BPS2025 Full Program

Platform Condensates: From Properties to Physiology and Disease II 4:00 pm - 6:00 pm, Room 515A Co-Chairs Priya Banerjee, University at Buffalo (SUNY), USA Maria Julia Maristany, University of Cambridge, United Kingdom 934-Plat 4:00 pm NETWORK STENGTH AND INTERFACE CONCENTRATION IN MULTICOM PONENT CONDENSATES DETERMINE THEIR ABILITIES TO SUPPRESS FIBRIL FORMATION. Tharun Selvam Mahendran, Anne Bremer, Anurag Singh, Joe Basalla, Melissa R. Marzahn, Tanja Mittag , Priya R. Banerjee 935-Plat 4:15 pm NUCLEOSOME SPACING CAN FINE-TUNE HIGHER-ORDER CHROMATIN ASSEMBLY. Maria Julia Maristany , Lifeng Chen, Stephen Farr, Bryan Gib son, Lynda Doolittle, Sy Redding, Jorge R. Espinosa, Jan Huertas Martin, Rosana Collepardo-Guevara, Michael K. Rosen 936-Plat 4:30 pm DISAGGREGATION OF BIOMOLECULAR CONDENSATES BY MOLECULAR CHAPERONES IS HETEROGENEOUS AT THE SINGLE-CONDENSATE LEVEL. Diangen Lin , Kyle M. Lin, David A. Drummond, Allison H. Squires 937-Plat 4:45 pm SHAPING CONDENSATES: THE ROLE OF PROTEIN STRUCTURE IN MUL TIPHASE SEPARATION. Vikas Pandey , Tomohisa Hosokawa, Yasunori Hayashi, Hidetoshi Urakubo 938-Plat 5:00 pm EFFECTS OF ACIDIC MICROENVIRONMENTS ON NUCLEOLAR FUNC TIONS. Matthew R. King , Avnika Pant, Dylan T. Tomares, Olivia Lazorik, Ruoyao Zhang, Souradeep Ghosh, Rohit V. Pappu 939-Plat 5:15 pm DYNAMICS OF IDPS IN BIOMOLECULAR CONDENSATES FROM MASSIVE ALL-ATOM EXPLICIT-SOLVENT SIMULATIONS. Miloš T. Ivanović , Nicola Galvanetto, Simone A. Del Grosso, Aritra Chowdhury, Andrea Sottini, Daniel Nettels, Robert B. Best, Benjamin Schuler 940-Plat 5:30 pm SYNERGY BETWEEN LIQUID NETWORKS AND SOLID ASSEMBLIES IN CLATHRIN-MEDIATED ENDOCYTOSIS. Brandon T. Malady , Gavin Lebrun, Liping Wang, Eileen Lafer, David Owen, Jeanne C. Stachowiak 941-FlashTalk 5:45 pm STRESS GRANULES BUFFER IMMUNOGENIC DSRNA RELEASED FROM MITOCHONDRIA DURING TRANSLATION INHIBITION. Prerna Narwal , Shovamayee Maharana 942-FlashTalk 5:50 pm DECIPHERING THE RELATIONSHIP BETWEEN FORM AND INHERENT ELECTROCHEMICAL FUNCTION DURING THE PHASE TRANSITION OF AΒ PEPTIDES. Michael Chen , Xiaokang Ren, Yifan Dai 943-FlashTalk 5:55 pm CONDENSATE-PROMOTING DISORDERED REGIONS ARE ENRICHED IN SPECIFIC CELLULAR PATHWAYS WITH SHARED SEQUENCE FEATURES. Shubham Vashishtha , Benjamin R. Sabari

Platform Ion Channel Regulatory Mechanisms 4:00 pm - 6:00 pm, Room 515B

M O N D A Y

Co-Chairs Sara Garcia, Mississippi State University, USA Jessica Swanson, University of Utah, USA 944-Plat 4:00 pm

REGULATION OF KV1.2 BIOGENESIS BY TMEM33. Damayantee Das , Shawn M. Lamothe, Runying Yang, Victoria A. Baronas, Harley T. Kurata 945-Plat 4:15 pm STRUCTURAL BASIS FOR CALCIUM-DEPENDENT GATING OF THE BILE ACID-SENSITIVE ION CHANNEL. Makayla M. Freitas , Eric Gouaux 946-Plat 4:30 pm MEMBRANE LIPID NANODOMAINS MODULATE HCN PACEMAKER CHANNELS IN NOCICEPTOR DRG NEURONS. Lucas J. Handlin , Natalie L. Macchi, Nicolas L.A. Dumaire, Lyuba Salih, Erin N. Lessie, Kyle S. McCom mis, Aubin Moutal, Gucan Dai 947-Plat 4:45 pm A CLOCKWORK GATING MECHANISM OPENS A PROTEO-LIPIDIC PORE IN PIEZO2 CHANNELS. Shu Li, Tharaka D. Wijerathne, Aashish Bhatt, Wenjuan Jiang, Jerome J. Lacroix, Han Wei, Yun Lyna Luo 948-Plat 5:00 pm CALMODULIN-DRIVEN ENHANCEMENT OF MITOCHONDRIAL CALCIUM UPTAKE IN ISOLATED MITOCHONDRIA FROM MICE. Sara Garcia , Anne Neumaier, Anton Xu, Katarina Ermer, Vasco Sequeira, Christopher N. 5:15 pm CONVERTING TASK1 INTO A SMART SENSOR THAT COUNTERACTS OXI DATIVE STRESS IN CELLS. Alberto Russo , Simone Trini, andrea saponaro, Gerhard Thiel, Anna Moroni 950-Plat 5:30 pm UNRAVELING VOLTAGE CONTROL ONE SITE AT A TIME. Jessica M. Swanson 951-FlashTalk 5:45 pm CROSSLINKING UNNATURAL AMINO ACIDS UNRAVEL PERIPHERAL CHANNEL DYNAMICS CRITICAL FOR ORAI1 PORE OPENING. Julia Söllner , Hadil Najjar, Sarah Weiß, Valentina Hopl, Ferdinand Horvath, Magdalena Prantl, Lena Maltan, Adéla Tiffner, Maximilian Fröhlich, Herwig Grabmayr, Matthias Sallinger, Christina Humer, Heinrich Krobath, Thomas Renger, Isabella Derler 952-FlashTalk 5:50 pm FLUORESCENT PROBES OF KATP’S ENZYMATIC ACTIVITY. Shayla Whita ker, Priscilla Rubio, Michael C. Puljung 953-FlashTalk 5:55 pm STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN MAGNESIUM CHANNEL MRS2. Nicholas D. Clark , Louis Tung Faat Lai, Isadora Rocha De Abreu, Peter R. Johnson, Doreen Matthies Johnson 949-Plat

73