Biophysical Society 66th Annual Meeting Program Guide

1834-Pos Travel Award Winner PRESENILIN 1 REGULATES ENDOPLASMIC RETICULUM CALCIUM TRANS - PORT BY CARDIAC SERCA AND RYR. Elisa Bovo , Roman Nikolaienko, Daniel Kahn, Ellen E. Cho, Seth L. Robia, Aleksey V. Zima 1835-Pos Board B293 FRET-BASED TRILATERATION RESOLVES DISTINCT STRUCTURAL STATES AND TRANSITIONS OF CALMODULIN BOUND TO RYANODINE RECEP - TORS. Bengt Svensson , Robyn T. Rebbeck, Jingyan Zhang, Donald M. Bers, David D. Thomas, Razvan L. Cornea 1836-Pos Board B294 NANOSCALE ORGANIZATION OF RYANODINE RECEPTOR DISTRIBUTION AND PHOSPHORYLATION PATTERN DETERMINES THE DYNAMICS OF CALCIUM SPARKS. María Hernández Mesa , Jonas van den Brink, William E. Louch, Kimberly J. McCabe, Padmini Rangamani 1837-Pos Board B295 CA 2+ WAVES AND THE ARRHYTHMOGENICITY PARADIGM: ROLE OF SERCA STIMULATION IN A CPVT MOUSE MODEL. Ruben Jose Lopez Dicuru , Miguel Fernandez-Tenorio, Radoslav Janicek, Ana M. Gomez, Marcel Eg - ger, Ernst Niggli 1838-Pos Board B296 PHOSPHORYLATION OF CARDIAC RYANODINE RECEPTOR (RYR2): A STRUCTURE-FUNCTION STUDY OF PHOSPHOMIMETIC AND PHOSPHO- NULL TRIPLE MUTANTS. Yifan Hu , Kavita A. Iyer, Ashok R. Nayak, Jose M. Eltit, Nagomi Kurebayashi, Takashi Murayama, Montserrat Samso 1839-Pos Board B297 THE ROLE OF THE N-TERMINAL REGION OF HUMAN TYPE 2 RYANODINE RECEPTOR IN INTERSUBUNIT CROSS-LINKING AND CA 2+ LEAK INDUCED BY OXIDATIVE STRESS. Roman Nikolaienko , Elisa Bovo, Daniel Kahn, Robyn T. Rebbeck, Razvan L. Cornea, Aleksey V. Zima 1840-Pos Board B298 Travel Award Winner MOLECULAR MECHANISMS OF THE MITOCHONDRIAL CALCIUM UNI - PORTER PART 1: STRUCTURAL AND FUNCTIONAL MECHANISMS OF MICU-DEPENDENT CA 2+ ACTIVATION. Chen-Wei Tsai , Ming-Feng Tsai 1841-Pos Board B299 A NEW SOFTWARE FOR DETECTION OF CALCIUM SPARKS IN CARDIAC MYOCYTES. Jakub Tomek , Christopher Y. Ko, Donald M. Bers 1842-Pos Board B300 UNDERSTANDING CALMODULIN REGULATION OF RYR1 THROUGH STEADY STATE AND STOPPED-FLOW FLUORESCENCE DETECTION OF CA 2+ BINDING KINETICS TO CALMODULIN BOUND TO PURIFIED FULL-LENGTH RYR1. Jingyan Zhang , Megan R. McCarthy, Levy M. Treinen, Skylar Mast, Jacob A. Schwarz, David D. Thomas, Razvan L. Cornea 1843-Pos Board B301 EXCLUSIVE MICU1-MICU2 DIMERIZATION IN THE MITOCHONDRIAL CAL - CIUM UNIPORTER COMPLEX IS ACHIEVED THROUGH MITOCHONDRIAL PROTEIN IMPORTATION MECHANISMS. Madison Rodriguez Muscle Regulation (Boards B302 - B307) 1844-Pos Board B302 Travel Award Winner MECHANICAL STRETCHING OF MUSCLE CELLS INDUCES GLOBAL GENE EXPRESSION AND ALTERNATIVE SPLICING CHANGES AND ALTERATIONS IN SR PROTEINS. Emma Hinkle , Yi-Hsuan Tsai, Jacquelyn Davi, Alisha Cof - fey, Aladin Boriek, Joel Parker, Jimena Giudice 1845-Pos Board B303 PREDICTING UNDERLYING PATHOLOGY IN SIMULATED CARDIAC MUSCLE TWITCHES. Anthony Asencio , Sage Malingen, Michael Regnier, Thomas L. Daniel, Farid Moussavi-Harami Board B292

1846-Pos Board B304 CONDITIONALLY MYOPATHIC EFFECTS OF EXON 8 DELETING MUTATION OF SLOW SKELETAL MUSCLE TROPONIN T IN COMPOUND HETEROZY - GOUS TRANSGENIC MOUSE MODEL. Han-Zhong Feng , Jian-Ping Jin 1847-Pos Board B305 REPLATING OF HUMAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYO - CYTES ALTERS MYOSIN HEAVY CHAIN EXPRESSION AND CONTRACTILE PARAMETERS. Felix Osten , Natalie Weber, Bogdan Iorga, Meike Wend - land, Tim Holler, Santoshi Biswanath, Alea K. Bodenschatz, Birgit Piep, Simon Kröhn, Jana Teske, Annika Franke, Robert Zweigerdt, Joachim D. Meißner, Theresia Kraft 1848-Pos Board B306 Travel Award Winner MACHINE LEARNING MODEL PREDICTS THE EFFECTS OF TROPOMYOSIN RIGIDITY ON CARDIAC MUSCLE CONTRACTION. Yasser Aboelkassem , Dragana Savic 1849-Pos Board B307 MEASURING THE BARRIER FUNCTION OF SKELETAL MUSCLE IN INDIVIDU - ALS WITH MUSCULAR DYSTROPHY. Paul S. Blank, Adriana E. Golding , Ivonne Morales Benavides, Hang Waters, Elena Mekhedov, Ludmila Bez - rukov, Rebecca Wachter, Irina Mikhailenko, Robert H. Brown, Jr, Carsten Bonnemann, Andrew Demidowich, Mina Jain, Jack Yanovski, Joshua Zimmerberg Ligand-Gated Channels II (Boards B308 - B325) 1850-Pos Board B308 CONFORMATIONAL TRANSITIONS AND LIGAND-BINDING TO A MUSCLE- TYPE NICOTINIC ACETYLCHOLINE RECEPTOR. John E. Baenziger , Elefthe - rios Zarkadas, Eva Pebay-Peyroula, Mackenzie Thompson, Guy Schoehn, Tomasz Uchański, Jan Steyaert, Christophe J. Chipot, Francois Dehez, Hugues Nury 1851-Pos Board B309 PUFAS STABILIZE ASICS OPEN STATE THROUGH AN ELECTROSTATIC INTER - ACTION WITH OUTER TM1. Robert C. Klipp , John Bankston 1852-Pos Board B310 DISPARATE EFFECTS OF CAM N- AND C-LOBE CPVT-LINKED MUTATIONS ON SK CHANNEL-CAM ASSEMBLY. Benjamin Y. Martin , Catherine Berry, Shanna Hamilton, Jonathan P. Davis, Dmitry A. Terentyev 1853-Pos Board B311 Travel Award Winner AMPA RECEPTOR COMPLEXES WITH TYPE II TARP GAMMA-5 AND GSG1L. Oleg Klykov , Shanti Pal Gangwar, Maria V. Yelshanskaya, Laura Yen, Alexander I. Sobolevsky 1854-Pos Board B312 PHARMACOLOGICAL CHARACTERIZATION OF A PRIMARY NICOTINIC RECEPTOR FROM THE NEUROMUSCULAR JUNCTION. Andrew Cook , Muthukrishnan Renganathan, Dazhi Xiong, Cassidy Kilpack, Ali Yehia, Board B313 EFFICIENCY: AN AGONIST ATTRIBUTE THAT LINKS BINDING AND GAT - ING. Dinesh Indurthi , Anthony Auerbach 1856-Pos Board B314 INVESTIGATING THE CONFORMATIONAL DYNAMICS OF PHOSPHOLIPID SCRAMBLASE PROTEIN TMEM16F IN VITRO. Sameer Rajesh , Vladmir Berka, Eleonora Di Zanni, Zhang Feng, Maria Falzone, Alessio Accardi, Vasanthi Jayaraman 1857-Pos Board B315 DETERMINATION OF BINDING AFFINITY AND EFFICACY FOR NMDA RECEPTOR AGONISTS AND GLUN2A SELECTIVE ALLOSTERIC MODULA - TORS. James Lotti , Kasper Hansen Bryan Koci 1855-Pos

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