Biophysical Society 66th Annual Meeting Program Guide

Career Development Center Workshop The Strategic Postdoc: How to Find & Leverage your Postdoc Experience 2:30 pm - 3:30 pm, Esplanade, Room 151

The presentation will begin by describing a few features that might be better optimized on a custom imager than on a traditional microscope. The openFrame allows complete control of the optical train, enabling fully telecentric designs and the ability to work with optical components from any manufacturer. For example, it is much easier to create a critical illuminator for illuminating large fields, as you are not constricted by the bulk of a traditional microscope frame and have direct access to the objective. Using a critical illuminator with fiber optic can result in 3 times the light intensity at your sample, with a flatter field of view than your standard liquid light guide into a commercial collimator. Perhaps you want to image in two colors simultaneously: you can split the colors in the body of the microscope and greatly reduce the amount of glass each optical pathway encounters. You can go further and select a different tube lens to optimize the resolution onto cameras with smaller pixels, to give a large field of view with a lower price and a more compact footprint. All of these options can be optimized to work with the objec - tive used in your experiment, to capture every last photon and to match resolution and signal-to-noise requirements. In addition to being more flexible and compact, the openFrame is designed to be long-term sustainable, capable of being maintained and supported by any competent microscopist without reliance on proprie - tary information or specialist engineers: and future-proof, by maintaining consistent mounting flanges across all modules. Easy end-user align - ment of all optical components means there is never a need to return the microscope to base for repair, and any damaged components can be replaced on site. Prof. Paul French’s Photonics Group at Imperial College London have con - ceived and developed this framework in conjunction with Cairn Research. Dr. Sunil Kumar from the Imperial group is both one of the inventors and an innovator of this platform. He will offer insights into the motivation behind this new, open, platform. He will share with you the results of some of their experiments, including the inexpensive EasySTORM TIRF (using a multimode laser), live quantitative phase imaging, Fluorescence Lifetime Imaging and Optical Projection Tomography. He will also discuss some of their approaches for autofocus, liquid handling and experimental control. During the talk a pair of technicians will build up an openFrame micro - scope before your eyes. After Dr. Kumar has shared his results, everyone will have the opportunity to see the system function in a number of modalities; from TIRF to fully automated 2-camera fluorescence with phase contrast. Speakers Jeremy Graham, CEO, Cairn Research Sunil Kumar, Research Associate, Imperial College London Snack Break 1:45 pm - 3:00 pm, Exhibit Hall ABC Poster Presentations and Late Posters 1:45 pm - 3:45 pm, Exhibit Hall ABC

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Many PhDs just kind of fall in to a postdoc, rather than thinking about it from a strategic perspective. Your postdoc is never an end in itself; rather it’s a means to another end whether that goal is a faculty position at a research university, a small college, national lab, or perhaps an industry job. Learn how to find postdoc opportunities that will best prepare you for that next step, and how to use your postdoc experience to facilitate the transition to the next step in your career. Education Committee Meeting 3:00 pm - 5:00 pm, South, Level Three, Room 311 Symposium Novel Biomaterials 4:00 pm - 6:00 pm, South, Level Three, Room 301/302 Chair Silvina Matysiak, University of Maryland, USA No Abstract 4:00 pm FUNCTIONAL AND PROGRAMMABLE DNA NANOTECHNOLOGY. Laura Na Liu 1477 -Symp 4:30 pm COMPUTATIONAL MODELING OF MICROCOMPARTMENT ASSEMBLY AND CARGO CONDENSATION. Farzaneh Mohajerani, Michael F. Hagan 1478 -Symp 5:00 pm MECHANICAL PROPERTIES AND ARCHITECTURE OF THE EXTRACELLULAR MATRIX INFLUENCE CELL MIGRATION AND INVASION. Claudia Tanja Mierke 1479 -Symp 5:30 pm CONNECTING MOLECULAR BEHAVIOR TO MACROSCOPIC PROPERTIES OF POLYSACCHARIDES-BASED HYDROGELS. Silvina Matysiak Symposium Oligomeric Chaperones 4:00 pm - 6:00 pm, South, Level Three, Room 303/304 Chair Rachel Klevit, University of Washington,USA No Abstract 4:00 pm ATOMIC VIEW OF MOLECULAR CHAPERONES IN COMPLEX WITH THEIR CLIENTS. Charalampos Kalodimos 1480-Symp 4:30 pm ARCHITECTURE OF OLIGOMERIC J-DOMAIN PROTEINS. Lukasz A. 5:00 pm NOT SO CRYSTAL CLEAR - CRYSTALLINS AND CATARACT. Angela Gronenborn 1481 -Symp 5:30 pm DISORDER, QUASI-ORDER, ORDER: A HOLISTIC VIEW OF SMALL HEAT SHOCK PROTEINS. Rachel Klevit , Amanda F. Clouser, Hannah E. E.R. Baughman, Chris Woods, Maria Janowska, Natalie Stone, Lindsey Ulmer, Matt Bush, Miklos Guttman Joachimiak No Abstract

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