSCOPY ON A CHIP. Matthew DeJong , Alexander R. Dunn, Polly Fordyce 192-Plat 5:15 pm REAL-TIME SINGLE PARTICLE TRACKING IN AN ELECTRIC FIELD. Alexis Bandyopadhyay 186-FlashTalk

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S U N D A Y

Johnson 193-Plat

5:30 pm EXPLORING THE RESOLUTION LIMITS OF SINGLE-MOLECULE FRET. Lukas Whaley-Mayda , Yonglei Sun, Quan Wang

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