Biophysical Society 66th Annual Meeting Program Guide

1431-Symp 11:15 am STRESS RESPONSES OF MICROBIAL COMMUNITIES FROM HYPERSALINE ENVIRONMENTS. Gherman Uritskiy, Diego Gelsinger, AdamMunn, Samantha Getsin, Jocelyne DiRuggiero 1432-Symp 11:45 am DO DEEP MARINE SEDIMENTS HOST UNUSUALLY STABLE ENZYMES? Andrew D. Steen , Taylor M. Royalty, Jenna M. Schmidt, Karen G. Lloyd 1433-Symp 12:15 pm UNVEILING THE HIGH PRESSURE BIOSPHERE WITH NEW EXPERIMENTAL TECHNOLOGIES. Karyn Rogers , Gina Oliver, Anais Cario Symposium Cytoskeleton and Membranes Meet 10:45 am - 12:45 pm, South, Level Three, Room 303/304 Chair Edna Hardeman, University of New South Wales, Australia 1434-Symp 10:45 am MEMBRANE RATCHETING DIRECTS PROGRESSIVE CELL SHAPE CHANGES IN A PULSATILE SYSTEM THROUGH PIP3 LIPID CUES. Todd Blankenship , Dinah Loerke, Timothy Vanderleest, Hui Miao No Abstract 11:15 am SOLUTES AS CONTROLLERS OF ENDOMEMBRANE TENSION AND DYNAM- ICS. Spencer Freeman 1435-Symp 11:45 am ENDOPLASMIC RETICULUM ORGANIZATION IN NEURONAL POLARITY. Ginny Farias 1436-Symp 12:15 pm INTRAVITAL SUBCELLULAR AND SINGLE MOLECULE IMAGING REVEALS MULTIPLE ACTIN FILAMENT POPULATIONS COLLABORATE IN THE RE- MODELLING OF THE SECRETORY GRANULE MEMBRANE. Edna C. Harde- man , Marco Heydecker, Andrius Masedunskas, Seham Ebrahim, Roberto Weigert, Peter W. Gunning Symposium Best of Biophysical Journal : Molecules to Health 10:45 am - 12:45 pm, South, Level Two, Room 201/202/203 Co-Chairs Jane Dyson, Scripps Research Institute, USA Vasanthi Jayaraman, The University of Texas Health Science Center at Houston, USA No Abstract 10:45 am LIFE IN A TIGHT SPOT: HOW BACTERIA SWIM, DISPERSE, AND GROW IN CROWDED SPACES. Sujit Datta No Abstract 11:15 am A CLOSE LOOK AT MOLECULAR INTERACTIONS IN A PROTEIN USED IN OPTOGENETICS: CHANNELRHODOPSIN. Susan L. Rempe No Abstract 11:45 am THE PHYSICAL PHENOTYPE OF BLOOD CELLS IN COVID-19. Jochen R. Guck No Abstract 12:15 pm HOW COLLAGEN GOT ITS STRIPES: MODELLING FIBRILLOGENESIS OF COLLAGEN-LIKE MOLECULES. (PAPER OF THE YEAR) Anđela Šarić

sodium channel and KCa modulators and positive allosteric modulators for GABA channels. Dr Adam Hyman will present data on novel lysosomal and mechanically activated ion channel targets on the Qube automated patch clamp platform. Speakers Adam Hyman, Senior Scientist, Charles River Laboratories Daniel Sauter, Scientific Sales Manager, Sophion Bioscience A/S Heike Wulff, University of California, Davis Exhibits 10:00 am - 4:00 pm, Exhibit Hall ABC Meet the Editors, Biophysical Reports 10:15 am - 11:00 am, South Lobby/Publications Booth Take this opportunity to meet editors of the Society’s newest journal, Biophysical Reports . Editors will be available to talk about the journal and answer questions about where you should submit your work, what will help to get your work published, and what you can expect when you submit. Editor-in-Chief Jörg Enderlein and others will attend. Coffee Break 10:15 am - 11:00 am, Exhibit Hall ABC Exhibitor Presentation Malvern Panalytical 10:30 am - 12:00 pm, Esplanade, Room 158 A Biophysical Toolbox To Predict and Assess the Stability of Biopharmaceuticals and Vaccines The ability to characterize the stability of biotherapeutic products is crucial to the successful development of commercially successful and safe biopharmaceuticals. As a consequence, protein aggregation is recognized by regulatory agencies and the biopharmaceutical industry as a key quality attribute for biotherapeutic products. During this presentation we will introduce the origins and consequences of aggregation in biotherapeu- tics and examine strategies for predicting and quantifying aggregation in biopharmaceutical formulation development. In addition to traditional protein-based therapeutics, we will also cover vaccine development and stability assessment. A vaccine is a biological preparation that provides active acquired immunity to an infectious disease using the causative agent or components of it, to act as antigen inducing antibody without inducing the actual disease. We will introduce vaccine development, address the key challenges associated with each development platforms and introduce the state of the art analytical and biophysical technology solutions. Speakers MatthewMcGann, Pharma & Food Territory Manager, Malvern Panalytical Ronald Soriano, Applications Scientist, Pharma & Food, Malvern Panalyti- cal Symposium Microbial Behavior in Heterogeneous Environments 10:45 am - 12:45 pm, South, Level Three, Room 301/302 Chair Karyn Rogers, Rensselaer Polytechnic Institute, USA 1430-Symp 10:45 am BIOMINING METALS FROM PYRITIC ORES: PHYSIOLOGICAL, BIOCHEMI- CAL, AND BIOPHYSICAL CONSIDERATIONS. Eric Boyd , Devon Payne, Eric Shepard, Rachel Spietz, Yisong Guo, William Broderick, Joan Broderick

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