Biophysical Society 66th Annual Meeting Program Guide

98 -Plat 12:30 pm EXPANDED REPERTOIRE OF POLARIS, A VERSATILE FLUORESCENT PROBE FOR MOLECULAR ORIENTATION. Nori Nakai, Keisuke Sato, Tomomi Tani, Masahiko Kawagishi, Hiromasa Ka, Kenta Saito, Sumio Terada Platform Protein Stability, Folding, and Chaperones 10:45 am - 12:45 pm, South, Level Two, Room 207/208 Co-Chairs PARAMAGNETIC RELAXATION ENHANCEMENT NMR REVEALS THE STRUC- TURES AND RIBOSOME INTERACTIONS OF NASCENT CHAINS DURING BIOSYNTHESIS. Julian O. Streit , Ivana V. Bukvin, Charity Hornby, Tomasz Wlodarski, Haneesh Sidhu, Christopher A. Waudby, Lisa D. Cabrita, Anais M. Cassaignau, John Christodoulou 100 -Plat 11:00 am THE CLPP PEPTIDASE GRIPS PROTEIN SUBSTRATE AGAINST EXTERNAL FORCE. Steven D. Walker , Adrian O. Olivares 101 -Plat 11:15 am CHANGING THE VECTORIAL SYNTHESIS OF HALOTAG THROUGH CIRCU- LAR PERMUTATION MODULATES AGGREGATION PROPENSITY IN CELLS. Natalie R. Dall , Susan Marqusee 102 -Plat 11:30 am Travel Award Winner AP PROFILING: RESOLVING CO-TRANSLATIONAL PROTEIN FOLDING PATH- WAYS AND CHAPERONE INTERACTIONS IN VIVO . Xiuqi Chen , Christian 11:45 am STABILITY, COUPLING, AND THE PARTLY-FOLDED STATES OF TOPOISOMER- ASE V. Mark Petersen , Rebecca Fang, Ananya Majumdar, Doug Barrick 104 -Plat 12:00 pm DISSECTING THE STRUCTURAL BASIS OF HUNTINGTIN PATHOGENESIS: ONE MOLECULE AT THE TIME. Piere Rodriguez-Aliaga , Robert P. Sosa, Carlos Bustamante, Judith Frydman 105 -Plat 12:15 pm HSC70 MEDIATED DISAGGREGATION OF A-SYNUCLEIN FIBRILS. Matthias M. Schneider , Saurabh Gautam, Therese W. Herling, Georg Krainer, Ewa Andrzejewska, Andreas Bracher, Christopher M. Dobson, Ulrich Hartl, Tuomas P. Knowles 106 -Plat 12:30 pm Travel Award Winner ACCELERATED OXIDATIVE AGING IN DEAMIDATED VARIANTS OF THE HU- MAN EYE LENS PROTEIN GAMMA(S)-CRYSTALLIN. Brenna Norton-Baker , PedramMehrabi, Ashley Kwok, Kyle Roskamp, Marc Sprague-Piercy, David von Stetten, R. J. Dwayne Miller, Rachel W. Martin Platform Protein-Nucleic Acid Interactions I 10:45 am - 12:45 pm, South, Level Two, Room 209/210/211 Co-Chairs Roger Zou, Johns Hopkins University, USA Kathryn Lebold, NIH, USA 107-Plat 10:45 am HIGH-RESOLUTION IMAGING OF THE INTERPLAY OF REPLICATIVE PRO- TEINS ON DNA USING CORRELATIVE TWEEZER FLUORESCENCE MICROS- COPY. Longfu Xu , Matthew T.J. Halma, Gijs J.L. Wuite Natalie Dall, University of California, Berkeley, USA Piere Rodriguez-Aliaga, Stanford University, USA 99 -Plat 10:45 am M. Kaiser 103 -Plat

108 -Plat 11:00 am PICH-INDUCED NUCLEOSOME REMODELING STUDIED BY DUAL-TRAP OPTICAL TWEEZERS. Tinka V.M. Clement , Dian Spakman, Andreas S. Biebricher, Graeme A. King, Manika I. Singh, Ian D. Hickson, Erwin J.G. Peterman, Gijs J.L. Wuite 110 -Plat 11:30 am TUNING THE FORMATION OF PROTEIN-NUCLEIC ACID CONDENSATES. Kathryn M. Lebold , Robert B. Best 111 -Plat 11:45 am Travel Award Winner FINDING AND CLEAVING A HOLLIDAY JUNCTION IN LONG DOUBLE- STRANDED DNA: A COMPLETE RESOLUTION REACTION TRAJECTORY BY SINGLE-MOLECULE TRACKING. Artur Kaczmarczyk , Anne-Cécile Déclais, Matt D. Newton, David M.J. Lilley, David S. Rueda 112 -Plat 12:00 pm ULTRAFAST TWIST MEASUREMENTS RESOLVE SHORT RANGE DSDNA TRANSLOCATION DURING ATP-DRIVEN INITIATION OF DNA SLIDING BY ECOP15I. Martin Göse , Emma Magill, Fiona Diffin, Mark Szczelkun, Ralf Seidel 113 -Plat 12:15 pm HETEROGENEITY OF CRISPR-CAS9 BINDING, CLEAVAGE, AND DNA DAM- AGE RESPONSES AT ENDOGENOUS LOCI. Roger S. Zou , Yang Liu, Hans B. Liu, Alberto Marin-Gonzalez, Jay X.J. Luo, Taekjip Ha 114 -Plat 12:30 pm BINDING AND COMPACTION FUNCTION OF STRUCTURAL DOMAINS OF SARS-COV-2 NUCLEOCAPSID (N) PROTEIN ON A SINGLE STRANDED NU- CLEIC ACID SUBSTRATE. Michael Morse , Jana Sefcikova, Ioulia Rouzina, Penny J. Beuning, Mark C. Williams Platform Voltage-Gated Channels I 10:45 am - 12:45 pm, South, Level Two, Room 212/213/214 Co-Chairs Fayal Abderemane-Ali, University of California, San Francisco, USA Michael Lenaeus, University of Washington, USA 115 -Plat 10:45 am TAMOXIFEN COMPLEXES WITH THE VOLTAGE-GATED SODIUM CHANNEL REVEAL NOVEL DRUG BINDING SITES. David Hollingworth , Bonnie A. Wallace, Altin Sula 116 -Plat 11:00 am OPEN-STATE STRUCTURE AND PORE GATING MECHANISM OF THE CARDIAC SODIUM CHANNEL. Daohua Jiang, Richard L. Banh, Tamer M. Gamal El-Din, Lige Tonggu, Michael J. Lenaeus , Regis Pomes, Ning Zheng, William A. Catterall 117-Plat 11:15 am OPEN STATE OF BACTERIAL SODIUM CHANNEL: INSIGHTS FROMMOLEC- ULAR DYNAMICS SIMULATIONS. Koushik Choudhury , Marina Kasimova, Sarah McComas, Rebecca J. Howard, Lucie Delemotte 118 -Plat 11:30 am SIZE AND DRUG ACCESSIBILITY OF FENESTRATIONS IN VOLTAGE-GATED SODIUM CHANNEL SUBTYPES. Elaine Tao , Ben Corry

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