Biophysical Society 66th Annual Meeting Program Guide

Platform Liquid-Liquid Phase Separation II 4:00 pm - 6:00 pm, South, Level Two, Room 201/202/203 Co-Chairs Scott Gorman, St. Jude Children's Research Hospital, USA Anamika Avni, Indian Institute of Science Education, India 1482-Plat 4:00 pm DROPLET ANALYSIS SUITE: A DETERMINANT OF HESSIAN ALGORITHM AND GUI FOR QUANTIFICATION OF BIOMOLECULAR CONDENSATES. Gable M. Wadsworth , Ibraheem Alshareedah, Priya R. Banerjee 1483-Plat 4:15 pm Travel Award Winner PHYSICS-DRIVEN COARSE-GRAINED MODEL FOR BIOMOLECULAR PHASE SEPARATION WITH NEAR-QUANTITATIVE ACCURACY. Jerelle A. Joseph , Aleks Reinhardt, Anne Aguirre, Pin Yu Chew, Kieran O. Russell, Jorge R. Espinosa, Adiran Garaizar, Rosana Collepardo-Guevara 1484-Plat 4:30 pm ARE FUSION ONCOPROTEINS A SOURCE OF DISEASE-RELEVANT, PHASE SEPARATION-PRONE PROTEIN REGIONS? Scott D. Gorman , Hazheen Shirnekhi, Ramiz Somjee, Swarnendu Tripathi, Cheon-Gil Park, Aaron H. Phillips, Bappaditya Chandra, Gitanjali Asampille, Swetha Ramani Joswala, Nidhi Sahni, Jinghui Zhang, Charles G. Mulligan, Madan Babu, Richard Kriwacki 1485-Plat 4:45 pm Travel Award Winner SINGLE-DROPLET VIBRATIONAL RAMAN SPECTROSCOPY ILLUMINATES THE INNER WORKINGS OF PHASE-SEPARATED BIOMOLECULAR CONDEN - SATES. Anamika Avni , Aishwarya Agarwal, Sandeep K. Rai, Ashish Joshi, Anuja Walimbe, Swastik G. Pattanashetty, Samrat Mukhopadhyay 1486-Plat 5:00 pm MEMBRANE SURFACES REGULATE ASSEMBLY OF A RIBONUCLEOPROTEIN CONDENSATE. Wilton T. Snead , Ian Seim, Therese M. Gerbich, Zhongxiu Hu, Amy S. Gladfelter 1487-Plat 5:15 pm QUANTIFYING THE MATERIAL PROPERTIES OF PROTEIN CONDENSATES THROUGH MICROPIPETTE ASPIRATION. Huan Wang , Fleurie Kelley, Chris - tian Hoffmann, Dragomir Milovanovic, Benjamin S. Schuster, Zheng Shi 1488-Plat 5:30 pm COMPARTMENTALIZATION OF TELOMERES THROUGH DNA-SCAFFOLDED PHASE SEPARATION. Amanda Jack , Yoonji Kim, Amy R. Strom, Daniel S. Lee, Byron Williams, Jeffrey M. Schaub, Elizabeth H. Kellogg, Ilya J. Finkel - stein, Luke Ferro, Ahmet Yildiz, Clifford P. Brangwynne 1489-Plat 5:45 pm STATISTICAL METHODS FOR ANALYZING CLUSTERING AND PHASE TRANSI - TIONS OF MULTIVALENT BIOMOLECULES. Aniruddha Chattaraj, Ming Hao Wang, Michael L. Blinov, Leslie M. Loew Platform Molecular Dynamics II 4:00 pm - 6:00 pm, South, Level Two, Room 204/205/206 Co-Chairs Hanne Antila, Max Planck Institute of Colloids and Interfaces, Germany Gregory A. Babbitt, Rochester Institute of Technology, USA 1490-Plat 4:00 pm RECOGNITION OF SINGLE -STRANDED NUCLEIC ACIDS BY SMALL- MOLECULE SPLICING MODULATORS. Sana Akhter , Zhichao Tang, Ankita Ramprasad, Xiao Wang, Mikhail Reibarkh, Jinan Wang, Sadikshya Aryal, Srinivas S. Thota, Junxing Zhao, Justin T. Douglas, Philip Gao, Erik D. Holm - strom, Yinglong Miao, Jingxin Wang 1491-Plat 4:15 pm CONSTANT-PH MOLECULAR DYNAMICS SIMULATIONS OF A PROTON- GATED ION CHANNEL. Anton Jansen , Paul Bauer, Rebecca J. Howard, Erik Lindahl, Berk Hess

1492-Plat 4:30 pm BEYOND BELL’S LAW: MODEL FREE TRANSITION RATE ESTIMATION FROM NONEQUILIBRIUM TRAJECTORIES. Benjamin D. Kuznets-Speck , David T. Limmer 1493-Plat 4:45 pm AN AUTOMATED FORCE FIELD OPTIMIZATION TOOL FOR HIGH-FIDELITY LIPID MODELS. Hanne S. Antila , Markus S. Miettinen 1494-Plat 5:00 pm COARSE-GRAINED SIMULATIONS OF CURVATURE INDUCED LIPID SORT - ING IN COMPLEX MEMBRANES. Melanie König , Weria Pezeshkian, Siewert J. Marrink 1495-Plat 5:15 pm Travel Award Winner STRUCTURAL CHARACTERIZATION OF PSMA1 FUNCTIONAL AMYLOIDS IN S. AUREUS BIOFILM. Chloe Luyet , Paolo Elvati, Yichun Wang, Changjiang Liu, J. Scott VanEpps, Nicholas Kotov, Angela Violi 1496-Plat 5:30 pm AI-DRIVEN PREDICTION OF BINDING TRENDS OF SARS-COV-2 VARIANTS FROM ATOMISTIC SIMULATIONS. Sara Capponi , Shangying Wang, Erik Navarro, Simone Bianco 1497-Plat 5:45 pm THE FUNCTIONAL EVOLUTION OF ACE2 RECEPTOR BINDING OF BE- TACORONAVIRUSES IN THE PAST, PRESENT, AND UNCERTAIN FUTURE. Gregory A. Babbitt Platform RNA Structure and Dynamics 4:00 pm - 6:00 pm, South, Level Two, Room 207/208 Co-Chairs Travel Award Winner CHARACTERIZING THE RUGGED CONFORMATIONAL ENERGY LANDSCAPE OF RNA. Sukjin S. Jang , Sarah Dubnik, Colin Nuckolls, Ruben L. Gonzalez 1499-Plat 4:15 pm DETERMINISTIC INSIGHTS INTO CO-TRANSCRIPTIONAL FOLDING OF CYCLIC-DI-NUCLEOTIDE RIBOSWITCHES. Albrecht E. Voelklein , Tom Land - graf, Oliver Binas, Boris Fuertig, Christian Richter, Harald Schwalbe 1500-Plat 4:30 pm RNA HAIRPIN FOLDING DYNAMICS IN A CELL. Hyejin Yoo , Caitlin Davis 1501-Plat 4:45 pm ROBUST AND QUANTITATIVE DETECTION OF RNA DYNAMICS WITH FLUORESCENCE LIFETIME-BASED SENSORS IN LIVE MAMMALIAN CELLS. Esther Braselmann 1502-Plat 5:00 pm HEXANUCLEOTIDE REPEAT INDUCED NUCLEAR EXPORT AND TRANSLA - TION OF CIRCULAR INTRONIC RNA IN C9ORF72-ALS/FTD. Malgorzata J. Latallo , Shaopeng Wang, Zhe Zhang, Bo Huang, Dmitriy G. Bobrovnikov, Daoyuan Dong, Nathan M. Livingston, Wilson Tjoeng, Lindsey R. Hayes, Jeffrey D. Rothstein, Lyle W. Ostrow, Bin Wu, Shuying Sun 1503-Plat 5:15 pm CELLULAR ATP LEVELS ARE PARAMOUNT FOR GOVERNING STABILITY AND LLPS OF CAG REPEAT-CONTAINING RNAS INSIDE CELL. Alexander Hautke , Arthur Voronin, Fathia Idiris, Alexander H. Schug, Simon Ebbinghaus 1504-Plat 5:30 pm INVESTIGATING FLAVIVIRAL GENOMIC CYCLIZATION. Tyler Mrozowich , Sean M. Park, Michael T. Wolfinger, Trushar R. Patel Esther Braselmann, Georgetown University, USA Malgorzata Latallo, Johns Hopkins University, USA 1498-Plat 4:00 pm

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