Biophysical Society 66th Annual Meeting Program Guide

129-Plat 12:15 pm SPECTROSCOPY STUDIES OF THE HUMAN MITOCHONDRIAL ABCB10 TRANS - PORTER. Alexandra Saxberg, Annabella Nouel, Maria E. Zoghbi 130-Plat 12:30 pm STRUCTURES OF MULTIDRUG RESISTANCE PROTEIN MRP4 REVEAL BASIS OF SUBSTRATE SPECIFICITY. Sergei Pourmal Undergraduate Student Pizza “Breakfast” 11:30 am - 1:00 pm, Esplanade, Room 155 Connect with other undergraduates at this “breakfast” for a valuable networking and social opportunity. You will also have a chance to meet and talk to Biophysical Society Committee members, and scientists at all career levels to discuss academic goals and questions and learn how to develop a career path in biophysics. Hear from invited speaker(s) who will share their stories and answer questions. Space for this session is limited to the first 100 attendees. Exhibitor Presentation Carl Zeiss Microscopy LLC 11:30 am - 1:00 pm, Esplanade, Room 157 The ZEISS LSM 9 Series – Redefining Your Confocal Experience The confocal experience continues to evolve with the new features available on the ZEISS LSM 9 Series. As your model systems continue to get larger in order to address the relevant physiological questions, we continue to push the limits of speed, resolution, and sensitivity, as well as spectral flexibility to meet these demands. This includes our revolutionary Airyscan 2 technology, the most sensitive NIR detection available, and now advanced, but easy to use processing tools such as LSM Plus, to ensure that you obtain the best im - age quality at any budget. Furthermore, we now talk about entire workflows by incorporating AI based tools both for acquisition and analysis. From images to results, our powerful ZEN software has unique, efficient, and easy to use strategies to ensure you have the best images and data possible as well as so - phisticated, but user-friendly data and image analysis, including many options for machine learning and automation. Join us in learning about the latest new software and hardware features available on the ZEISS LSM 9 Series confocal microscope systems. Speaker Samantha Fore, Product Marketing Manager Laser Scanning Microscopy Life Sciences, Carl Zeiss Microscopy LLC Career Development Center Workshop Demystifying the Academic Job Search I: Understanding the Search Process from the Perspective of Search Committees and Decoding Job Announcements 12:00 pm - 1:00 pm, Esplanade, Room 151 What goes on inside search committees; the “black box” of the academic job search process? How are they constituted, what are their processes, and what do they look for when assessing applicants? Answers to these and other questions presented by Andrew Green, PhD a veteran of the academic job search and numerous search committees.

119-Plat 11:45 am EVIDENCE THAT TOXIN RESISTANCE IN POISON BIRDS AND FROGS IS NOT ROOTED IN SODIUM CHANNEL MUTATIONS AND MAY RELY ON "TOXIN SPONGE" PROTEINS. Fayal Abderemane-Ali , Nathan D. Rossen, Megan E. Kobiela, Robert Z. Craig, Catherine E. Garrison, Zhou Chen, Claire M. Colleran, Lauren A. O'Connell, Justin Du Bois, John P. Dumbacher, Daniel Travel Award Winner LRRC10 IS A VERSATILE MODULATOR OF CARDIAC FOUR-DOMAIN VOLT - AGE-GATED CHANNELS. Pedro J. del Rivero Morfin , Nourdine Chakouri, Papiya Choudhury, Sergej Borowik, Henry M. Colecraft, Manu Ben-Johny 121-Plat 12:15 pm Travel Award Winner MOLECULAR MOVEMENTS UNDERLYING VOLTAGE-DEPENDENT REGULA - TION OF THE CA V 2.1 CHANNEL. Kaiqian Wang , Antonios Pantazis 122-Plat 12:30 pm CRYSTALLOGRAPHIC INSIGHTS INTO CARDIOMYOPATHY MUTATIONS AND VOLTAGE-GATED CALCIUM CHANNEL TARGETING BY JUNCTOPHILINS. Zheng Fang Yang , Pankaj Panwar, Ciaran McFarlane, Marta Campiglio, Wietske E. Tuinte, Filip Van Petegem Platform Membrane Pumps, Transporters, and Exchangers 10:45 am - 12:45 pm, South, Level Two, Room 215/216 Co-Chairs Pablo Artigas, Texas Tech University Health Sciences Center, USA Ekaterina D. Kots, Cornell University, USA 123-Plat 10:45 am VISUALIZING THE BINDING MODE OF THE ANTIDEPRESSANT VILAZODO - NE ON THE SEROTONIN TRANSPORTER BY CRYO-EM. Iris E. Kalenderoglou , Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, amy H. Newman, Eric Gouaux, Jonathan A. Coleman, Claus J. Loland 124-Plat 11:00 am VOLTAGE DEPENDENCE OF MONOAMINE TRANSPORTER FUNCTION IS DETERMINED BY HANDLING OF INTRACELLULAR POTASSIUM. Shreyas Bhat , Marco Niello, Klaus Schicker, Christian Pifl, Harald Sitte, Michael Freissmuth, Walter Sandtner 125-Plat 11:15 am TONIC INHIBITION OF THE CHLORIDE/PROTON ANTIPORTER CLC-7 BY PI(3,5)P2 IS CRUCIAL FOR LYSOSOMAL PH MAINTENANCE. Jacob K. Hilton , Xavier Leray, Kamsiyochukwu Nwangwu, Alissa J. Becerril, Gabriel Fitzgerald, Anowarul amin, Mary Weston, Joseph A. Mindell 126-Plat 11:30 am ACCESSING INTRACELLULAR MEMBRANE TRANSPORT PROTEINS - A NOVEL ELECTROPHYSIOLOGICAL APPROACH FOR LYSOSOMAL AND MITOCHONDRIAL CHANNELS AND TRANSPORTERS. Maria Barthmes , Andre Bazzone, Rocco Zerlotti, Cecilia George, Michael George, Andrea Bruggemann, Niels Fertig 127-Plat 11:45 am INTERMEDIATES, STATE TRANSITIONS, AND LIGAND COUPLING IN THE DYNAMIC MECHANISM OF THE HEAAT3 GLUTAMATE TRANSPORTER. Ekaterina D. Kots , Harel Weinstein 128-Plat 12:00 pm Travel Award Winner ROLE OF A CONSERVED ION-BINDING SITE TYROSINE IN ION SELECTIVITY OF THE NA/K PUMP. Kerri Spontarelli , Daniel T. Infield, Hang N. Nielsen, Rikke H. Jensen, Victoria C. Young, Jason D. Galpin, Christopher A. Ahern, Bente Vilsen, Pablo Artigas L. Minor 120-Plat 12:00 pm

F R I D A Y

S U N D A Y

20