Biophysical Society 66th Annual Meeting Program Guide

Platform Ligand-Gated Channels II 10:45 am - 12:45 pm, South, Level Two, Room 215/216 Co-Chairs Stephanie A. Heusser, University of Copenhagen, Denmark Josh Levitz, Weill Cornell Medicine, USA 1469-Plat 10:45 am DIVERSE STRUCTURAL MECHANISMS OF MUSCLE-TYPE NICOTINIC RECEP - TOR ANTAGONISM. Md. Mahfuzur Rahman , Tamara Basta, Jinfeng Teng, Myeongseon Lee, Brady T. Worrell, Michael H.B. Stowell, Ryan E. Hibbs 1470-Plat 11:00 am DIFFERENTIAL ROLES FOR THE M2-M3 LINKERS OF SPECIFIC GABA A R SUB - UNITS IN PORE STABILITY AND BENZODIAZEPINE MODULATION. Joseph W. Nors , Marcel P. Goldschen-Ohm 1471-Plat 11:15 am ALLOSTERIC REGULATION OF THE POTASSIUM CHANNEL KTRAB IS FACILITATED BY KTRB'S N TERMINI. Janina Stautz , David Griwatz, Dorith Wunnicke-Kortz, Marina Schrecker, Susann Kaltwasser, Deryck J. Mills, Janet Vonck, Inga Hänelt 1472-Plat 11:30 am Travel Award Winner DIFFERENTIAL INTERACTIONS OF CLOSED, OPEN, AND DESENSITIZED STATES OF THE Α7 NICOTINIC ACETYLCHOLINE RECEPTOR WITH LIPIDIC MODULATORS. Yuxuan Zhuang , Colleen M. Noviello, Ryan E. Hibbs, Rebecca J. Howard, Erik R. Lindahl 1473-Plat 11:45 am ACTIVATION AND PEPTIDE MODULATION OF AN ACID-SENSING ION CHANNEL INVOLVES CONFORMATIONALLY DECOUPLED STATES. Stephanie A. Heusser , Christian B. Borg, Stephan A. Pless 1474-Plat 12:00 pm TMEM16 SCRAMBLASES THIN THE MEMBRANE TO ENABLE LIPID SCRAM - BLING. Maria E. Falzone, Zhang Feng , Omar E. Alvarenga-Cruz, Yangang Pan, ByoungCheol Lee, Xiaolu Cheng, Eva Fortea, Simon Scheuring, Ales - 12:15 pm MECHANISM OF OPEN-CHANNEL BLOCK IN THE CHLORIDE CHANNEL TMEM16A. Andy K.M. Lam , Sonja Rutz, Raimund Dutzler 1476-Plat 12:30 pm Travel Award Winner DISSECTING THE COMPOSITIONAL DIVERSITY OF THE KAINATE RECEPTOR FAMILY WITH SINGLE MOLECULE FLUORESCENCE IMAGING. Joon Lee , Purushotham Selvakumar, Joel Meyerson, Josh T. Levitz Career Development Center Workshop Transitioning Your Career Beyond Academia 11:30 am - 12:30 pm, Esplanade, Room 151 In this session, we will discuss how to build a career development and networking plan to move your career beyond academia, including to industry, government, nonprofits and more. We will address how to find people in these ecosystems, what to say to them and how to actually cre - ate bridges with them so they think of you for opportunities. We will also delve into what you can do now to prepare for a career in these spaces. sio Accardi 1475-Plat

1458-Plat 12:00 pm DIFFUSION AND INTERACTION DYNAMICS OF THE CYTOSOLIC PEROXI - SOMAL IMPORT RECEPTOR PEX5. Katharina Reglinski , Silvia Galiani, Pablo Carravilla, Aurelien Barbotin, Iztok Urbancic, Erdinc Sezgin, Falk Schneider, Dominic Waithe, Wolfgang Schliebs, Ralf Erdmann, Christian Eggeling 1459-Plat 12:15 pm Travel Award Winner SINGLE PARTICLE TRACKING ON CELLS REVEALS NEW INSIGHTS INTO MEMBRANE COMPARTMENTALIZATION AND LIPID DYNAMICS. Francesco Reina , Christian Eggeling, B. Christoffer Lagerholm 1460-Plat 12:30 pm BRIGHTNESS CORRELATION SPECTROSCOPY TRACKS TRANSCRIPTION FACTOR DIFFUSION AS A FUNCTION OF OLIGOMERIC STATE WITHIN LIVE CELL NUCLEAR ARCHITECTURE. Ashleigh N. Solano , Jieqiong Lou, Lorenzo Scipioni, Enrico Gratton, Elizabeth Hinde Platform Muscle Electrophysiology II 10:45 am - 12:45 pm, South, Level Two, Room 212/213/214 Co-Chairs Ademuyiwa Aromolaran, University of Utah, USA Bianxiao Cui, Stanford University, USA 1461-Plat 10:45 am REGULATION OF HERG 1A/1B CHANNELS THROUGH THE MTOR COMPLEX 1 SIGNALING PATHWAY IN LIPOTOXIC HEART. Md. Kamrul Hasan Chowdhury , Kelly A. Aromolaran, Jenny Do, Ademuyiwa S. Aromolaran 1462-Plat 11:00 am CONTRIBUTION OF THE FUNNY CURRENT TO THE FIGHT-OR-FLIGHT HEART RATE INCREASE. Colin H. Peters , Christian Rickert, Stefano Morotti, Pin Liu, Stephanie Gantz, Bruce P. Bean, Eleonora Grandi, Cathy Proenza 1463-Plat 11:15 am PERINEXI ARE PRIVILEGED SITES FOR CARDIAC ACTION POTENTIAL TRANSMISSION VIA EPHAPTIC COUPLING: A FINITE ELEMENT MODELING STUDY. Ena Ivanovic , Jan P. Kucera 1464-Plat 11:30 am INHIBITION OF SODIUM GLUCOSE COTRANSPORTER 1 REDUCES AR - RHYTHMOGENESIS IN DIABETIC RATS. Sathya Velmurugan , Hailey Mair, Guo Yin, Florin Despa, Sanda Despa 1465-Plat 11:45 am AN IN SILICO-IN VITRO PIPELINE FOR DRUG CARDIOTOXICITY SCREENING IDENTIFIES IONIC PROARRHYTHMIA MECHANISMS. Alexander P. Clark , Siyu Wei, Trine Krogh-Madsen, David J. Christini 1466-Plat 12:00 pm CAPTURING HUMAN-LIKE DIGITALIS EFFECT AND CARDIOTOXICITY IN ADULT ZEBRAFISH USING IN VIVO DUAL-EINTHOVEN-LEAD ECG AND EX VIVO EPICARDIAL OPTICAL MAPPING. Yali Zhao, Francia Lopez, Connie Chen, Thomas Issa, Andrew Lin, Morgan Yun, Thao P. Nguyen 1467-Plat 12:15 pm MECHANICAL LOAD AFFECTS THE REGULATION OF CONTRACTILITY OF RAT LIVING MYOCARDIAL SLICES VIA EXTRACELLULAR VESICLES. Laura Nicastro , Argyris Kyriakou, Barrett Downing, Costanza Emanueli, Cesare M. Terracciano 1468-Plat 12:30 pm INTRACELLULAR RECORDING OF CARDIAC ACTION POTENTIALS VIA MEMBRANE ELECTROPORATION. Bianxiao Cui , Zeinab Jahed, Yang Yang, Ching-Ting Tsai

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