Biophysical Society 66th Annual Meeting Program Guide

Exhibitor Presentation Dynamic Biosensors 3:30 pm - 5:00 pm, Esplanade, Room 157 Measurement of PROTAC Ternary Complex Formation Using the switchSENSE® Y-Structure and FRET Signals Proteolysis targeting chimeras (PROTACs) are essential bifunctional small molecules that engage the formation of a ternary complex consisting of an E3 ubiquitin ligase, a target protein of interest and the PROTAC itself. Using switchSENSE® technology and the novel DNA Y-structure, an E3 ligase as well as a target protein can be functionalized on each separate end of two FRET pair color-coded Y-arms. The Y-structure closes upon PROTAC binding and the subsequent ternary complex formation bringing together the green donor and the red acceptor dye into a closer, FRET sensitive, distance. The change in red fluorescence signal intensity directly correlates with ternary complex formation kinetics. Here, we show that the Y-structure is an extremely versatile tool for studying any type of protein-protein complex formations with a dis- sociation constant between 1nM to 10µM. With the switchSENSE® technology and the highly sensitive FRET read-out, it is possible to perform high-throughput PROTAC screening and to characterize their kinetics (PROTACs ranking), gaining information on binary and ternary binding at the same time. Speaker Jonathan Faherty, Head of Operations, Dynamic Biosensors Career Development Center Workshop Nailing the Job Talk, or Erudition Ain’t Enough 4:00 pm - 5:00 pm, Esplanade, Room 151 Congratulations! You've made it to the finals and are suddenly facing the most important presentation of your life. Attend this session for an- swers to your questions about how to structure your presentation, how much detail to include, and what they are really looking for, etc. Biophysical Journal Associate Editors Meeting 4:00 pm - 6:00 pm, South, Level Three, Room 311 Symposium Imaging and Modeling of the Brain 4:00 pm - 6:00 pm, South, Level Three, Room 301/302 Chair Orly Reiner, Weizmann Institute of Science, Israel 131-Symp 4:00 pm MODELING BRAIN MORPHOGENESIS BY INTEGRATING GROWTH BE- HAVIOR ON CELL AND TISSUE SCALES. Christopher D. Kroenke , Kara E. Garcia, Philip V. Bayly, Xiaojie Wang, Sarah E. Santiago 132-Symp 4:30 pm BRAIN EXTRACELLULAR SPACE CHANGES DYNAMICALLY DURING PHYSI- OLOGICAL AND PATHOLOGICAL NEURONAL ACTIVITY. Sabina Hrabetova 133-Symp 5:00 pm MULTI-SCALE PERSONALIZED BRAIN MODELING. Petra Ritter 134-Symp 5:30 pm LIS1, AN RNA-BINDING PROTEIN, REGULATES THE PHYSICAL PROPERTIES OF EMBRYONIC STEM CELLS. Orly Reiner , Aditya Kshirsagar

Snack Break 1:45 pm - 3:00 pm, Exhibit Hall ABC Poster Presentations and Late Posters 1:45 pm - 3:45 pm, Exhibit Hall ABC Teaching Science Like We Do Science 2:00 pm - 4:00 pm, Esplanade, Room 155

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This interactive, hands-on workshop focuses on practice-applicable, easy-to-use strategies and tools that educators at any level of biophysical science education can use to assess what their students take away from their teaching, and where changes to their educational methods might be appropriate. Speakers Career Development Center Workshop Focus on Teaching: Building Your Career as a Teacher 2:30 pm - 3:30 pm, Esplanade, Room 151 In this session we will address the elements needed to become a success- ful and engaging teacher and to build a career involving teaching. We will discuss skill development, opportunity and resource identification and allocation, how to recruit students for your lab/group, and how to build a strong mentoring program. We will also delve into how to identify grant and other funding opportunities as well as additional training opportuni- ties to be a skilled teacher. Exhibitor Presentation Delmic 2:30 pm - 4:00 pm, Esplanade, Room 158 People or Projects? Approaches to Funding Research 2:30 pm - 4:00 pm, Esplanade, Room 154 As scientific research continues to grow and advance with new, ground- breaking techniques, tools and mechanisms, we are also seeing a new evolution in how this research is funded. Through need and necessity, the United Kingdommust reinvest in itself to carve out funding for research, over the past fifteen years France has moved to grant-based funding for scientific research. Meanwhile, both the United States, through its proposed creation of the Advanced Research Projects Agency for Health (ARPA-H), and the Burroughs Wellcome Fund, through the Leap initiative, are pushing toward high-risk, high-reward biomedical research. This ses- sion will explore how we, as scientists, navigate the line between funding people verses funding projects. Speakers Gundula Bosch, Johns Hopkins University Yadilette Rivera-Colón, Baypath University

Theresa Good, NSF Tara Schwetz, NIH Kaigham “Ken” Gabriel, Wellcome Leap

Early Careers Committee Meeting 3:30 pm - 5:00 pm, South, Level Three, Room 312

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