Biophysical Society 66th Annual Meeting Program Guide

Platform Protein Structure and Conformation II 10:45 am - 12:45 pm, South, Level Two, Room 204/205/206 Co-Chairs Lisa Jones, University of Maryland, USA Mohammadreza Paraan, Florida State University, USA 1437-Plat 10:45 am STRUCTURAL INSIGHT INTO N-DEGRON POLYUBIQUITINATION CATA - LYZED BY UBR1. Minglei Zhao 1438-Plat 11:00 am Travel Award Winner MECHANISM OF THE ALTERATION IN DOMAIN-DOMAIN COMMUNICA - TIONS IN HUMAN P97/VCP ATPASE. Purbasha Nandi , Shan Li, Rod Carlo Columbres, Feng Wang, Dewight Williams, Yu-Ping Poh, Tsui-Fen Chou, 11:15 am RESOLVING THE SEQUENTIAL MOVEMENTS OF CDC48 TO PROCESS SUB - STRATE. Ian Cooney , Peter Shen 1440-Plat 11:30 am IN SITU CRYO-ET OF ER-MITOCHONDRIA CONTACT SITES. Mohammadreza Paraan , Victoria Hewitt, Jake Johnston, Yusuke Hira - bayashi, Franck Polleux, Bridget Carragher, Clint S. Potter 1441-Plat 11:45 am LASER-FREE FLASH OXIDATION (FOX) HYDROXYL RADICAL PROTEIN FOOT - PRINTING SYSTEM ACCURATELY MAPS THE PARATOPE AND EPITOPE OF TNFΑ BOUND TO ADALIMUMAB. Emily E. Chea 1442-Plat 12:00 pm THE APPLICATION OF AN IN-CELL PROTEOME-WIDE STRUCTURAL BIOL - OGY METHOD TO IDENTIFY DRUG-INDUCED INTERACTOME CHANGES. Lisa M. Jones , Christopher S. Mallis 1443-Plat 12:15 pm MODELING NATIVE STATE ENSEMBLES AND MACROMOLECULAR COMPLEXES USING HYDROGEN-DEUTERIUM EXCHANGE ENSEMBLE REWEIGHTING. Kyle C. Kihn, Ally K. Smith, Richard Bradshaw, Lucy R. For - rest, Daniel J. Deredge 1444-Plat 12:30 pm MONITORING LOWMOLECULAR WEIGHT OLIGOMERIC FORMS OF AMY - LOID BETA IN THE EARLY STAGES OF AGGREGATION USING X-RAY FOOT - PRINTING MASS SPECTROMETRY. Darren Thifault, Line G. Kristensen, Sayan Gupta, Ariel Kuhn, Jevgenij Raskatov, Corie Ralston Platform Intrinsically Disordered Proteins 10:45 am - 12:45 pm, South, Level Two, Room 207/208 Co-Chairs Ana M. Melo, Instituto Superior Técnico, Portugal Martin Fossat, Washington University in St. Louis, USA 1445-Plat 10:45 am Travel Award Winner THE CONFORMATIONAL DYNAMICS OF THE FLANKING POLYQ REGIONS IN THE MEMBRANE-BOUND STATE OF HUNTINGTIN EXON 1. Tânia Sousa, Nuno Bernardes, Ana Coutinho, Manuel Prieto, Ana M. Melo 1446-Plat 11:00 am Travel Award Winner THE AGGREGATION KINETICS OF Α-SYNUCLEIN AT NEUTRAL PH UNDER QUIESCENT CONDITIONS. Wing K. Man , Michael A. Metrick, Dillon J. Rinauro, Michele Vendruscolo 1447-Plat 11:15 am DEDUCING THE AFFINITY BETWEEN APOLIPOPROTEIN E AND SOLUBLE AMYLOID-BETA OLIGOMERS USING FLUORESCENCE CORRELATION SPEC - TROSCOPY. Kamila Nurmakova , Zachary Levine Po-Lin Chiu 1439-Plat

1448-Plat 11:30 am OLIGOPYRIDYLAMIDE-BASED PROTEIN MIMETIC INHIBITS CANCER- ASSOCIATED MUTANT P53 AMYLOID-LIKE AGGREGATION AND RESTORES ITS TUMOR SUPPRESSOR FUNCTION. Palanikumar Loganathan, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Ali, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Tatiana Houhou, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub 1449-Plat 11:45 am CHARGE STATE HETEROGENEITY IN SINGLE ALPHA HELICES HELPS MAIN - TAIN HELICITY OVER A LARGE RANGE OF PH VALUES. Martin J. Fossat , Ammon E. Posey, Rohit V. Pappu 1450-Plat 12:00 pm INSIGHT INTO CALCIUM-BINDING MOTIFS OF INTRINSICALLY DISOR - DERED PROTEINS. Estella A. Newcombe , Catarina B. Fernandes, Jeppe E. Lundsgaard, Inna Brakti, Kresten Lindorff-Larsen, Annette E. Langkilde, Karen Skriver, Birthe B. Kragelund 1451-Plat 12:15 pm Travel Award Winner THE INTRINSICALLY DISORDERED FREQUENCY ISOFORMS OF NEUROSPO - RA CRASSA PLAY A DYNAMIC ROLE IN NEGATIVE ARM CIRCADIAN CLOCK REGULATION. Jacqueline Pelham , Joshua Thomas, Alexander E. Mosier, Morgan L. Rhodes, Alex S. Holehouse, Jennifer M. Hurley 1452-Plat 12:30 pm MECHANISTIC ROLES OF TYROSINE PHOSPHORYLATION IN REVERSIBLE AMYLOIDS, AUTOINHIBITION, AND ENDOSOMAL MEMBRANE ASSOCIA - TION OF ALIX. Ruben D. Elias , Bhargavi Ramaraju, Lalit Deshmukh Platform Optical Microscopy and Superresolution Imaging II 10:45 am - 12:45 pm, South, Level Two, Room 209/210/211 Co-Chairs Xiaoyu Shi, University of California, Irvine, USA Jian-Hua Chen, University of California, San Francisco, USA 1453-Plat 10:45 am MULTIMODAL SINGLE-MOLECULE MICROSCOPY WITH CONTINUOUSLY CONTROLLED SPECTRAL RESOLUTION (COCOS). Jonathan Jeffet , Ariel Io - nescu, Yael Michaeli, Dmitry Torchinsky, Eran Perlson, Timothy D. Craggs, Yuval Ebenstein 1454-Plat 11:00 am LABEL-RETENTION EXPANSION MICROSCOPY TOWARD MOLECULAR RESOLUTION. Xiaoyu Shi , Sohyeon Park, Yinyin Zhuang, Ian Seiple, Bo Huang 1455-Plat 11:15 am USE OF SUB-CELLULAR FLUCTUATION IMAGING (SCFI) AS A RAPID ANTIMICROBIAL SUSCEPTIBILITY TEST. Kanasanun Phonrat , Charlotte R. Bermingham, Connor J. Frapwell, Callum Zorn-Singh, Gabriel Gibb, Mat - thew B. Avison, Massimo Antognozzi 1456-Plat 11:30 am WHOLE-CELL QUANTITATIVE IMAGING OF STRUCTURAL CHANGES INDUCED BY SARS-COV-2 USING SOFT X-RAY TOMOGRAPHY. Jian-Hua Chen , Valentina Loconte, Mirko Cortese, Axel Ekman, Mark A. Le Gros, Ralf Bartenschlager, Venera Weinhardt, Carolyn A. Larabell 1457-Plat 11:45 am MOLECULAR CARTOGRAPHY: CHARTING THE SEA OF MOLECULAR ORGA - NIZATION IN LIVE SYNAPSES WITH NANOSCALE PRECISION. Andrew J. Nelson , Qinsi Zheng, Luke D. Lavis, Timothy A. Ryan

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