Biophysical Society 66th Annual Meeting Program Guide

Symposium AAA+ Machine 4:00 pm - 6:00 pm, South, Level Three, Room 303/304 Chair Christopher Hill, University of Utah, USA 135-Symp 4:00 pm TIME COURSE ANALYSIS PROVIDES INFORMATION ON INTRACELLULAR RETROGRADE TRANSPORT BY DYNEIN. Kumiko Hayashi 136-Symp 4:30 pm TO CUT OR NOT TO CUT: A VIEW INTO MICROTUBULE SEVERING MA- CHINES. Ruxandra Dima No Abstract 5:00 pm CONTROLLING SPECIFICITY OF AAA+ PROTEASES DURING REGULATED PROTEOLYSIS. Peter Chien No Abstract 5:30 pm STRUCTURAL INSIGHTS TO THE MECHANISM OF AAA UNFOLDASES. Christopher Hill Platform Structural Virology 4:00 pm - 6:00 pm, South, Level Two, Room 201/202/203 Co-Chairs Kelly Lee, University of Washington, USA Magnus Bauer, Stanford University, USA 137-Plat 4:00 pm A CRYPTIC POCKET IN EBOLA VP35 ALLOSTERICALLY CONTROLS RNA BINDING. Matthew A. Cruz 138-Plat 4:15 pm Travel Award Winner ARCHITECTURE AND ANTIGENICITY OF THE NIPAH VIRUS ATTACHMENT GLYCOPROTEIN. Zhaoqian Wang 139-Plat 4:30 pm THE SARS-COV-2 SPIKE PROTEIN REVERSIBLY SAMPLES AN OPEN-TRIMER CONFORMATION EXPOSING NOVEL EPITOPES. Sophie R. Shoemaker , Shawn M. Costello, Helen T. Hobbs, Annalee W. Nguyen, Ching-Lin Hsieh, Jennifer A. Maynard, Jason S. McLellan, John E. Pak, Susan Marqusee 140 -Plat 4:45 pm A TETHERED LIGAND ASSAY TO PROBE SARS-COV-2:ACE2 INTERACTIONS. Magnus S. Bauer , Sophia Gruber, Adina Hausch, Lukas F. Milles, Thomas Nicolaus, Leonard C. Schendel, Pilar López Navajas, Erik Procko, Daniel Lietha, Rafael C. Bernardi, Jan Lipfert, Hermann E. Gaub 141 -Plat 5:00 pm STRUCTURAL BASIS OF THE ENTROPY OF MULTIVALENT BINDING IN ANTIBODIES. Nathalie Wyss 142-Plat 5:15 pm PROBING STRUCTURAL DYNAMICS BY MASS SPECTROMETRY PROVIDES NEW INSIGHTS INTO HIV'S STRUCTURAL AND ANTIGENIC DIVERSITY. Edgar A. Hodge , Sally Kephart, Wenjin Guo, Shiu-Lok Hu, John P. Moore, Rogier W. Sanders, Kelly K. Lee 143-Plat 5:30 pm CRYO-EM STRUCTURES OF NOVEL ARENVIRAL FUSION GLYCOPROTEINS REVEAL CONSERVED SITES OF VULNERABILITY. Hailee R. Perrett , Philip J.M. Brouwer, Aleksandar Antanasijevic, Neil P. King, Rogier W. Sanders, Andrew B. Ward

144 -Plat 5:45 pm STRUCTURE FUNCTION CHARACTERIZATION OF SARS COV2 PROTEASES FOR COVID19 ANTIVIRAL DEVELO pm ENT. Rebecca Greene-Cramer , Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa Ramelot, Thomas B. Acton, Elena Moreno Del Olmo, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo Garcia-Sastre, Robert Krug, Gaetano T. Montelione Platform Computational Methods and Bioinformatics I 4:00 pm - 6:00 pm, South, Level Two, Room 204/205/206 Co-Chairs Erik Lindahl, Stockholm University, Sweden Ziwei He, University of Chicago, USA 145-Plat 4:00 pm PROTEIN STRUCTURAL ENSEMBLES BY INTEGRATIVE COMPUTATIONAL- EXPERIMENTAL APPROACHES. Massimiliano Bonomi 146-Plat 4:15 pm GENTLE ALL-ATOMMD REFINEMENT TO CRYO-EM DENSITIES VIA BAYES' APPROACH. Christian Blau, Linnea Yvonnesdotter, Erik Lindahl 147-Plat 4:30 pm INTEGRATION OF SOFTWARE TOOLS FOR INTEGRATIVE MODELING OF BIOMOLECULAR SYSTEMS. Matthew Hancock , Thomas-Otavio Peulen, Benjamin Webb, James S. Fraser, Paul D. Adams, Andrej Sali 148-Plat 4:45 pm RIGID-BODY ASSIGNMENT IN INTEGRATIVE DETERMINATION OF PRO- TEIN COMPLEX STRUCTURES. Tanmoy Sanyal , Andrej Sali 149-Plat 5:00 pm DESIGN PRINCIPLES OF MARKOV STATE MODELS AND VARIATIONAL STRING METHOD FOR PROTEIN-PROTEIN INTERACTIONS. Ziwei He , Fabian Paul, Benoit Roux 150-Plat 5:15 pm MACHINE LEARNING REVEALS THE CRITICAL INTERACTIONS FOR SARS- COV-2 SPIKE PROTEIN BINDING TO ACE2. Anna Pavlova, Zijian Zhang , Atanu Acharya, Diane L. Lynch, Yui Tik Pang, Zhongyu Mou, Jerry M. Parks, Christophe J. Chipot, James C. Gumbart 151-Plat 5:30 pm SIMULTANEOUS MULTICOLOR IMAGING AND MULTISCALE ANALYSIS OF RECEPTOR ORGANIZATION AND ACTIN CORTEX DYNAMICS. Huong-Tra Ngo , Aparajita Dasgupta, Deryl Tschoerner, Nicolas Touret, Bruno da Rocha-Azevedo, Khuloud Jaqaman 152-Plat 5:45 pm ACCURATE SEGMENTATION AND TRACKING OF SINGLE CELLS IN COM- PLEX 4D BACTERIAL BIOFILMS USING MACHINE LEARNING. Yibo Wang , Ji Zhang, Eric D. Donarski, Andreas Gahlmann Platform Transcription and Translation 4:00 pm - 6:00 pm, South, Level Two, Room 207/208 Co-Chairs Heejun Choi, Janelia Res Campus, HHMI, USA Jinfan Wang, Stanford University, USA 153-Plat 4:00 pm STRUCTURAL BASIS OF EARLY TRANSLOCATION EVENTS ON THE RIBO- SOME. Emily J. Rundlet , Mikael Holm, Magdalena Schacherl, Kundhavai Natchiar, Roger B. Altman, Christian M.T. Spahn, Alexander G. Myasnikov, Scott C. Blanchard

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